Cochrane · systematic review · CD013157
Nutritional supplementation for nonalcohol‐related fatty liver disease: a network meta‐analysis
Komolafe, O, Buzzetti, E, Linden, A, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
48
current version
GRADE rated
46
No studies
2
Included studies
NR
No studies 2 · 4.2%Ungraded 0 · 0%Very low 44 · 91.7%Low 2 · 4.2%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Nutritional supplementation for non‐alcohol‐related fatty liver disease
Population: people with non‐alcohol‐related fatty liver disease (NAFLD)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Interventions | no estimate extracted | NR | No studies |
No active intervention | no estimate extracted | NR | No studies |
Other supplements(12 trials; 650 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Prebiotics/Probiotics/Synbiotics(15 trials; 763 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
PUFA(9 trials; 750 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Vitamin E(4 trials; 379 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other antioxidants(3 trials; 191 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Vitamin D(4 trials; 241 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Amino acids(2 trials; 158 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Vitamin E plus other antioxidants(1 trial; 36 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other antioxidants plus other supplements(1 trial; 46 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other supplements(2 RCT; 136 participants) | OR 2.39 [0.24, 75.94] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
PUFA(3 RCT; 301 participants) | OR 1.31 [0.49, 4] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Vitamin E(2 RCT; 235 participants) | OR 0.79 [0.35, 1.77] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Vitamin D(1 RCT; 18 participants) | OR 1.3 [0.03, 58.38] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other antioxidants(1 RCT; 99 participants) | OR 1.67 [0.24, 14.73] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Prebiotics/Probiotics/Synbiotics(14 trials; 649 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Amino acids(2 trials; 98 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
PUFA plus vitamin E(1 trial; 70 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Vitamin C plus vitamin E(1 trial; 88 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Amino acids plus vitamin C(1 trial; 191 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Oestrogen(1 trial; 78 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Phospholipids plus PUFA plus vitamin E(1 trial; 40 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Phospholipids plus vitamin E plus other antioxidants(1 trial; 138 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Polysaccharides(1 trial; 23 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
PUFA plus other supplements(1 trial; 38 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Vitamin E(1 RCT; 68 participants) | Rate ratio 1.46 [0.48, 4.98] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
PUFA(2 trials; 58 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Amino acids(1 trial; 78 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other supplements(12 trials; 864 participants) | OR 1.33 [0.78, 2.26] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Prebiotics/Probiotics/Synbiotics(5 trials; 243 participants) | OR 0.67 [0.3, 1.46] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Polyunsaturated fatty acids(5 trials; 252 participants) | OR 4.44 [2.4, 8.48] | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
Vitamin E(1 RCT; 97 participants) | OR 0.83 [0.36, 1.91] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Amino acids(2 RCT; 152 participants) | OR 0.61 [0.28, 1.28] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Phospholipids(No direct RCT) | OR 0.37 [0.04, 2.01] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Amino acids + vitamin C(1 RCT; 191 participants) | OR 1.76 [0.62, 5.53] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Oestrogen(1 RCT; 78 participants) | OR 1.11 [0.03, 44.88] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Vitamin D(1 trial; 60 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other supplements(6 RCTs; 291 participants) | Rate ratio 1.72 [1.25, 2.4] | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
Polyunsaturated fatty acids(2 RCTs; 252 participants) | Rate ratio 0.9 [0.68, 1.21] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Vitamin E(3 RCTs; 332 participants) | Rate ratio 0.91 [0.71, 1.18] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Amino acids(1 RCT; 78 participants) | Rate ratio 0.81 [0.42, 1.54] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other supplements(7 trials; 396 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Prebiotics/Probiotics/Synbiotics(6 trials; 318 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
PUFA(2 trials; 95 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Vitamin E(1 trial; 167 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Prebiotics/Probiotics/Synbiotics(6 trials; 296 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Prebiotics/Probiotics/Synbiotics(5 trials; 289 participants) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |