Non-Cochrane · intervention · PM42054790
Effect of Micro-Osteoperforations on Orthodontic Tooth Movement: A Systematic Review and Meta-Analysis.
Heidari Ali, Mojiri Sepideh, Azarbayjani Masood, et al. · International dental journal · 2026 · PubMed · doi:10.1016/j.identj.2026.109536
Findings
198 findings
| Population | ||||
|---|---|---|---|---|
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Study design and total perforations: <=3 in split-mouth studies | SMD 0.67 [0.19, 1.14] GRADE not reported 10 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Study design and total perforations: >3 in split-mouth studies | SMD 2.21 [0.77, 3.64] GRADE not reported 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Attachment loss | MD -0.26 [-0.86, 0.33] Very low Downgraded: imprecision, inconsistency 6 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · OTM measurement: Digital caliper | SMD 2.43 [1.70, 3.16] GRADE not reported 16 studies |
| Human orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) of the alveolar cortical bone with fixed-appliance mechanics | Identical fixed-appliance mechanics without MOPs | Orthodontic tooth movement, baseline to 4 weeks Baseline to 4 weeks · Orthodontic treatment with fixed appliances · Depth and jaw: less than 5 mm in maxilla and mandible | SMD 2.36 [1.44, 3.29] GRADE not reported 4 studies |
| Human orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) of the alveolar cortical bone with fixed-appliance mechanics | Identical fixed-appliance mechanics without MOPs | Orthodontic tooth movement, baseline to 4 weeks Baseline to 4 weeks · Orthodontic treatment with fixed appliances · Type of bracket: group without a label in the forest plot | SMD 2.59 [1.54, 3.64] GRADE not reported 3 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Perforation on palatal side: No | SMD 1.60 [1.10, 2.10] GRADE not reported 26 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Immediate postoperative pain (VAS) Immediately after the procedure · Jaw: Mandible | MD 2.05 [-1.44, 5.54] GRADE not reported 3 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Immediate postoperative pain (VAS) Immediately after the procedure · Meta-regression: total number of perforations | Meta-regression coefficient 0.463 [0.249, 0.677] GRADE not reported 8 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Working wire dimension: 0.016 x 0.022 | SMD 1.03 [0.58, 1.47] GRADE not reported 2 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Measured distance: TAD or appliance reference (C-TAD/Appliance) | MD 0.29 [-0.12, 0.70] Low Downgraded: imprecision, inconsistency 2 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Type of OTM: Alignment | SMD 1.58 [0.64, 2.51] GRADE not reported 8 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Alqadasi et al., 2024 | SMD 1.703 [1.234, 2.172] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Pain change from baseline (VAS) 24 hours | MD -0.13 [-0.63, 0.36] Low Downgraded: risk of bias, imprecision 7 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Alqadasi et al., 2024 | SMD 1.616 [1.147, 2.086] GRADE not reported 29 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Root resorption (mm) | MD 0.01 [-0.04, 0.07] Moderate Downgraded: imprecision 6 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Venkatachalapathy et al., 2022 | SMD 1.601 [1.093, 2.109] GRADE not reported 24 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Risk of bias subgroup, Selective reporting (RoB 1): Unclear risk | SMD 2.35 [1.45, 3.26] GRADE not reported 12 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting GOWDA S V et al., 2019 | SMD 1.632 [1.160, 2.105] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Alfailany et al., 2023 | SMD 1.669 [1.162, 2.176] GRADE not reported 25 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Depth and total perforations: >=5 mm and <=3 | SMD 0.27 [-0.01, 0.56] GRADE not reported 6 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Jaw and type of OTM: Maxillary and mandibular canine retraction | SMD 1.91 [1.27, 2.55] GRADE not reported 3 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Sensitivity: available change SDs | SMD 1.82 [1.29, 2.35] GRADE not reported 24 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Fattori et al., 2020 | SMD 2.004 [1.174, 2.834] GRADE not reported 14 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Risk of bias subgroup, Random sequence generation (RoB 1): Unclear risk | SMD 2.07 [1.16, 2.99] GRADE not reported 7 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Aboalga et al., 2019 | SMD 3.129 [1.604, 4.654] GRADE not reported 7 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Immediate postoperative pain (VAS) Immediately after the procedure · Palatal perforation: No | MD 1.14 [-0.39, 2.67] GRADE not reported 6 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Jaw, total perforations and depth: >3, <5 mm in maxilla | SMD 1.39 [0.17, 2.61] GRADE not reported 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Depth and instrument: >=5 mm with miniscrew/mini-implant | SMD 0.75 [-0.19, 1.70] GRADE not reported 6 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Perforation depth: <5 mm | SMD 1.77 [1.25, 2.29] GRADE not reported 19 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Sensitivity: calculated average across parts of tooth | SMD 3.84 [1.93, 5.75] GRADE not reported 6 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Total perforations and jaw: >3 in mandible | SMD 2.07 [0.93, 3.21] GRADE not reported 6 studies |
