Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by Advanced, pharmacological and complementary interventions for chronic or recurrent orofacial pain conditions: a systematic evidence map…. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| Randomised controlled trial of arthrocentesis with or without PRF for internal derangement of the TMJ. Karadayi 2021 · Karadayi Ugur, Gursoytrak Burcu · Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery PMID:33581954 | 2021 | 5 | 2 | not extracted yet |
| Effectiveness of Photobiomodulation in Temporomandibular Disorder-Related Pain Using a 635 nm Diode Laser: A Randomized, Blinded, and… Monteiro 2020 · Monteiro Luís, Ferreira Raquel, et al. · Photobiomodulation, photomedicine, and laser surgery PMID:32427553 | 2020 | 5 | none stated | not extracted yet |
| Wang 2021 matched by author and year (probable) | NR | 5 | 1 | not extracted yet |
| Short-term transcutaneous electrical nerve stimulation reduces pain and improves the masticatory muscle activity in temporomandibular disorder… Ferreira 2017 · Ferreira Ana Paula de Lima, Costa Dayse Regina Alves da, et al. · Journal of applied oral science : revista FOB PMID:28403351 | 2017 | 4 | none stated | not extracted yet |
| Is arthrocentesis plus platelet-rich plasma superior to arthrocentesis plus hyaluronic acid for the treatment of temporomandibular joint… Kilic 2016 · Cömert Kiliç S, Güngörmüş M · International journal of oral and maxillofacial surgery PMID:27364372 | 2016 | 4 | 5 | not extracted yet |
| Does intra-articular injection of tenoxicam after arthrocentesis heal outcomes of temporomandibular joint osteoarthritis? A randomized clinical trial. Bayramoglu 2023 · Bayramoglu Zeynep, Yavuz Günay Yapici, et al. · BMC oral health PMID:36890529 | 2023 | 3 | 2 | not extracted yet |
| Effect of Non-Ablative Non-Thermal CO2 Laser on Drug-Resistant Trigeminal Neuralgia: A Pilot Study. Rezazadeh 2023 · Rezazadeh Fahimeh, Borhani-Haghighi Afshin, et al. · Photobiomodulation, photomedicine, and laser surgery PMID:37335618 | 2023 | 3 | none stated | not extracted yet |
| Arthrocentesis, Injectable Platelet-Rich Plasma and Combination of Both Protocols of Temporomandibular Joint Disorders Management: A Single-Blinded… Abbadi 2022 · Abbadi Wael, Kara Beit Zafin, et al. · Cureus PMID:36523721 | 2022 | 3 | 4 | not extracted yet |
| Randomised controlled trial of arthrocentesis with or without PRF for internal derangement of the TMJ Karadayi 2021 · Karadayi Ugur, Gursoytrak Burcu · Journal of Cranio-Maxillofacial Surgery DOI:10.1016/j.jcms.2021.01.018 | 2021 | 3 | 3 | not extracted yet |
| Does glucosamine, chondroitin sulfate, and methylsulfonylmethane supplementation improve the outcome of temporomandibular joint osteoarthritis… Cömert Kılıç 2021 · Cömert Kılıç Songül · Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery PMID:33685850 | 2021 | 3 | none stated | not extracted yet |
| Effect of photobiomodulation therapy on painful temporomandibular disorders. Aisaiti 2021 · Aisaiti Adila, Zhou Yanli, et al. · Scientific reports PMID:33907210 | 2021 | 3 | none stated | not extracted yet |
| Intraoral photobiomodulation diminishes pain and improves functioning in women with temporomandibular disorder: a randomized, sham-controlled,… Herpich 2020 · Herpich Carolina Marciela, Leal-Junior Ernesto Cesar Pinto, et al. · Lasers in medical science PMID:31325122 | 2020 | 3 | none stated | not extracted yet |
| Is Arthrocentesis Plus Platelet-Rich Plasma Superior to Arthrocentesis Alone in the Treatment of Temporomandibular Joint Osteoarthritis? A… Cömert Kiliç 2015 · Cömert Kiliç Songül, Güngörmüş Metin, et al. · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons PMID:25976690 | 2015 | 3 | none stated | not extracted yet |
