Non-Cochrane · intervention · PM41965616
The effect of non-invasive physical interventions for accelerating tooth movement on orthodontically induced inflammatory root resorption: a systematic review and network meta-analysis.
Li Junxiong, Li Yanjie, Xu Xiaoxia, et al. · BMC oral health · 2026 · PubMed · doi:10.1186/s12903-026-08301-x
Findings
15 findings
| Population | ||||
|---|---|---|---|---|
| Patients undergoing first orthodontic treatment | Low-level laser therapy (LLLT) | Control or placebo (conventional orthodontic treatment) | Orthodontically induced inflammatory root resorption (OIIRR) After orthodontic force application (time point varies by study) · Orthodontic patients | SMD -0.31 [-0.77, 0.14] Very low Downgraded: risk of bias, inconsistency 7 studies · 240 participants |
| Patients undergoing first orthodontic treatment | Low-level laser therapy (LLLT) | Control or placebo (conventional orthodontic treatment) | Orthodontically induced inflammatory root resorption (OIIRR) After orthodontic force application (time point varies by study) · Orthodontic patients · Measurement unit: volume (mm3) | SMD -0.49 [-1.17, 0.18] GRADE not reported 4 studies · 144 participants |
| Patients undergoing first orthodontic treatment | Low-level laser therapy (LLLT) | Control or placebo (conventional orthodontic treatment) | Orthodontically induced inflammatory root resorption (OIIRR) After orthodontic force application (time point varies by study) · Orthodontic patients · Measurement unit: length (mm) | SMD -0.01 [-0.42, 0.41] GRADE not reported 3 studies · 96 participants |
| Patients undergoing first-time orthodontic treatment | LLLT (low-level laser therapy) | Control or placebo (conventional orthodontic treatment) | OIIRR ranking in the network meta-analysis (SUCRA) Predefined measurement time point after start of orthodontic treatment | SUCRA 48.7 GRADE not reported Studies not reported |
| Patients undergoing first orthodontic treatment | Light-emitting diode (LED) therapy | Control or placebo (conventional orthodontic treatment) | Orthodontically induced inflammatory root resorption (OIIRR) After orthodontic force application (time point varies by study) · Orthodontic patients | MD -0.14 [-0.18, -0.10] Very low Downgraded: risk of bias, inconsistency 2 studies · 60 participants |
| Patients undergoing first-time orthodontic treatment | LED (light-emitting diode) therapy | Control or placebo (conventional orthodontic treatment) | OIIRR ranking in the network meta-analysis (SUCRA) Predefined measurement time point after start of orthodontic treatment | SUCRA 75.9 GRADE not reported Studies not reported |
| Patients undergoing first orthodontic treatment | Vibration (mechanical vibration or low-intensity pulsed ultrasound) | Control or sham (conventional orthodontic treatment) | Orthodontically induced inflammatory root resorption (OIIRR) After orthodontic force application (time point varies by study) · Orthodontic patients · Measurement unit: length (mm) | SMD -0.29 [-0.82, 0.23] GRADE not reported 2 studies · 75 participants |
| Patients undergoing first-time orthodontic treatment | Vibration | Control or sham (conventional orthodontic treatment) | OIIRR ranking in the network meta-analysis (SUCRA) Predefined measurement time point after start of orthodontic treatment | SUCRA 63.7 GRADE not reported Studies not reported |
| Patients undergoing first orthodontic treatment | Vibration (mechanical vibration or low-intensity pulsed ultrasound) | Control or sham (conventional orthodontic treatment) | Orthodontically induced inflammatory root resorption (OIIRR) After orthodontic force application (time point varies by study) · Orthodontic patients | SMD -1.67 [-3.54, 0.20] Very low Downgraded: risk of bias, inconsistency 4 studies · 135 participants |
| Patients undergoing first orthodontic treatment | Vibration (mechanical vibration or low-intensity pulsed ultrasound) | Control or sham (conventional orthodontic treatment) | Orthodontically induced inflammatory root resorption (OIIRR) After orthodontic force application (time point varies by study) · Orthodontic patients · Measurement unit: volume (mm3) | SMD -3.30 [-9.93, 3.33] GRADE not reported 2 studies · 60 participants |
| Patients undergoing first orthodontic treatment | LED therapy | LLLT | Orthodontically induced inflammatory root resorption (OIIRR) After orthodontic force application (time point varies by study) · Orthodontic patients · Indirect (network) comparison | Indirect evidence from the network meta-analysis; numeric network estimate not reported Low Downgraded: risk of bias, inconsistency Studies not reported |
| Patients undergoing first orthodontic treatment | LED therapy | Vibration | Orthodontically induced inflammatory root resorption (OIIRR) After orthodontic force application (time point varies by study) · Orthodontic patients · Indirect (network) comparison | Indirect evidence from the network meta-analysis; numeric network estimate not reported Low Downgraded: risk of bias, inconsistency Studies not reported |
| Patients undergoing first orthodontic treatment | LLLT | Vibration | Orthodontically induced inflammatory root resorption (OIIRR) After orthodontic force application (time point varies by study) · Orthodontic patients · Indirect (network) comparison | Indirect evidence from the network meta-analysis; numeric network estimate not reported Low Downgraded: risk of bias, inconsistency Studies not reported |
| Patients undergoing first-time orthodontic treatment | Control (conventional orthodontic treatment) | Active physical interventions (LLLT, LED, vibration) | OIIRR ranking in the network meta-analysis (SUCRA) Predefined measurement time point after start of orthodontic treatment | SUCRA 11.7 GRADE not reported Studies not reported |
| Patients undergoing first-time orthodontic treatment | Physical interventions combined (LLLT, LED, vibration) | Control | Orthodontically induced inflammatory root resorption (OIIRR) Predefined measurement time point after start of orthodontic treatment Unresolved: the two extractors disagree on this row. | -0.85 [-1.42, -0.28] GRADE not reported 12 studies |
Included primary studies 20
