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Evidence found and GRADE certainty

394 questions · 795 findings · 66 reviews · Dental caries

No studies found 5 · 0.6%GRADE not reported 753 · 94.7%Very low 31 · 3.9%Low 4 · 0.5%Moderate 2 · 0.3%High 0 · 0%

Primary teeth / primary dentition (younger children) vs Permanent teeth / permanent dentition (older children)

Dental caries susceptibility · Institutionalized orphan children (roughly 3 to 18 years)

Primary teeth may carry a higher caries risk than permanent teeth in institutionalized children (RR 1.31), but the difference is not statistically significant (very low certainty).

1 finding from 1 review

Nocturnal breastfeeding vs No nocturnal breastfeeding

Early childhood caries (ECC) · Preschool children (<6 years)

After excluding one study, nocturnal breastfeeding was associated with higher ECC risk (RR 3.05, 95% CI 2.40 to 3.87; I²=33%).

2 findings from 1 review

Breastfeeding <24 months vs Breastfeeding for ≥24 months

Early childhood caries (ECC) · Preschool children (<6 years)

After excluding Peres et al. (2017), breastfeeding for less than 24 months was associated with fewer caries (RR 0.49, 95% CI 0.39 to 0.62; I²=6%).

2 findings from 1 review

Breastfeeding vs No breastfeeding

Early childhood caries (ECC) · Preschool children (<6 years)

After excluding five studies, breastfeeding was associated with lower ECC risk in cohort studies (RR 0.82, 95% CI 0.71 to 0.95; I²=0%).

3 findings from 1 review

Breastfeeding <12 months vs Breastfeeding for ≥12 months

Early childhood caries (ECC) · Preschool children (<6 years)

Breastfeeding for <12 vs ≥12 months was associated with significantly fewer caries (RR 0.65, 95% CI 0.50-0.86), indicating breastfeeding beyond 12 months increases ECC risk (substantial heterogeneity; ungraded).

2 findings from 1 review

Breastfeeding <18 months vs Breastfeeding for ≥18 months

Early childhood caries (ECC) · Preschool children (<6 years)

Breastfeeding for <18 vs ≥18 months was associated with significantly fewer caries (RR 0.41, 95% CI 0.18-0.92; substantial heterogeneity; ungraded).

2 findings from 1 review

Strategies to integrate oral health into primary care (e.g., training/education of non-dental primary care professionals, policy/financing and health-insurance changes, colocation of dental and medical services, interprofessional and community-health-worker collaboration, teledentistry, integrated oral health assessment tools, school-based activities)

Dental caries estimates · People receiving or providing primary care; all ages, ability types, and locations

Seven studies measured change in dental caries estimates.

1 finding from 1 review

Maternal smoking during pregnancy vs No maternal smoking during pregnancy

Dental caries in children · Children in cross-sectional studies

The cross-sectional association remained statistically significant after excluding Julihn et al. 2018.

7 findings from 1 review
Show 4 more findings

Initiation of water fluoridation (artificial or natural) vs Low/non-fluoridated water (0.4 ppm fluoride or less)

Dental caries in adults · adults

The review found no eligible studies for this question.

1 finding from 1 review
  • Water fluoridation for the prevention of dental caries 2015 · Cochrane All outcomes
    Adults
    No studies that aimed to determine the effectiveness of water fluoridation for preventing caries in adults met the review's inclusion criteria. There are no data to determine the effect of water fluoridation on caries…
    0 studies
    No studies found

Iron deficiency anemia (IDA) vs Children without anemia (non-anemic)

Dental caries · Children or adolescents

Children with iron deficiency anemia are over three times more likely to have dental caries than non-anemic children (OR 3.64, 95% CI 2.45 to 5.40; moderate certainty).

1 finding from 1 review

Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries prevalence · Children aged 2 to 8 years

The review reported 44% dental caries prevalence among children of mothers with low prenatal vitamin D.

2 findings from 1 review

Slum / urban-disadvantaged setting vs Non-slum urban / general-urban / national population

Dental caries prevalence · Adult residents of slums and non-slum urban settings of LMICs

Dental caries prevalence in LMIC urban/slum populations ranges widely (13%-76%); not GRADE-rated (narrative synthesis).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Caries experience · Children and adolescents (<18 years) living with HIV (CLWH)

ART was not associated with a significant difference in dental caries experience among CLWH (very low certainty).

1 finding from 1 review

Presence of dental plaque vs Absence of dental plaque

Dental caries · Individuals in Ethiopia assessed for dental caries

The presence of dental plaque was not significantly associated with dental caries (OR 5.14, 95% CI 0.67 to 39.39); certainty not graded.

1 finding from 1 review

Private day care vs Public day care

Dental caries prevalence · Preschool children in Sharjah day cares

Caries prevalence was 77% in private day cares versus 22% in public day cares.

2 findings from 1 review