Acute necrotizing ulcerative gingivitis/periodontitis (WHO clinical stage 3) · Children or adolescents
No eligible studies reported acute necrotizing ulcerative gingivitis/periodontitis.
1 finding from 1 review
Chronic herpes simplex infection (WHO clinical stage 4) · Children or adolescents
No eligible studies reported chronic herpes simplex infection.
1 finding from 1 review
Treatment failure (planned; no eligible studies) · Children with carious primary teeth after vital or non-vital pulp therapy
No eligible studies were found evaluating bio-active restorative materials for restoring carious primary teeth after pulp therapy.
1 finding from 1 review
Sex/gender differences in fluoride intake or dental-care-product contribution · Participants stratified by sex/gender (especially young children)
No study has taken sex/gender into account when assessing fluoride intake, especially in young children.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Hypertension (later in life) · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
No eligible studies examined the influence of complementary feeding practices on later hypertension; this is an evidence gap.
1 finding from 1 review
Not applicable (no eligible studies) · Children with carious primary teeth (no pulp therapy)
No eligible RCTs assessed new bio-active restorative materials in carious primary teeth; this is an evidence gap identified by the review.
1 finding from 1 review
Choking · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
No systematic reviews or studies assessed choking risk for RCF or NRCF (only BLW/BLISS); this is an evidence gap.
1 finding from 1 review
Oral hairy leukoplakia prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No eligible studies compared oral hairy leukoplakia between different ART regimens.
1 finding from 1 review
Diet-related noncommunicable diseases · Children and adolescents (general population, aged under 20 years)
No eligible studies were found.
1 finding from 1 review
Contribution of dental care products to total fluoride exposure · Pregnant and lactating women
No study has explored the contribution of dental care products to total fluoride exposure in pregnant and lactating women.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Dental caries · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
No eligible studies examined the influence of complementary feeding practices on later dental caries; this is an evidence gap.
1 finding from 1 review
Occlusal caries detection accuracy · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces
No eligible QLF studies met the meta-analysis inclusion criteria (candidate QLF studies were identified but none had acceptable index/reference tests and reporting quality).
1 finding from 1 review
no estimate extracted
0 studies
No studies found
detection of proximal caries · Permanent posterior teeth, proximal surfaces (in vitro extracted teeth and in vivo patients)
For fibre-optic transillumination (FOTI), studies were identified (in vitro N=4, in vivo N=3) but none had sufficiently low risk of bias and adequate reporting to be pooled; no meta-analytic estimate could be derived.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Salivary osmolality (hydration level) · Patients with drooling (sialorrhea) due to neurological disease
No included study reported salivary osmolality; this pre-planned outcome remains unassessed (no studies).
1 finding from 1 review
Oral/pharyngeal microbiota modifications · Adults with gastroesophageal reflux disease (GERD) or laryngopharyngeal reflux (LPR)
No eligible studies investigated reflux-related modifications of the oral or pharyngeal microbiota; this is an evidence gap identified by the review.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Any planned outcome (sealant retention, caries, etc.) · Patients with premolars/molars requiring pit-and-fissure sealants
No eligible studies compared laser preparation with enameloplasty for fissure sealant placement (evidence gap).
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Any planned outcome (sealant retention, caries, etc.) · Patients with premolars/molars requiring pit-and-fissure sealants
No eligible studies compared laser preparation with air abrasion for fissure sealant placement (evidence gap).
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Dental erosive wear · Children and adolescents with juvenile idiopathic arthritis (JIA)
No eligible studies reported dental erosive wear, so its association with JIA could not be assessed (evidence gap).
1 finding from 1 review
Dental caries in permanent teeth · Children and adolescents with permanent dentition
No eligible studies examined prenatal tobacco exposure and caries in permanent dentition.
1 finding from 1 review