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Okla 2018 Effect of Photobiomodulation on Maxillary Decrowding and Root Resorption: A Randomized Clinical Trial DOI:10.4103/apos.apos_46_18 | 2018 | 2 other reviews | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Ang Khaw 2018 Physical properties of root cementum: Part 27. Effect of low-level laser therapy on the repair of orthodontically induced inflammatory… DOI:10.1016/j.ajodo.2018.04.022 | 2018 | 1 other review | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| DiBiase 2016 Effect of supplemental vibrational force on orthodontically induced inflammatory root resorption: A multicenter randomized clinical trial DOI:10.1016/j.ajodo.2016.06.025 | 2016 | 1 other review | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| El-Bialy 2020 Effect of Low Intensity Pulsed Ultrasound (LIPUS) on Tooth Movement and Root Resorption: A Prospective Multi-Center Randomized Controlled… PMID:32188053 | 2020 | 1 other review | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Goymen 2020 Effect of photobiomodulation therapies on the root resorption associated with orthodontic forces: a pilot study using micro computed… DOI:10.1007/s00784-019-03155-w | 2019 | 1 other review | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Joseph 2022 Comparison of Rate of Tooth Movement, Root Resorption and Pulp Vitality during En masse Anterior Retraction with Micro-osteoperforation… DOI:10.7860/jcdr/2022/55298.16802 | 2022 | 1 other review | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Nayyer 2021 Effect of photobiomodulation on external root resorption during orthodontic tooth movement – a randomized controlled trial DOI:10.1016/j.ortho.2021.01.007 | 2021 | 1 other review | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Ng 2018 The effect of low-level laser therapy on orthodontically induced root resorption: a pilot double blind randomized controlled trial DOI:10.1093/ejo/cjx065 | 2017 | 1 other review | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Raza 2016 Effect of low-intensity pulsed ultrasound on orthodontically induced root resorption caused by torque: A prospective, double-blind,… DOI:10.2319/081915-554.1 | 2016 | 1 other review | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Sambevski 2022 Physical properties of root cementum: Part 29. The effects of LED-mediated photobiomodulation on orthodontically induced root resorption… DOI:10.1093/ejo/cjac022 | 2022 | 1 other review | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Ang Khaw 2018 Physical properties of root cementum: Part 27. Effect of low-level laser therapy on the repair of orthodontically induced inflammatory… PMID:30173835 | 2018 | this review only | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| DiBiase 2016 Effect of supplemental vibrational force on orthodontically induced inflammatory root resorption: A multicenter randomized clinical trial. PMID:27894540 | 2016 | this review only | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Goymen 2020 Effect of photobiomodulation therapies on the root resorption associated with orthodontic forces: a pilot study using micro computed… PMID:31773372 | 2020 | this review only | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Hasan 2020 The Effect Of Low-Level Laser Therapy On The Rate Of Tooth Movement During Maxillary Canine Retraction: A Randomized Clinical Trial DOI:10.21608/asdj.2021.59455.1014 | 2021 | this review only | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Nayyer 2021 Effect of photobiomodulation on external root resorption during orthodontic tooth movement - a randomized controlled trial. PMID:33610485 | 2021 | this review only | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Ng 2018 The effect of low-level laser therapy on orthodontically induced root resorption: a pilot double blind randomized controlled trial. PMID:29016741 | 2018 | this review only | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Raza 2016 Effect of low-intensity pulsed ultrasound on orthodontically induced root resorption caused by torque: A prospective, double-blind,… PMID:26624250 | 2016 | this review only | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Sambevski 2022 Physical properties of root cementum: Part 29. The effects of LED-mediated photobiomodulation on orthodontically induced root resorption… PMID:35552386 | 2022 | this review only | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Yilmaz 2021 The effect of 12 weeks of mechanical vibration on root resorption: a micro-CT study DOI:10.1186/s40510-021-00369-1 | 2021 | this review only | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
| Yilmaz 2021 The effect of 12 weeks of mechanical vibration on root resorption: a micro-CT study. PMID:34423388 | 2021 | this review only | Orthodontically induced inflammatory root resorption (OIIRR) | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients undergoing first-time orthodontic treatment | Orthodontic patients (n=240 LLLT, 60 LED, 135 vibration participants in pooled analyses) |
| Intervention | Non-invasive physical interventions: LLLT, LED therapy, vibration | LLLT (n=7 studies), LED (n=2), vibration (n=4) |
| Comparison | Conventional orthodontic treatment without adjunctive physical intervention | Control or placebo or sham |
| Outcomes | Extent of OIIRR | OIIRR (volume mm3 or length mm) |
| Study designs | RCTs | RCTs (n=12) |
| Timing | From start of orthodontic treatment to predefined measurement time point | Not specified |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Partial Yes | Partial Yes | yes |
| 3Choice of study designs explained | Yes | Yes | yes |
| 4Comprehensive literature searchcritical | No | Partial Yes | no |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | No | No | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Partial Yes | Yes | no |
| 9Risk of bias assessed satisfactorilycritical | RCT: Yes · NRSI: N/A | NRSI: N/A · RCT: Yes | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: Yes · NRSI: N/A | NRSI: N/A · RCT: Yes | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | Yes | Yes | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Low | no |