TT genotype vs TG+GG genotypes: Dental caries
- Population
- Children (<18 years) with vs without dental caries
- Intervention
- TT genotype
- Comparison
- TG+GG genotypes
- Outcome
- Dental caries
TaqI/BglI(rs739837) recessive model: TT vs TG+GG was not significantly associated with dental caries (OR 0.93); ungraded.
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
TT genotype vs TG+GG genotypes Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TG+GG), Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India) TaqI/BglI(rs739837) recessive model: TT vs TG+GG was not significantly associated with dental caries (OR 0.93); ungraded. Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) All outcomes | OR 0.93 [0.68, 1.29] | 3 studies · 796 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and meta-analysis. 2024 All outcomes | 31 August 2022 | 10 | Not applicable |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- TT genotype vs TC+CC genotypes · Children (<18 years) with vs without dental caries · 1 review
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Evaluation of vitamin D receptor genetic polymorphisms with dental caries and developmental defects of enamel in Brazilian children · 2020 · included by 1 of these review
- The relationship between molar incisor hypomineralization, dental caries, socioeconomic factors, and polymorphisms in the vitamin D… · 2020 · included by 1 of these review
- Vitamin D receptor FokI and BglI genetic polymorphisms, dental caries, and gingivitis. · 2020 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.