| Two doses of botulinum toxin type A for the treatment of trigeminal neuralgia: observation of therapeutic effect from a randomized, double-blind,… Zhang 2014 · Zhang Haifeng, Lian Yajun, et al. · The journal of headache and pain PMID:25263254 | 2014 | 3 | none stated | not extracted yet |
| Botulinum toxin-type A: could it be an effective treatment option in intractable trigeminal neuralgia? Shehata 2013 · Shehata Hatem S, El-Tamawy Mohamed S, et al. · The journal of headache and pain PMID:24251833 | 2013 | 3 | none stated | not extracted yet |
| Botulinum toxin type A for the treatment of trigeminal neuralgia: results from a randomized, double-blind, placebo-controlled trial. Wu 2012 · Wu Chuan-Jie, Lian Ya-Jun, et al. · Cephalalgia : an international journal of headache PMID:22492424 | 2012 | 3 | none stated | not extracted yet |
| Effectiveness of dry needling for the treatment of temporomandibular myofascial pain: a double-blind, randomized, placebo controlled study. Dıracoglu 2012 · Dıraçoğlu Demirhan, Vural Meltem, et al. · Journal of back and musculoskeletal rehabilitation PMID:23220812 | 2012 | 3 | none stated | not extracted yet |
| Low-level laser therapy for treatment of temporomandibular joint pain: a double-blind and placebo-controlled trial. Emshoff 2008 · Emshoff Rüdiger, Bösch Renato, et al. · Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics PMID:18329580 | 2008 | 3 | none stated | not extracted yet |
| Single intra-articular administration of injectable platelet-rich fibrin (I-PRF) in alleviating temporomandibular joint pain: A pilot clinical trial Sielski 2025 · Sielski Marcin, Chęcińska Kamila, et al. · Dental and Medical Problems DOI:10.17219/dmp/188273 | 2025 | 2 | none stated | not extracted yet |
| Piano level laser therapy versus epidermal growth factor injection for painful myogenic temporomandibular disorder (a randomized clinical trial). Qataya 2025 · Qataya Passant Osama, Zaki Azza Mohamed, et al. · Clinical oral investigations PMID:39912963 | 2025 | 2 | none stated | not extracted yet |
| Double-Puncture Arthrocentesis in Arthrogenous TMJ Disorders: Bioviscosupplementation vs. Viscosupplementation a Randomized Controlled Trial. Ângelo 2025 · Ângelo David Faustino, Cardoso Henrique José, et al. · Journal of clinical medicine PMID:40507514 | 2025 | 2 | none stated | not extracted yet |
| Ultrasound-Guided Vs Non-Guided Prolotherapy for Internal Derangement of Temporomandibular Joint. A Randomized Clinical Trial. Kheder 2024 · Alhaj Kheder Mohammad Badr, Kandil Nour Mohamed, et al. · Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine PMID:38581185 | 2024 | 2 | none stated | not extracted yet |
| Platelet-Rich Plasma in the Management of Temporomandibular Joint Pain in Young Adults With Temporomandibular Disorder. Mathpati 2024 · Mathpati Santosh Kumar, Jain Gourav, et al. · Cureus PMID:38586782 | 2024 | 2 | 2 | not extracted yet |
| Effect of acupuncture for temporomandibular disorders: a randomized clinical trial. Liu 2024 · Liu Lu, Chen Qiuyi, et al. · QJM : monthly journal of the Association of Physicians PMID:38710498 | 2024 | 2 | none stated | not extracted yet |
| Electroacupuncture and carbamazepine for patients with trigeminal neuralgia: a randomized, controlled, 2 × 2 factorial trial. Li 2024 · Li Rongrong, Sun Jing, et al. · Journal of neurology PMID:38816482 | 2024 | 2 | none stated | not extracted yet |