| Human orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) of the alveolar cortical bone with fixed-appliance mechanics | Identical fixed-appliance mechanics without MOPs | Orthodontic tooth movement, baseline to 4 weeks Baseline to 4 weeks · Orthodontic treatment with fixed appliances · Type of bracket: MBT | SMD 1.69 [1.01, 2.37] GRADE not reported 14 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Kilinc and Baka, 2023 | SMD 1.689 [1.214, 2.163] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Aboalga et al., 2019 | SMD 1.697 [1.223, 2.171] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Gingival index | SMD 0.06 [-0.79, 0.91] Low Downgraded: imprecision, inconsistency 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Ahsan et al., 2021 | SMD 1.756 [1.074, 2.437] GRADE not reported 17 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to last follow-up (3 weeks to 10 months) · Repeat of MOP: No | SMD 1.73 [1.28, 2.17] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Attri et al., 2018 | SMD 1.649 [1.171, 2.127] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Risk of bias subgroup, Selective reporting (RoB 1): Low risk | SMD 1.36 [0.84, 1.88] GRADE not reported 18 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Gulduren et al., 2020 | SMD 1.856 [1.070, 2.643] GRADE not reported 15 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Depth and instrument: >=5 mm with Propel | SMD 0.58 [-0.23, 1.39] GRADE not reported 2 studies |
| Human orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) of the alveolar cortical bone with fixed-appliance mechanics | Identical fixed-appliance mechanics without MOPs | Orthodontic tooth movement, baseline to 4 weeks Baseline to 4 weeks · Orthodontic treatment with fixed appliances · Jaw: mandible | SMD 2.07 [0.93, 3.21] GRADE not reported 6 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Jaw, total perforations and depth: >3, >=5 mm in mandible | SMD 2.43 [-0.38, 5.24] GRADE not reported 2 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Alqadasi et al., 2019 | SMD 1.701 [1.232, 2.170] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Jaw, total perforations and depth: >3, <5 mm in mandible | SMD 2.26 [0.36, 4.16] GRADE not reported 3 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting El Awady et al., 2019 | SMD 1.679 [1.204, 2.154] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Pain change from baseline (VAS) 24 hours | SMD -0.15 [-0.44, 0.14] Low Downgraded: risk of bias, imprecision 7 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · WHO region: EMRO | SMD 2.10 [1.16, 3.04] GRADE not reported 11 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Meta-regression: distance between perforations (mm) | Meta-regression coefficient -0.431 [-1.100, 0.239] GRADE not reported 11 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Risk of bias subgroup, Blinding of outcome assessment (RoB 1): Unclear risk | SMD 1.27 [0.64, 1.89] GRADE not reported 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Golshah et al., 2021 | SMD 1.652 [1.016, 2.289] GRADE not reported 18 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Malocclusion: Class I only | SMD 2.12 [0.74, 3.50] GRADE not reported 3 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Measured distance: model-based custom references (C-Model) | SMD 0.63 [0.10, 1.16] Low Downgraded: inconsistency 8 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Total perforations and jaw: <=3 in maxilla | SMD 1.58 [0.88, 2.27] GRADE not reported 15 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Measured distance: TAD or appliance reference (C-TAD/Appliance) | SMD 0.65 [-0.40, 1.70] Very low Downgraded: imprecision, inconsistency 2 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Ozkan et al., 2021 | SMD 1.659 [1.185, 2.133] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · WHO region: PAHO | SMD 2.41 [-0.17, 4.99] GRADE not reported 3 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Study design and total perforations: >3 in parallel-arm studies | SMD 1.76 [0.83, 2.68] GRADE not reported 9 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Sensitivity: calculated average across perforation numbers | SMD 2.44 [-0.32, 5.21] GRADE not reported 2 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Kilinc and Baka, 2023 | SMD 1.616 [1.128, 2.105] GRADE not reported 26 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · WHO region: WPRO | SMD 0.05 [-0.40, 0.51] GRADE not reported 3 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Type of OTM: Canine retraction | SMD 1.75 [1.20, 2.31] GRADE not reported 22 studies |
| Human orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) of the alveolar cortical bone with fixed-appliance mechanics | Identical fixed-appliance mechanics without MOPs | Orthodontic tooth movement, baseline to 4 weeks Baseline to 4 weeks · Orthodontic treatment with fixed appliances · Leave-one-out sensitivity analysis: omitting Mordente et al., 2024 | SMD 1.700 [1.228, 2.173] GRADE not reported 30 studies |
