Cochrane · systematic review · CD012448
TNF‐α blockers for the treatment of Kawasaki disease in children
Yamaji, N, da Silva Lopes, K, Shoda, T, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
VascularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 2 · 28.6%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
TNF‐α blockers intervention compared to placebo or additional treatment for children with Kawasaki disease
Population: children with Kawasaki disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment resistance TNF‐α blockers intervention vs placebo or additional treatment | RR 0.57 [0.38, 0.86] | 5 studies · 494 participants | Low Downgraded: risk of bias, imprecision |
Incidence of coronary artery abnormalities TNF‐α blockers intervention vs placebo or additional treatment | RR 1.18 [0.45, 3.12] | 3 studies · 270 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects after treatment initiation: infusion reactions TNF‐α blockers intervention vs placebo or additional treatment | RR 0.06 [0.01, 0.45] | 3 studies · 250 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects after treatment initiation: infections TNF‐α blockers intervention vs placebo or additional treatment | RR 0.68 [0.33, 1.37] | 2 studies · 227 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects after treatment initiation: cutaneous reactions (rash) TNF‐α blockers intervention vs placebo or additional treatment | RR 4.71 [0.24, 90.69] | 1 study · 31 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effects after treatment initiation: cutaneous reactions (contact dermatitis) TNF‐α blockers intervention vs placebo or additional treatment | RR 0.31 [0.04, 2.68] | 1 study · 31 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effects after treatment initiation: injection site reactions, neutropenia, infections, demyelinating disease, heart failure, malignancy, and induction of autoimmunity. TNF‐α blockers intervention vs placebo or additional treatment | no estimate extracted | NR | No studies |