Non-Cochrane · intervention · PM42151053
Comparison of the cyclic fatigue resistance of original and replica-like files: a systematic review and meta-analysis.
Unal Mert, Cakici Fatih · Restorative dentistry & endodontics · 2026 · PubMed · doi:10.5395/rde.2026.51.e25
Findings
14 findings
| Population | ||||
|---|---|---|---|---|
| Ni-Ti endodontic files tested for cyclic fatigue in artificial canals (in vitro) | Replica-like Ni-Ti endodontic files | Original-brand Ni-Ti endodontic files | Time to fracture (TTF), cyclic fatigue resistance Laboratory, artificial root canal · Overall (temperature subgroup model, 51 comparison data sets) | SMD -1.197 [-1.830, -0.564] GRADE not reported Studies not reported |
| Ni-Ti endodontic files tested for cyclic fatigue in artificial canals (in vitro) | Replica-like Ni-Ti endodontic files | Original-brand Ni-Ti endodontic files | Number of cycles to fracture (NCF), cyclic fatigue resistance Laboratory, artificial root canal · Overall (temperature subgroup model, 9 comparison data sets) | SMD -1.719 [-4.270, 0.833] GRADE not reported Studies not reported |
| Ni-Ti endodontic files tested for cyclic fatigue in artificial canals (in vitro) | Replica-like Ni-Ti endodontic files | Original-brand Ni-Ti endodontic files | Time to fracture (TTF), cyclic fatigue resistance Laboratory, artificial root canal · Overall (kinematics subgroup model) | SMD -0.579 [-3.021, 1.862] GRADE not reported Studies not reported |
| Ni-Ti endodontic files tested for cyclic fatigue in artificial canals (in vitro) | Replica-like Ni-Ti endodontic files | Original-brand Ni-Ti endodontic files | Time to fracture (TTF), cyclic fatigue resistance Laboratory, artificial root canal | SMD -0.845 [-1.268, -0.423] GRADE not reported 13 studies |
| Ni-Ti endodontic files tested for cyclic fatigue in artificial canals (in vitro) | Replica-like Ni-Ti endodontic files | Original-brand Ni-Ti endodontic files | Number of cycles to fracture (NCF), cyclic fatigue resistance Laboratory, artificial root canal | SMD -1.532 [-3.615, 0.550] GRADE not reported 5 studies |
| Ni-Ti endodontic files tested for cyclic fatigue in artificial canals (in vitro) | Replica-like Ni-Ti endodontic files | Original-brand Ni-Ti endodontic files | Number of cycles to fracture (NCF), cyclic fatigue resistance Laboratory, artificial root canal · Overall (kinematics subgroup model) | SMD -1.395 [-4.075, 1.286] GRADE not reported Studies not reported |
| Ni-Ti endodontic files tested for cyclic fatigue in artificial canals (in vitro), rotary files | Replica-like Ni-Ti endodontic files | Original-brand Ni-Ti endodontic files | Number of cycles to fracture (NCF), cyclic fatigue resistance Laboratory, artificial root canal · Kinematics: rotary files | SMD -2.178 [-4.618, 0.262] GRADE not reported Studies not reported |
| Ni-Ti endodontic files tested for cyclic fatigue in artificial canals (in vitro), rotary files | Replica-like Ni-Ti endodontic files | Original-brand Ni-Ti endodontic files | Time to fracture (TTF), cyclic fatigue resistance Laboratory, artificial root canal · Kinematics: rotary files | SMD -1.819 [-2.331, -1.306] GRADE not reported Studies not reported |
| Ni-Ti endodontic files tested for cyclic fatigue in artificial canals (in vitro), reciprocating files | Replica-like Ni-Ti endodontic files | Original-brand Ni-Ti endodontic files | Time to fracture (TTF), cyclic fatigue resistance Laboratory, artificial root canal · Kinematics: reciprocating files | SMD 0.673 [0.052, 1.293] GRADE not reported Studies not reported |
| Ni-Ti endodontic files tested for cyclic fatigue in artificial canals (in vitro), reciprocating files | Replica-like Ni-Ti endodontic files | Original-brand Ni-Ti endodontic files | Number of cycles to fracture (NCF), cyclic fatigue resistance Laboratory, artificial root canal · Kinematics: reciprocating files | SMD 0.993 [-4.056, 6.042] GRADE not reported Studies not reported |
| Ni-Ti endodontic files tested for cyclic fatigue in artificial canals (in vitro), tested at room temperature | Replica-like Ni-Ti endodontic files | Original-brand Ni-Ti endodontic files | Number of cycles to fracture (NCF), cyclic fatigue resistance Laboratory, artificial root canal · Test temperature: room temperature | SMD -0.620 [-3.926, 2.685] GRADE not reported Studies not reported |
| Ni-Ti endodontic files tested for cyclic fatigue in artificial canals (in vitro), tested at room temperature | Replica-like Ni-Ti endodontic files | Original-brand Ni-Ti endodontic files | Time to fracture (TTF), cyclic fatigue resistance Laboratory, artificial root canal · Test temperature: room temperature | SMD -1.404 [-2.145, -0.664] GRADE not reported Studies not reported |
| Ni-Ti endodontic files tested for cyclic fatigue in artificial canals (in vitro), tested at body temperature | Replica-like Ni-Ti endodontic files | Original-brand Ni-Ti endodontic files | Number of cycles to fracture (NCF), cyclic fatigue resistance Laboratory, artificial root canal · Test temperature: body temperature | SMD -3.339 [-7.353, 0.675] GRADE not reported Studies not reported |
