Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

303 questions in 64 reviews · Hepato-Biliary

current versions
No studies 303 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Summary of findings table ‐ Antibiotics vs placebo or no intervention
Serious adverse event ‐ not reported · people with leptospirosis
Antibiotics for treatment of leptospirosis (2024) · Cochrane
no estimate extractedNRNo studies
Prostaglandin vs placebo or standard care
Health‐related quality of life · adult liver transplanted recipients
Prostaglandins for adult liver transplanted recipients (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Outcomes  · adults with compensated or decompensated advanced chronic liver disease
Granulocyte colony‐stimulating factor with or without stem or progenitor cell or growth factors infusion for… (2023) · Cochrane
no estimate extractedNRNo studies
Normothermic machine perfusion (NMP) vs static cold storage (SCS)
Quality of life ‐ not measured · liver transplant recipients
Machine perfusion in liver transplantation (2023) · Cochrane
no estimate extractedNRNo studies
Hypothermic oxygenated perfusion (HOPE) vs static cold storage (SCS)
Quality of life ‐ not measured · liver transplant recipients
Machine perfusion in liver transplantation (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Intraperitoneal local anaesthetic vs control
Health related quality of life ‐ not measured · patients undergoing laparoscopic cholecystectomy
Intraperitoneal local anaesthetic instillation versus no intraperitoneal local anaesthetic instillation for… (2021) · Cochrane
no estimate extractedNRNo studies
Summary of Findings Table ‐ Electrocoagulation in combination with allopurinol or with dimethyl sulphoxide vs control (vehicle solution of allopurinol by mouth)
Tumour response · people with liver metastases
Electrocoagulation for liver metastases (2021) · Cochrane
no estimate extractedNRNo studies
Summary of Findings Table ‐ Electrocoagulation alone vs control (vehicle solution of allopurinol by mouth)
Other adverse events and complications · people with liver metastases
Electrocoagulation for liver metastases (2021) · Cochrane
no estimate extractedNRNo studies
Summary of Findings Table ‐ Electrocoagulation alone vs control (vehicle solution of allopurinol by mouth)
Failure to clear liver metastases or recurrence of liver metastases · people with liver metastases
Electrocoagulation for liver metastases (2021) · Cochrane
no estimate extractedNRNo studies
Summary of Findings Table ‐ Electrocoagulation alone vs control (vehicle solution of allopurinol by mouth)
Tumour response · people with liver metastases
Electrocoagulation for liver metastases (2021) · Cochrane
no estimate extractedNRNo studies
Summary of Findings Table ‐ Electrocoagulation in combination with allopurinol or with dimethyl sulphoxide vs control (vehicle solution of allopurinol by mouth)
Other adverse events and complications · people with liver metastases
Electrocoagulation for liver metastases (2021) · Cochrane
no estimate extractedNRNo studies
Summary of Findings Table ‐ Electrocoagulation in combination with allopurinol or with dimethyl sulphoxide vs control (vehicle solution of allopurinol by mouth)
Failure to clear liver metastases or recurrence of liver metastases · people with liver metastases
Electrocoagulation for liver metastases (2021) · Cochrane
no estimate extractedNRNo studies
Band ligation vs sham or no intervention
Health‐related quality of life · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or…
Band ligation versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in… (2021) · Cochrane
no estimate extractedNRNo studies
Band ligation vs sham or no intervention
Adverse events considered not serious · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or…
Band ligation versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in… (2021) · Cochrane
no estimate extractedNRNo studies
Adjuvant chemotherapy vs no chemotherapy
Health‐related quality of life · people with resectable cholangiocarcinoma
Postoperative adjuvant chemotherapy for resectable cholangiocarcinoma (2021) · Cochrane
no estimate extractedNRNo studies
Adjuvant chemotherapy vs no chemotherapy
Cancer‐related mortality · people with resectable cholangiocarcinoma
Postoperative adjuvant chemotherapy for resectable cholangiocarcinoma (2021) · Cochrane
no estimate extractedNRNo studies
Adjuvant chemotherapy vs no chemotherapy