| Effects of adding electro-massage to manual therapy for the treatment of individuals with myofascial temporomandibular pain: a randomized controlled… Espejo-Antúnez 2024 · Espejo-Antúnez Luis, Cardero-Durán María de Los Ángeles, et al. · Journal of applied oral science : revista FOB PMID:39292112 | 2024 | 2 | none stated | not extracted yet |
| Manual therapy and dry needling improve mobility, pain and reduce fear of COVID-19 in temporomandibular disorder patients: Randomized controlled… Ferreira 2024 · Ferreira Caio César Quintiliano, Lima Karen Rodrigues, et al. · Journal of bodywork and movement therapies PMID:39593654 | 2024 | 2 | none stated | not extracted yet |
| Clinical Efficacy of Two Different Low-Level Laser Therapies for the Treatment of Trigeminal Neuralgia: A Randomized, Placebo-Controlled Trial. Karagozoglu 2024 · Karagözoğlu İrem, Demirkol Nermin, et al. · Journal of clinical medicine PMID:39598034 | 2024 | 2 | 1 | not extracted yet |
| Evaluation of the efficiency of hyaluronic acid, PRP and I-PRF intra-articular injections in the treatment of internal derangement of the… Vingender 2023 · Vingender Szonja, Dőri Ferenc, et al. · Journal of Cranio-Maxillofacial Surgery DOI:10.1016/j.jcms.2023.01.017 | 2023 | 2 | none stated | not extracted yet |
| Percutaneous Radiofrequency Ablation for Trigeminal Neuralgia Management: A Randomized, Double-Blinded, Sham-Controlled Clinical Trial. Mansano 2023 · Mansano André Marques, Frederico Thiago Nouer, et al. · Pain medicine (Malden, Mass.) PMID:36029256 | 2023 | 2 | none stated | not extracted yet |
| Effectiveness of Dry Needling versus Manual Therapy in Myofascial Temporomandibular Disorders: A Single-Blind Randomized Controlled Trial. García-de la-Banda-García 2023 · García-de la-Banda-García Rocío, Cortés-Pérez Irene, et al. · Journal of personalized medicine PMID:37763182 | 2023 | 2 | 2 | not extracted yet |
| Effectiveness of high-intensity laser therapy in patients with myogenic temporomandibular joint disorder: A double-blind, placebo-controlled study. Ekici 2022 · Ekici Ömer, Dündar Ümit, et al. · Journal of stomatology, oral and maxillofacial surgery PMID:34174507 | 2022 | 2 | none stated | not extracted yet |
| Efficacy of Platelet-Rich Plasma Versus Hyaluronic Acid Following Arthrocentesis for Temporomandibular Joint Disc Disorders: A Randomized Controlled… Jacob 2022 · Jacob Shiju Mathew, Bandyopadhyay Tapas Kumar, et al. · Journal of maxillofacial and oral surgery PMID:36896087 | 2022 | 2 | none stated | not extracted yet |
| Effect of photobiomodulation therapy on painful temporomandibular disorders Aisaiti 2021 · Aisaiti Adila, Zhou Yanli, et al. · Scientific Reports DOI:10.1038/s41598-021-87265-0 | 2021 | 2 | 1 | not extracted yet |
| Evaluation of the efficacy of a new low-level laser therapy home protocol in the treatment of temporomandibular joint disorder-related pain: A… Del Vecchio 2021 · Del Vecchio Alessandro, Floravanti Miriam, et al. · Cranio : the journal of craniomandibular practice PMID:30999823 | 2021 | 2 | none stated | not extracted yet |
| Evaluation of Arthrocentesis with and Without Platelet-Rich Plasma in the Management of Internal Derangement of Temporomandibular Joint: A… Singh 2021 · Singh Akhilesh Kumar, Sharma Naresh Kumar, et al. · Journal of maxillofacial and oral surgery PMID:33927494 | 2021 | 2 | none stated | not extracted yet |
| Effects of low-level laser therapy versus soft occlusive splints on mouth opening and surface electromyography in females with temporomandibular… Shousha 2021 · Shousha Tamer, Alayat Mohamed, et al. · PloS one PMID:34597318 | 2021 | 2 | none stated | not extracted yet |
| Effectiveness of Photobiomodulation in Temporomandibular Disorder-Related Pain Using a 635 nm Diode Laser: A Randomized, Blinded, and… Monteiro 2020 · Monteiro Luís, Ferreira Raquel, et al. · Photobiomodulation, Photomedicine, and Laser Surgery DOI:10.1089/photob.2019.4730 | 2020 | 2 | 1 | not extracted yet |