| Ni-Ti endodontic files tested for cyclic fatigue in artificial canals (in vitro), tested at body temperature | Replica-like Ni-Ti endodontic files | Original-brand Ni-Ti endodontic files | Time to fracture (TTF), cyclic fatigue resistance Laboratory, artificial root canal · Test temperature: body temperature | SMD -0.631 [-1.853, 0.592] GRADE not reported Studies not reported |
Included primary studies 14
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Alcalde 2020 Mechanical Properties of ProTaper Gold, EdgeTaper Platinum, Flex Gold and Pro-T Rotary Systems. PMID:33353917 | 2020 | 1 other review | Time to fracture (TTF), cyclic fatigue resistance; Number of cycles to fracture (NCF), cyclic fatigue resistance | not extracted yet |
| Martins 2022 Design, Metallurgical Features, and Mechanical Behaviour of NiTi Endodontic Instruments from Five Different Heat-Treated Rotary Systems. PMID:35160955 | 2022 | 1 other review | Time to fracture (TTF), cyclic fatigue resistance | not extracted yet |
| Alnoury 2024 Cyclic fatigue resistance of ProTaper gold and two replicalike rotary systems. An in vitro study DOI:10.4103/sej.sej_89_23 | 2024 | this review only | Time to fracture (TTF), cyclic fatigue resistance; Number of cycles to fracture (NCF), cyclic fatigue resistance | not extracted yet |
| Aydin 2024 Evaluation of Cyclic Fatigue Resistance of Novel Replica-Like Instruments in Static Test Model. PMID:39206445 | 2024 | this review only | Number of cycles to fracture (NCF), cyclic fatigue resistance | not extracted yet |
| Lima 2024 Cyclic and torsional fatigue resistance of two replicalike and original brand reciprocating system DOI:10.21726/rsbo.v21i2.2511 | 2024 | this review only | Time to fracture (TTF), cyclic fatigue resistance; Number of cycles to fracture (NCF), cyclic fatigue resistance | not extracted yet |
| Martins 2020a Mechanical Performance and Metallurgical Features of ProTaper Universal and 6 Replicalike Systems. PMID:32898557 | 2020 | this review only | Time to fracture (TTF), cyclic fatigue resistance | not extracted yet |
| Martins 2020b Influence of Kinematics on the Cyclic Fatigue Resistance of Replicalike and Original Brand Rotary Instruments. PMID:32413441 | 2020 | this review only | Time to fracture (TTF), cyclic fatigue resistance | not extracted yet |
| Martins 2021a Comparison of design, metallurgy, mechanical performance and shaping ability of replica-like and counterfeit instruments of the ProTaper… PMID:33300121 | 2021 | this review only | Time to fracture (TTF), cyclic fatigue resistance | not extracted yet |
| Martins 2021b Design, metallurgical features, mechanical performance and canal preparation of six reciprocating instruments. PMID:33829516 | 2021 | this review only | Time to fracture (TTF), cyclic fatigue resistance | not extracted yet |
| Rios-Osorio 2025 Dynamic cyclic fatigue resistance of Reciproc® Blue, One Reci®, R-Motion®, and two Replica-Like endodontic files after autoclave… PMID:40485975 | 2025 | this review only | Time to fracture (TTF), cyclic fatigue resistance | not extracted yet |
| Tarrago 2025 Cyclic Fatigue Resistance of 'Replica-Like" and Original Reciprocating Instruments in Single and Double Curvatures. PMID:40464535 | 2025 | this review only | Time to fracture (TTF), cyclic fatigue resistance | not extracted yet |
| Unal 2026 Comparison of Design, Cyclic Fatigue Resistance, and Metallurgical Properties of Original, Replica-Like, and Counterfeit Nickel-Titanium… PMID:40794724 | 2026 | this review only | Time to fracture (TTF), cyclic fatigue resistance | not extracted yet |
| Uslu 2023 Comparison of mechanical resistance and standardisation between original brand and replica-like endodontic systems. PMID:35703893 | 2023 | this review only | Time to fracture (TTF), cyclic fatigue resistance | not extracted yet |
| Zanza 2022 Mechanical and Metallurgical Evaluation of 3 Different Nickel-Titanium Rotary Instruments: An In Vitro and In Laboratory Study. PMID:35621499 | 2022 | this review only | Time to fracture (TTF), cyclic fatigue resistance; Number of cycles to fracture (NCF), cyclic fatigue resistance | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Comparative Evaluation of Cyclic Fatigue Resistance of EdgeTaper Platinum and ProTaper Gold Rotary Instruments: A Systematic Review and… (2026) | 2 | 0.11 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Ni-Ti endodontic instruments | 1,276 Ni-Ti endodontic files: nine original and 31 replica-like types (14 studies) |
| Intervention | Instrumentation of the Ni-Ti files within artificial root canals (replica-like files) | Replica-like files (rotary systems in 8 studies, Reciproc-type in 5, both in 1) |
| Comparison | Original files versus replica-like files | Original brand files |
| Outcomes | Cyclic fatigue resistance (time to fracture, number of cycles to fracture) | Time to fracture (13 studies, 59 comparisons); number of cycles to fracture (5 studies, 11 comparisons) |
| Study designs | Laboratory (in vitro) studies comparing original and replica-like files in the same setup with a standardized device | In vitro laboratory studies (static model in 12, dynamic in 2) |
| Timing | Published up to July 6, 2025; English | Not specified |