TIme to recurrence of the tumour · people with resectable cholangiocarcinoma
Postoperative adjuvant chemotherapy for resectable cholangiocarcinoma (2021) · Cochrane
no estimate extractedNRNo studies
Adjuvant chemotherapy vs no chemotherapy
Non‐serious adverse events · people with resectable cholangiocarcinoma
Postoperative adjuvant chemotherapy for resectable cholangiocarcinoma (2021) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Interventions · people with liver cirrhosis and oesophageal varices with no history of bleeding
Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… (2021) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Beta‐blockers · people with liver cirrhosis and oesophageal varices with no history of bleeding
Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… (2021) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Interventions · people with liver cirrhosis and previous oesophageal variceal bleeding
Secondary prevention of variceal bleeding in adults with previous oesophageal variceal bleeding due to… (2021) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Sclerotherapy · people with liver cirrhosis and previous oesophageal variceal bleeding
Secondary prevention of variceal bleeding in adults with previous oesophageal variceal bleeding due to… (2021) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Interventions · people with nonalcohol‐related fatty liver disease (NAFLD)
Lifestyle modifications for nonalcohol‐related fatty liver disease: a network meta‐analysis (2021) · Cochrane
no estimate extractedNRNo studies
Intervention NR
No active intervention · people with nonalcohol‐related fatty liver disease (NAFLD)
Lifestyle modifications for nonalcohol‐related fatty liver disease: a network meta‐analysis (2021) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Interventions · people with non‐alcohol‐related fatty liver disease (NAFLD)
Nutritional supplementation for nonalcohol‐related fatty liver disease: a network meta‐analysis (2021) · Cochrane
no estimate extractedNRNo studies
Intervention NR
No active intervention · people with non‐alcohol‐related fatty liver disease (NAFLD)
Nutritional supplementation for nonalcohol‐related fatty liver disease: a network meta‐analysis (2021) · Cochrane
no estimate extractedNRNo studies
Distal splenorenal shunt vs endoscopic intervention
Health‐related quality of life · participants with cirrhosis and with previous oesophagogastric variceal bleeding
Portosystemic shunts versus endoscopic intervention with or without medical treatment for prevention of… (2020) · Cochrane
no estimate extractedNRNo studies
Transjugular intrahepatic portosystemic shunt vs endoscopic intervention with or without medical treatment
Health‐related quality of life · participants with cirrhosis with previous oesophagogastric variceal bleeding
Portosystemic shunts versus endoscopic intervention with or without medical treatment for prevention of… (2020) · Cochrane
no estimate extractedNRNo studies
Portosystemic shunts vs endoscopic intervention with or without medical treatment
Health‐related quality of life · participants with cirrhosis and with previous oesophagogastric variceal bleeding
Portosystemic shunts versus endoscopic intervention with or without medical treatment for prevention of… (2020) · Cochrane
no estimate extractedNRNo studies
Total shunt vs endoscopic intervention
Health‐related quality of life · participants with cirrhosis and with previous oesophagogastric variceal bleeding
Portosystemic shunts versus endoscopic intervention with or without medical treatment for prevention of… (2020) · Cochrane
no estimate extractedNRNo studies
Percutaneous ethanol injection vs no intervention, other ablation methods, or systemic treatment
Time to mortality · patients with liver metastases
Percutaneous ethanol injection for liver metastases (2020) · Cochrane
no estimate extractedNRNo studies
Percutaneous ethanol injection vs no intervention, other ablation methods, or systemic treatment
Health‐related quality of life · patients with liver metastases
Percutaneous ethanol injection for liver metastases (2020) · Cochrane
no estimate extractedNRNo studies
Percutaneous ethanol injection vs no intervention, other ablation methods, or systemic treatment
Time to progression of liver metastases · patients with liver metastases
Percutaneous ethanol injection for liver metastases (2020) · Cochrane
no estimate extractedNRNo studies
