Cochrane · systematic review · CD012715
Antihistamines for motion sickness
Karrim, N, Byrne, R, Magula, N, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
ENTAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
24
current version
GRADE rated
13
No studies
11
Included studies
NR
No studies 11 · 45.8%Ungraded 0 · 0%Very low 6 · 25%Low 6 · 25%Moderate 1 · 4.2%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antihistamines versus placebo for motion sickness
Population: patients with motion sickness
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of susceptible participants who did not experience any motion sickness symptoms under natural conditions Assessed by: self‐reported questionnaires6,7 Antihistamines vs placebo | RR 1.81 [1.23, 2.66] | 3 studies · 240 participants | Moderate Downgraded: risk of bias, imprecision |
Proportion of susceptible participants who did not experience any motion sickness symptoms under experimental conditions Assessed by: rotating chair Antihistamines vs placebo | no estimate extracted | 2 studies · 62 participants | Very low Downgraded: risk of bias, imprecision |
Proportion of susceptible participants who experienced a reduction or resolution of existing motion sickness symptoms Antihistamines vs placebo | no estimate extracted | NR | No studies |
Physiological measures: heart rate and core temperature Antihistamines vs placebo | no estimate extracted | NR | No studies |
Physiological measures: gastric tachyarrhythmia10 Assessed by: electrogastrography Antihistamines vs placebo | no estimate extracted | 1 study · 42 participants | Low Downgraded: imprecision |
Adverse effects: sedation Assessed by: adverse effect questionnaire (presence or absence given numerical values) Antihistamines vs placebo | RR 1.51 [1.12, 2.02] | 2 studies · 190 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects: impaired cognition Assessed by: adverse effect questionnaire (presence or absence given numerical values) Antihistamines vs placebo | RR 0.89 [0.58, 1.38] | 2 studies · 190 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects: blurred vision Assessed by: adverse effect questionnaire (presence or absence given numerical values) Antihistamines vs placebo | RR 1.14 [0.53, 2.48] | 2 studies · 190 participants | Low Downgraded: risk of bias, imprecision |
Antihistamines versus scopolamine for motion sickness
Population: patients with motion sickness
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of susceptible participants who did not experience any motion sickness symptoms under natural conditions Assessed by: self‐reported questionnaires6,7 Antihistamines vs scopolamine | RR 0.89 [0.68, 1.16] | 2 studies · 71 participants | Very low Downgraded: risk of bias, imprecision |
Proportion of susceptible participants who experienced a reduction or resolution of existing motion sickness symptoms Antihistamines vs scopolamine | no estimate extracted | NR | No studies |
Physiological measures: heart rate Assessed by: self‐measured (participant measured own pulse rate) Antihistamines vs scopolamine | no estimate extracted | 1 study · 20 participants | Very low Downgraded: risk of bias, imprecision |
Physiological measures: core temperature and gastric tachyarrhythmia (electrogastrography) Antihistamines vs scopolamine | no estimate extracted | NR | No studies |
Adverse effects: sedation Assessed by: self‐reported Antihistamines vs scopolamine | RR 0.82 [0.07, 9.25] | 2 studies · 90 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse effects: impaired cognitive function Antihistamines vs scopolamine | no estimate extracted | NR | No studies |
Adverse effects: blurred vision Assessed by: self‐reported Antihistamines vs scopolamine | no estimate extracted | 1 study · 51 participants | Very low Downgraded: risk of bias, imprecision |
Antihistamines versus antiemetics for motion sickness
Population: patients with motion sickness
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of susceptible participants who did not experience any motion sickness symptoms under experimental conditions Assessed by: calculated based on head movements tolerated (rotating chair); MSAQ Antihistamines vs antiemetics | no estimate extracted | 1 study · 42 participants | Low Downgraded: imprecision |
Proportion of susceptible participants who experienced a reduction or resolution of existing motion sickness symptoms Antihistamines vs antiemetics | no estimate extracted | NR | No studies |
Physiological measures: heart rate and core temperature Antihistamines vs antiemetics | no estimate extracted | NR | No studies |
Physiological measures: gastric tachyarrhythmia2 Assessed by: electrogastrography Antihistamines vs antiemetics | no estimate extracted | 1 study · 42 participants | Low Downgraded: imprecision |
Adverse effects: impaired cognition and blurred vision Antihistamines vs antiemetics | no estimate extracted | NR | No studies |
Antihistamines versus acupuncture for motion sickness
Population: patients with motion sickness
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of susceptible participants who did not experience any motion sickness symptoms under experimental conditions Assessed by: Graybiel motion sickness scale Antihistamines vs acupuncture | RR 1.32 [1.12, 1.57] | 1 study · 100 participants | Very low Downgraded: risk of bias, imprecision |
Proportion of susceptible participants who experienced a reduction or resolution of existing motion sickness symptoms Antihistamines vs acupuncture | no estimate extracted | NR | No studies |
Physiological measures: heart rate, core temperature and gastric tachyarrhythmia (electrogastrography) Antihistamines vs acupuncture | no estimate extracted | NR | No studies |
Adverse effects: sedation, impaired cognitive function, blurred vision Antihistamines vs acupuncture | no estimate extracted | NR | No studies |