Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,949 questions · 1,994 findings · 636 reviews

No studies found 504 · 25.3%GRADE not reported 340 · 17.1%Very low 477 · 23.9%Low 390 · 19.6%Moderate 241 · 12.1%High 42 · 2.1%

ASENAPINE vs placebo

Adverse effects: Incidence of serious adverse effects · adults with schizophrenia

It is very uncertain whether ASENAPINE changes adverse effects: Incidence of serious adverse effects compared with PLACEBO (very low certainty).

1 finding from 1 review

Pilocarpine vs placebo

Adverse effects (side effects; treatment withdrawals) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review

Pilocarpine vs Artificial saliva

Adverse effects (side effects; treatment withdrawals) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review

Acupuncture vs STANDARD DOSE ANTIPSYCHOTICS

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

ACUPUNCTURE may leads to lower adverse effects: Extrapyramidal symptoms (short‐term) compared with STANDARD DOSE ANTIPSYCHOTICS (low certainty).

1 finding from 1 review

Antihistamines vs antiemetics

Adverse effects: impaired cognition and blurred vision · patients with motion sickness

The review found no eligible studies for this question.

1 finding from 1 review

Group A: amino acids vs placebo

Adverse effects: suicidal thoughts (events) · people in the prodromal stage of psychosis

It is very uncertain whether group A: amino acids changes adverse effects: suicidal thoughts Short‐term (events) compared with placebo (very low certainty).

1 finding from 1 review

TNF‐α blockers intervention vs placebo or additional treatment

Adverse effects after treatment initiation: infections · children diagnosed with Kawasaki disease

TNF‐α blockers intervention showed no clear difference in adverse effects after treatment initiation: infections compared with placebo or additional treatment (low certainty).

1 finding from 1 review

FLUPHENAZINE (ORAL) vs placebo

Adverse effects: Death ‐ long termOccurrences of death · patients with schizophrenia

ORAL FLUPHENAZINE showed no clear difference in adverse effects: Death ‐ long termOccurrences of death compared with PLACEBO (low certainty).

1 finding from 1 review