Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

424 questions · 424 findings · 136 reviews

No studies found 93 · 21.9%GRADE not reported 14 · 3.3%Very low 130 · 30.7%Low 114 · 26.9%Moderate 58 · 13.7%High 15 · 3.5%

Fluoroquinolones vs beta‐lactams

Discontinuation of medication due to adverse events · patients with Shigella dysentery

It is very uncertain whether fluoroquinolones changes adverse events leading to discontinuation of treatment compared with beta‐lactams (very low certainty).

1 finding from 1 review

Group A: amino acids vs placebo

Adverse effects: suicidal thoughts (events) · people in the prodromal stage of psychosis

It is very uncertain whether group A: amino acids changes adverse effects: suicidal thoughts Short‐term (events) compared with placebo (very low certainty).

1 finding from 1 review

Acupuncture vs sham

Number of minor adverse events · Adults with overactive bladder (OAB)

Acupuncture showed no clear difference in number of minor adverse events compared with sham acupuncture (moderate certainty).

1 finding from 1 review

Anticoagulant vs different dose of the same anticoagulant

Adverse events (minor bleeding) · non‐hospitalised individuals with COVID‐19 (asymptomatic and mild disease)

Anticoagulant showed no clear difference in adverse events (minor bleeding) compared with different dose of the same anticoagulant (low certainty).

1 finding from 1 review

Probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine) vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Withdrawals due to adverse events · Patients with quiescent ulcerative colitis

It is very uncertain whether probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine) changes withdrawal due to adverse events (12 to 52 weeks) compared with 5‐ASA (mesalazine) (very low certainty).

1 finding from 1 review