Question · asked by 1 review

Oral ciclosporin vs azathioprine (AZA): Adverse events: minor (hirsutism)

Population
patients with cutaneous disease in systemic lupus erythematosus
Intervention
Oral ciclosporin
Comparison
azathioprine (AZA)
Outcome
Adverse events: minor (hirsutism)

Oral ciclosporin may leads to higher adverse events: minor (hirsutism) compared with oral azathioprine (low certainty).

What each review found

Include earlier review versions
FindingEffectStudiesGRADE certainty
Oral ciclosporin vs oral azathioprine
Adverse events: minor (hirsutism) · patients with cutaneous disease in systemic lupus erythematosus
Oral ciclosporin may leads to higher adverse events: minor (hirsutism) compared with oral azathioprine (low certainty).
Interventions for cutaneous disease in systemic lupus erythematosus (2021) · Cochrane Headline outcomes only
RR 9.83 [1.32, 72.95]1 study · 89 participantsLow

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Interventions for cutaneous disease in systemic lupus erythematosus
2021 · Cochrane Headline outcomes only
Not reportedNot extractedNot assessed
How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.