Percutaneous ethanol injection vs no intervention, other ablation methods, or systemic treatment
Serious adverse events and complications · patients with liver metastases
Percutaneous ethanol injection for liver metastases (2020) · Cochrane
no estimate extractedNRNo studies
Transarterial embolisation vs no intervention
Time to progression of liver metastases · people with liver metastases
Transarterial (chemo)embolisation versus no intervention or placebo for liver metastases (2020) · Cochrane
no estimate extractedNRNo studies
Transarterial embolisation vs no intervention
Tumour response measures · people with liver metastases
Transarterial (chemo)embolisation versus no intervention or placebo for liver metastases (2020) · Cochrane
no estimate extractedNRNo studies
Transarterial embolisation vs no intervention
Health‐related quality of life · people with liver metastases
Transarterial (chemo)embolisation versus no intervention or placebo for liver metastases (2020) · Cochrane
no estimate extractedNRNo studies
Transarterial chemoembolisation vs no intervention
Time to progression of liver metastases · people with liver metastases
Transarterial (chemo)embolisation versus no intervention or placebo for liver metastases (2020) · Cochrane
no estimate extractedNRNo studies
Transarterial chemoembolisation vs no intervention
Tumour response measures · people with liver metastases
Transarterial (chemo)embolisation versus no intervention or placebo for liver metastases (2020) · Cochrane
no estimate extractedNRNo studies
Transarterial chemoembolisation vs no intervention
Health‐related quality of life · people with liver metastases
Transarterial (chemo)embolisation versus no intervention or placebo for liver metastases (2020) · Cochrane
no estimate extractedNRNo studies
Transarterial embolisation and transarterial chemoembolisation vs no intervention
Time to progression of liver metastases · people with liver metastases
Transarterial (chemo)embolisation versus no intervention or placebo for liver metastases (2020) · Cochrane
no estimate extractedNRNo studies
Transarterial embolisation and transarterial chemoembolisation vs no intervention
Tumour response measures · people with liver metastases
Transarterial (chemo)embolisation versus no intervention or placebo for liver metastases (2020) · Cochrane
no estimate extractedNRNo studies
Transarterial embolisation and transarterial chemoembolisation vs no intervention
Health‐related quality of life · people with liver metastases
Transarterial (chemo)embolisation versus no intervention or placebo for liver metastases (2020) · Cochrane
no estimate extractedNRNo studies
Radioembolisation plus sorafenib vs sorafenib monotherapy
All‐cause mortality at 1 year · people with hepatocellular carcinoma
Yttrium-90 microsphere radioembolisation for unresectable hepatocellular carcinoma (2020) · Cochrane
no estimate extractedNRNo studies
Radioembolisation vs sorafenib
Cancer‐related mortality · people with hepatocellular carcinoma
Yttrium-90 microsphere radioembolisation for unresectable hepatocellular carcinoma (2020) · Cochrane
no estimate extractedNRNo studies
Radioembolisation vs chemoembolisation
All‐cause mortality at 1 year · people with hepatocellular carcinoma
Yttrium-90 microsphere radioembolisation for unresectable hepatocellular carcinoma (2020) · Cochrane
no estimate extractedNRNo studies
Radioembolisation vs chemoembolisation
Cancer‐related mortality · people with hepatocellular carcinoma
Yttrium-90 microsphere radioembolisation for unresectable hepatocellular carcinoma (2020) · Cochrane
no estimate extractedNRNo studies
Radioembolisation plus sorafenib vs sorafenib monotherapy
Health‐related quality of life · people with hepatocellular carcinoma
Yttrium-90 microsphere radioembolisation for unresectable hepatocellular carcinoma (2020) · Cochrane
no estimate extractedNRNo studies
Radioembolisation plus sorafenib vs sorafenib monotherapy
Cancer‐related mortality · people with hepatocellular carcinoma
Yttrium-90 microsphere radioembolisation for unresectable hepatocellular carcinoma (2020) · Cochrane
no estimate extractedNRNo studies
Radioembolisation plus sorafenib vs sorafenib monotherapy
Time to progression of the tumour (median time to progression) · people with hepatocellular carcinoma
Yttrium-90 microsphere radioembolisation for unresectable hepatocellular carcinoma (2020) · Cochrane
no estimate extractedNRNo studies