Cochrane · systematic review · CD011458
Asenapine versus placebo for schizophrenia
Hay, A, Byers, A, Sereno, M, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 28.6%Ungraded 0 · 0%Very low 4 · 57.1%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
ASENAPINE versus PLACEBO for schizophrenia
Population: adults with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global state: No clinically important change CGI‐I ASENAPINE vs PLACEBO | RR 0.81 [0.68, 0.97] | 1 study · 336 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Mental state: No clinically important change PANSS ASENAPINE vs PLACEBO | RR 0.72 [0.59, 0.86] | 1 study · 336 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Mental state: Average change score in negative symptoms PANSS Marder negative factor score ASENAPINE vs PLACEBO | no estimate extracted | 1 study · 336 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Adverse effects: Incidence of serious adverse effects ASENAPINE vs PLACEBO | RR 0.29 [0.14, 0.63] | 1 study · 386 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse effects: Clinically significant extrapyramidal symptoms AIMS ASENAPINE vs PLACEBO | no estimate extracted | NR | No studies |
Leaving the study early ‐ any reason ASENAPINE vs PLACEBO | RR 0.91 [0.8, 1.04] | 5 studies · 1046 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Economic costs ASENAPINE vs PLACEBO | no estimate extracted | NR | No studies |