Cochrane · systematic review · CD012071
Antibiotic treatment for newborns with congenital syphilis
Walker, GJA, Walker, D, Molano Franco, D, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Sexually Transmitted InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
5
No studies
5
Included studies
NR
No studies 5 · 45.5%Ungraded 1 · 9.1%Very low 0 · 0%Low 3 · 27.3%Moderate 1 · 9.1%High 1 · 9.1%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antibiotic treatment compared to no intervention for newborns with congenital syphilis
Population: newborns with congenital syphilis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Neonatal death rate due congenital syphilis Antibiotic treatment vs no intervention | no estimate extracted | NR | No studies |
Neonatal death rate due any cause Antibiotic treatment vs no intervention | RR 0.83 [0.06, 11.7] | 1 study · 22 participants | Low |
Absence of clinical manifestations of congenital syphilis during Antibiotic treatment vs no intervention | RR 0.12 [0.01, 2.09] | 1 study · 22 participants | Low |
Serious adverse events Antibiotic treatment vs no intervention | no estimate extracted | NR | No studies |
Serological cure (≥ 4‐fold decrease in non‐treponemal tests titre) Antibiotic treatment vs no intervention | RR 2.13 [1.06, 4.27] | 1 study · 20 participants | Low |
Minor adverse events of therapy Antibiotic treatment vs no intervention | no estimate extracted | NR | No studies |
Antibiotic treatment (benzathine penicillin) compared to any other antibiotic (procaine benzylpenicillin) for newborns with congenital syphilis
Population: newborns with congenital syphilis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Neonatal death rate due congenital syphilis Antibiotic treatment (benzathine penicillin) vs any other antibiotic (procaine benzylpenicillin) | no estimate extracted | 0 participants | Ungraded |
Neonatal death rate due to any cause Antibiotic treatment (benzathine penicillin) vs any other antibiotic (procaine benzylpenicillin) | no estimate extracted | NR | No studies |
Absence of clinical manifestations of congenital syphilis during Antibiotic treatment (benzathine penicillin) vs any other antibiotic (procaine benzylpenicillin) | RR 1 [0.97, 1.03] | 1 study · 152 participants | High |
Serological cure (4‐fold decrease or greater in non‐treponemal tests titre) Antibiotic treatment (benzathine penicillin) vs any other antibiotic (procaine benzylpenicillin) | RR 1 [0.97, 1.03] | 1 study · 129 participants | Moderate Downgraded: risk of bias |
Minor adverse events of therapy Antibiotic treatment (benzathine penicillin) vs any other antibiotic (procaine benzylpenicillin) | no estimate extracted | NR | No studies |