Primary study · included by 2 reviews

Evaluation of the efficacy of a new low-level laser therapy home protocol in the treatment of temporomandibular joint disorder-related pain: A randomized, double-blind, placebo-controlled clinical trial

Del Vecchio 2019 · Del Vecchio Alessandro, Floravanti Miriam, Boccassini Armando, et al. · CRANIO® · 2019

Included by

Advanced, pharmacological and complementary interventions for chronic or recurrent orofacial pain conditions: a systematic evidence map with selective meta-analyses.
Non-Cochrane · intervention · 2026 · cited as Del Vecchio 2021 · Reference list (ref 70); Supplementary Table 4
Outcome this study informsPooled effectEvidenceCertainty
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Short-term (immediate post-intervention to 4 weeks)
SMD -0.62 [-1.14, -0.10]9 studiesGRADE not reported
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Mid-term (>4 to 12 weeks)
SMD -0.35 [-5.69, 4.99]2 studiesGRADE not reported
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Mid-term (>4 to 12 weeks)
SMD -1.41 [-9.02, 6.20]2 studiesGRADE not reported
Pain intensity
Photobiomodulation / low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Mid-term (more than 4 to 12 weeks)
SMD -0.91 [-3.47, 1.65]3 studies · 82 participantsGRADE not reported
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Short-term (immediate post-intervention to 4 weeks)
SMD -0.50 [-1.14, 0.14]9 studiesGRADE not reported
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Short-term (immediate post-intervention to 4 weeks)
SMD -0.16 [-0.68, 0.37]9 studiesGRADE not reported
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Short-term (immediate post-intervention to 4 weeks)
SMD -0.41 [-1.06, 0.24]9 studiesGRADE not reported
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Mid-term (>4 to 12 weeks)
SMD -0.91 [-3.47, 1.65]3 studies · 82 participantsVery low
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Short-term (immediate post-intervention to 4 weeks)
SMD -0.35 [-1.03, 0.34]9 studiesGRADE not reported
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Short-term (immediate post-intervention to 4 weeks)
SMD -0.40 [-1.26, 0.46]NRGRADE not reported
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Short-term (immediate post-intervention to 4 weeks)
SMD -0.52 [-1.20, 0.16]9 studiesGRADE not reported
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Mid-term (>4 to 12 weeks)
SMD -0.91 [-3.47, 1.65]NRGRADE not reported
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Mid-term (>4 to 12 weeks)
SMD -0.97 [-13.95, 12.00]2 studiesGRADE not reported
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Short-term (immediate post-intervention to 4 weeks)
SMD -0.45 [-1.06, 0.17]10 studies · 462 participantsVery low
Pain intensity
Photobiomodulation / low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Short-term (immediate to 4 weeks)
SMD -0.45 [-1.06, 0.17]10 studies · 462 participantsGRADE not reported
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Short-term (immediate post-intervention to 4 weeks)
SMD -0.49 [-1.18, 0.20]9 studiesGRADE not reported
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Short-term (immediate post-intervention to 4 weeks)
SMD -0.49 [-1.14, 0.15]9 studiesGRADE not reported
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Short-term (immediate post-intervention to 4 weeks)
SMD -0.51 [-1.24, 0.22]9 studiesGRADE not reported
Pain intensity
Photobiomodulation / low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Mid-term (more than 4 to 12 weeks)
SMD -0.71 [-1.09, -0.33]3 studies · 82 participantsGRADE not reported
Pain intensity
Photobiomodulation or low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Short-term (immediate post-intervention to 4 weeks)
SMD -0.40 [-1.14, 0.33]9 studiesGRADE not reported
Pain intensity
Photobiomodulation / low-level laser therapy (PBM/LLLT) vs Inactive control (placebo, sham, usual care or no intervention) · Short-term (immediate to 4 weeks)
SMD -0.42 [-0.61, -0.23]10 studies · 462 participantsGRADE not reported

The review does not say which of its outcomes this study informs.

2 including reviews in total.