Probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine) vs 5‐aminosalicylic acid (5‐ASA) (mesalazine): Withdrawals due to adverse events
- Population
- Patients with quiescent ulcerative colitis
- Intervention
- Probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine)
- Comparison
- 5‐aminosalicylic acid (5‐ASA) (mesalazine)
- Outcome
- Withdrawals due to adverse events
It is very uncertain whether probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine) changes withdrawal due to adverse events (12 to 52 weeks) compared with 5‐ASA (mesalazine) (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine) vs 5‐ASA (mesalazine) Withdrawal due to adverse events (12 to 52 weeks) · people with ulcerative colitis in remission It is very uncertain whether probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine) changes withdrawal due to adverse events (12 to 52 weeks) compared with 5‐ASA (mesalazine) (very low certainty). Probiotics for maintenance of remission in ulcerative colitis (2020) · Cochrane Headline outcomes only | RR 5.29 [0.26, 107.63] | 2 studies · 127 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Probiotics for maintenance of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine) vs 5‐aminosalicylic acid (5‐ASA) (mesalazine) · people with active UC · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.