Cochrane · systematic review · CD014960
Antibiotics for treatment of leptospirosis
Win, TZ, Han, SM, Edwards, T, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
11
No studies
1
Included studies
NR
No studies 1 · 8.3%Ungraded 0 · 0%Very low 11 · 91.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ Antibiotics compared with placebo or no intervention for treatment of leptospirosis
Population: people with leptospirosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Summary of findings table ‐ Antibiotics vs placebo or no intervention | RR 1.57 [0.65, 3.79] | 3 studies · 367 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse event ‐ not reported Summary of findings table ‐ Antibiotics vs placebo or no intervention | no estimate extracted | NR | No studies |
Adverse events considered non‐serious Summary of findings table ‐ Antibiotics vs placebo or no intervention | RR 1.05 [0.35, 3.17] | 2 studies · 162 participants | Very low Downgraded: risk of bias, imprecision |
Summary of findings table ‐ Antibiotics compared with other antibiotics for people with leptospirosis
Population: people with leptospirosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality (penicillin versus a cephalosporin (cefotaxime or ceftriaxone)) Summary of findings table ‐ Antibiotics vs other antibiotics | RR 1.38 [0.47, 4.04] | 2 studies · 348 participants | Very low Downgraded: risk of bias, imprecision |
All‐cause mortality (penicillin versus doxycycline) Summary of findings table ‐ Antibiotics vs other antibiotics | RR 0.93 [0.13, 6.46] | 1 study · 168 participants | Very low Downgraded: risk of bias, imprecision |
All‐cause mortality (a cephalosporin (cefotaxime) versus doxycycline) Summary of findings table ‐ Antibiotics vs other antibiotics | RR 0.18 [0.01, 3.78] | 1 study · 169 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events (nosocomial infection) (penicillin versus cefotaxime) Summary of findings table ‐ Antibiotics vs other antibiotics | RR 1.01 [0.15, 7.02] | 1 study · 175 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events (nosocomial infection) (penicillin versus doxycycline) Summary of findings table ‐ Antibiotics vs other antibiotics | RR 0.62 [0.11, 3.62] | 1 study · 168 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events (nosocomial infection) (doxycycline versus cefotaxime) Summary of findings table ‐ Antibiotics vs other antibiotics | RR 1.01 [0.15, 7.02] | 1 study · 175 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events considered non‐serious (penicillin versus cefotaxime) Summary of findings table ‐ Antibiotics vs other antibiotics | RR 3.03 [0.13, 73.47] | 1 study · 175 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events considered non‐serious (penicillin versus doxycycline) Summary of findings table ‐ Antibiotics vs other antibiotics | RR 2.8 [0.12, 67.66] | 1 study · 168 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events considered non‐serious (penicillin versus chloramphenicol) Summary of findings table ‐ Antibiotics vs other antibiotics | RR 0.74 [0.15, 3.67] | 1 study · 52 participants | Very low Downgraded: risk of bias, imprecision |