Cochrane · systematic review · CD012059
Desmopressin for treating nocturia in men
Han, J, Jung, JH, Bakker, CJ, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
UrologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
42
current version
GRADE rated
26
No studies
16
Included studies
NR
No studies 16 · 38.1%Ungraded 0 · 0%Very low 4 · 9.5%Low 16 · 38.1%Moderate 6 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Desmopressin versus placebo for men with nocturia (short term)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of nocturnal voids Desmopressin vs placebo | no estimate extracted | 6 studies · 1982 participants | Low Downgraded: risk of bias, inconsistency |
Quality of life ‐ not reported Desmopressin vs placebo | no estimate extracted | NR | No studies |
Major adverse events Desmopressin vs placebo | RR 0.97 [0.1, 9.03] | 2 studies · 536 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Duration of first sleep episode Desmopressin vs placebo | no estimate extracted | 4 studies · 652 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Time to first void Desmopressin vs placebo | no estimate extracted | 1 study · 383 participants | Low Downgraded: risk of bias, imprecision |
Minor adverse event Desmopressin vs placebo | RR 0.87 [0.67, 1.13] | 3 studies · 594 participants | Low Downgraded: risk of bias, imprecision |
Treatment withdrawal due to adverse event Desmopressin vs placebo | RR 1.1 [0.56, 2.15] | 4 studies · 614 participants | Low Downgraded: risk of bias, imprecision |
Desmopressin versus placebo for men with nocturia (intermediate term)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of nocturnal voids Desmopressin vs placebo | no estimate extracted | 1 study · 115 participants | Low Downgraded: risk of bias, imprecision |
Quality of life ‐ not reported Desmopressin vs placebo | no estimate extracted | NR | No studies |
Major adverse events Desmopressin vs placebo | RR 3.05 [0.13, 73.39] | 1 study · 115 participants | Low Downgraded: risk of bias, imprecision |
Duration of first sleep episode Desmopressin vs placebo | no estimate extracted | 1 study · 115 participants | Moderate Downgraded: risk of bias |
Time to first void ‐ not reported Desmopressin vs placebo | no estimate extracted | NR | No studies |
Minor adverse events Desmopressin vs placebo | RR 0.86 [0.49, 1.49] | 1 study · 115 participants | Low Downgraded: risk of bias, imprecision |
Treatment withdrawal due to adverse event Desmopressin vs placebo | RR 3.05 [0.13, 73.39] | 1 study · 115 participants | Low Downgraded: risk of bias, imprecision |
Desmopressin versus behaviour modifications for men with nocturia (short term)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of nocturnal voids ‐ not reported Desmopressin vs behaviour modifications | no estimate extracted | NR | No studies |
Quality of life ‐ not reported Desmopressin vs behaviour modifications | no estimate extracted | NR | No studies |
Major adverse events ‐ not reported Desmopressin vs behaviour modifications | no estimate extracted | NR | No studies |
Duration of first sleep episode Desmopressin vs behaviour modifications | no estimate extracted | 1 study · 60 participants | Low Downgraded: risk of bias, imprecision |
Time to first void ‐ not reported Desmopressin vs behaviour modifications | no estimate extracted | NR | No studies |
Minor adverse events ‐ not reported Desmopressin vs behaviour modifications | no estimate extracted | NR | No studies |
Treatment withdrawal due to adverse event ‐ not reported Desmopressin vs behaviour modifications | no estimate extracted | NR | No studies |
Desmopressin versus alpha‐blocker for men with nocturia (short term)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of nocturnal voids Desmopressin vs alpha‐blocker | no estimate extracted | 1 study · 31 participants | Moderate Downgraded: risk of bias |
Quality of life Desmopressin vs alpha‐blocker | no estimate extracted | 1 study · 31 participants | Moderate Downgraded: risk of bias |
Major adverse events Desmopressin vs alpha‐blocker | no estimate extracted | 1 study · 31 participants | Low Downgraded: risk of bias, imprecision |
Duration of first sleep episode ‐ not reported Desmopressin vs alpha‐blocker | no estimate extracted | NR | No studies |
Time to first void ‐ not reported Desmopressin vs alpha‐blocker | no estimate extracted | NR | No studies |
Minor adverse events Desmopressin vs alpha‐blocker | RR 1.07 [0.07, 15.57] | 1 study · 31 participants | Very low Downgraded: risk of bias, imprecision |
Treatment withdrawal due to adverse event Desmopressin vs alpha‐blocker | no estimate extracted | 1 study · 31 participants | Low Downgraded: risk of bias, imprecision |
Desmopressin plus alpha‐blocker versus alpha‐blocker for men with nocturia (short term)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of nocturnal voids Desmopressin plus alpha‐blocker vs alpha‐blocker | no estimate extracted | 3 studies · 341 participants | Moderate Downgraded: risk of bias |
Quality of life Desmopressin plus alpha‐blocker vs alpha‐blocker | no estimate extracted | 3 studies · 341 participants | Moderate Downgraded: risk of bias |
Major adverse events Desmopressin plus alpha‐blocker vs alpha‐blocker | RR 0.3 [0.01, 7.32] | 3 studies · 402 participants | Low Downgraded: risk of bias, imprecision |
Duration of first sleep episode ‐ not reported Desmopressin plus alpha‐blocker vs alpha‐blocker | no estimate extracted | NR | No studies |
Time to first void ‐ not reported Desmopressin plus alpha‐blocker vs alpha‐blocker | no estimate extracted | NR | No studies |
Minor adverse events Desmopressin plus alpha‐blocker vs alpha‐blocker | RR 1.6 [0.15, 16.82] | 3 studies · 402 participants | Very low Downgraded: risk of bias, imprecision |
Treatment withdrawal due to adverse event Desmopressin plus alpha‐blocker vs alpha‐blocker | RR 2.84 [0.46, 17.66] | 3 studies · 402 participants | Low Downgraded: risk of bias, imprecision |
Desmopressin plus alpha‐blocker versus alpha‐blocker plus anticholinergic for men with nocturia (short term)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of nocturnal voids Desmopressin plus alpha‐blocker vs alpha‐blocker plus anticholinergic | no estimate extracted | 1 study · 405 participants | Moderate Downgraded: risk of bias |
Quality of life ‐ not reported Desmopressin plus alpha‐blocker vs alpha‐blocker plus anticholinergic | no estimate extracted | NR | No studies |
Major adverse events Desmopressin plus alpha‐blocker vs alpha‐blocker plus anticholinergic | no estimate extracted | 1 study · 427 participants | Low Downgraded: risk of bias, imprecision |
Duration of first sleep episode ‐ not reported Desmopressin plus alpha‐blocker vs alpha‐blocker plus anticholinergic | no estimate extracted | NR | No studies |
Time to first void ‐ not reported Desmopressin plus alpha‐blocker vs alpha‐blocker plus anticholinergic | no estimate extracted | NR | No studies |
Minor adverse events Desmopressin plus alpha‐blocker vs alpha‐blocker plus anticholinergic | RR 0.22 [0.05, 0.98] | 1 study · 427 participants | Low Downgraded: risk of bias, imprecision |
Treatment withdrawal due to adverse event Desmopressin plus alpha‐blocker vs alpha‐blocker plus anticholinergic | RR 0.22 [0.05, 0.98] | 1 study · 427 participants | Low Downgraded: risk of bias, imprecision |