| Efficacy of dry needling in patients with myofascial temporomandibular disorders related to the masseter muscle. Özden 2020 · Özden Mehmet Cem, Atalay Berkem, et al. · Cranio : the journal of craniomandibular practice PMID:30296920 | 2020 | 2 | none stated | not extracted yet |
| Photobiomodulation Therapy for Myofascial Pain in Temporomandibular Joint Dysfunction: A Double-Blinded Randomized Clinical Trial. Nadershah 2020 · Nadershah Mohammed, Abdel-Alim Hala M, et al. · Journal of maxillofacial and oral surgery PMID:31988570 | 2020 | 2 | none stated | not extracted yet |
| Intraoral photobiomodulation diminishes pain and improves functioning in women with temporomandibular disorder: a randomized, sham-controlled,… Herpich 2020 · Herpich Carolina Marciela, Leal-Junior Ernesto Cesar Pinto, et al. · Lasers in Medical Science DOI:10.1007/s10103-019-02841-1 | 2019 | 2 | 2 | not extracted yet |
| Evaluation of the efficacy of a new low-level laser therapy home protocol in the treatment of temporomandibular joint disorder-related pain: A… Del Vecchio 2019 · Del Vecchio Alessandro, Floravanti Miriam, et al. · CRANIO® DOI:10.1080/08869634.2019.1599174 | 2019 | 2 | 1 | not extracted yet |
| Non-specific effects and clusters of women with painful TMD responders and non-responders to LLLT: double-blind randomized clinical trial. Magri 2018 · Magri Laís Valencise, Carvalho Vinícius Almeida, et al. · Lasers in medical science PMID:29209867 | 2018 | 2 | none stated | not extracted yet |
| Comparative effectiveness of photobiomodulation and manual therapy alone or combined in TMD patients: a randomized clinical trial. Brochado 2018 · Brochado Fernanda Thomé, Jesus Luciano Henrique de, et al. · Brazilian oral research PMID:29995062 | 2018 | 2 | none stated | not extracted yet |
| Short-term transcutaneous electrical nerve stimulation reduces pain and improves the masticatory muscle activity in temporomandibular disorder… Ferreira 2016 · FERREIRA Ana Paula de Lima, COSTA Dayse Regina Alves da, et al. · Journal of Applied Oral Science DOI:10.1590/1678-77572016-0173 | 2017 | 2 | none stated | not extracted yet |
| Is dextrose prolotherapy superior to placebo for the treatment of temporomandibular joint hypermobility? A randomized clinical trial. Cömert Kiliç 2016 · Cömert Kiliç S, Güngörmüş M · International journal of oral and maxillofacial surgery PMID:26846795 | 2016 | 2 | none stated | not extracted yet |
| Patient-conducted anodal transcranial direct current stimulation of the motor cortex alleviates pain in trigeminal neuralgia. Hagenacker 2014 · Hagenacker Tim, Bude Vera, et al. · The journal of headache and pain PMID:25424567 | 2014 | 2 | none stated | not extracted yet |
| Low level laser effects on pain to palpation and electromyographic activity in TMD patients: a double-blind, randomized, placebo-controlled study. Venezian 2010 · Venezian Giovana Cherubini, da Silva Marco Antônio Moreira Rodrigues, et al. · Cranio : the journal of craniomandibular practice PMID:20491229 | 2010 | 2 | none stated | not extracted yet |
| Low intensity laser therapy in the treatment of temporomandibular disorders: a double-blind study. Venancio 2005 · Venancio R de Abreu, Camparis C M, et al. · Journal of oral rehabilitation PMID:16202043 | 2005 | 2 | none stated | not extracted yet |
| Topical clonazepam in stomatodynia: a randomised placebo-controlled study. Gremeau-Richard 2004 · Gremeau-Richard Christelle, Woda Alain, et al. · Pain PMID:15109507 | 2004 | 2 | none stated | not extracted yet |