| Human orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) of the alveolar cortical bone with fixed-appliance mechanics | Identical fixed-appliance mechanics without MOPs | Orthodontic tooth movement, baseline to 4 weeks Baseline to 4 weeks · Orthodontic treatment with fixed appliances · Risk of bias, incomplete outcome data: low risk | SMD 1.68 [1.20, 2.15] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Immediate postoperative pain (VAS) Immediately after the procedure · Meta-regression: female percentage | Meta-regression coefficient -0.039 [-0.157, 0.079] GRADE not reported 7 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Ozkan et al., 2021 | SMD 1.624 [1.018, 2.231] GRADE not reported 19 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Probing pocket depth | MD 0.19 [-0.63, 1.00] Very low Downgraded: imprecision, inconsistency 3 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Measured distance: extraction space (EXT) | SMD 1.96 [0.08, 3.84] Low Downgraded: inconsistency 3 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to GOWDA S V et al., 2019 | SMD 2.218 [1.265, 3.171] GRADE not reported 12 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Gingival index | MD 0.03 [-0.30, 0.37] Low Downgraded: imprecision, inconsistency 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Immediate postoperative pain (VAS) Immediately after the procedure · Study design: Parallel arms | MD 1.65 [-1.08, 4.37] GRADE not reported 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Study design and total perforations: <=3 in parallel-arm studies | SMD 3.05 [1.71, 4.39] GRADE not reported 8 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Al-Attar et al., 2022 | SMD 1.664 [1.101, 2.227] GRADE not reported 21 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Instrument for MOP: Propel | SMD 2.97 [1.44, 4.49] GRADE not reported 7 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to RAGHAV et al., 2020 | SMD 1.736 [1.021, 2.451] GRADE not reported 16 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · WHO region: SEARO | SMD 2.07 [1.42, 2.71] GRADE not reported 10 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Working wire dimension: 0.017 x 0.025 | SMD 1.04 [0.12, 1.97] GRADE not reported 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Al-Attar et al., 2022 | SMD 1.585 [1.124, 2.046] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Immediate postoperative pain (VAS) Immediately after the procedure · Palatal perforation: Yes | MD 0.63 [0.19, 1.06] GRADE not reported 2 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Gulduren et al., 2020 | SMD 1.700 [1.230, 2.170] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Risk of bias subgroup, Blinding of outcome assessment (RoB 1): Low risk | SMD 1.41 [0.95, 1.86] GRADE not reported 25 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Perforation on palatal side: Yes | SMD 1.87 [0.56, 3.19] GRADE not reported 5 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Sensitivity: calculated change SDs (r=0.5) | SMD 1.07 [0.09, 2.04] GRADE not reported 7 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Total perforations and jaw: >3 in maxilla | SMD 1.13 [0.09, 2.16] GRADE not reported 5 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Depth and total perforations: <5 mm and <=3 | SMD 1.44 [0.83, 2.05] GRADE not reported 10 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Measured distance: canine to second premolar (C2P) | SMD 1.05 [0.43, 1.66] Very low Downgraded: risk of bias, inconsistency 7 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Venkatachalapathy et al., 2022 | SMD 1.605 [1.140, 2.070] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Measured distance: canine to lateral incisor (CL) | SMD 4.94 [3.09, 6.79] Very low Downgraded: risk of bias, inconsistency 6 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Ahsan et al., 2021 | SMD 1.626 [1.155, 2.098] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Risk of bias subgroup, Allocation concealment (RoB 1): Low risk | SMD 1.47 [0.85, 2.09] GRADE not reported 19 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · WHO region: EURO | SMD 0.73 [0.21, 1.26] GRADE not reported 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Pain change from baseline (VAS) 7 days | MD 0.79 [-5.28, 6.85] Very low Downgraded: risk of bias, imprecision, inconsistency 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to last follow-up (3 weeks to 10 months) · Meta-regression: number of MOP repeats | Meta-regression coefficient 0.536 [0.042, 1.031] GRADE not reported 6 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Immediate postoperative pain (VAS) Immediately after the procedure · Instrument: Miniscrew/mini-implant | MD 0.57 [0.11, 1.04] GRADE not reported 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Alikhani et al., 2013 | SMD 1.521 [1.075, 1.966] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Measured distance: canine to lateral incisor (CL) | MD 0.65 [0.38, 0.93] Very low Downgraded: risk of bias, inconsistency 6 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Kundi et al., 2018 | SMD 1.402 [1.002, 1.803] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Alfailany et al., 2023 | SMD 1.588 [1.127, 2.050] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Immediate postoperative pain (VAS) Immediately after the procedure · Meta-regression: mean age (years) | Meta-regression coefficient -0.186 [-0.369, -0.003] GRADE not reported 8 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Malocclusion: Other | SMD 1.05 [0.10, 2.00] GRADE not reported 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Immediate postoperative pain (VAS) Immediately after the procedure · Jaw: Maxilla | MD 0.14 [-0.59, 0.87] GRADE not reported 5 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Thomas et al., 2021 | SMD 1.675 [1.192, 2.158] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Jaw, total perforations and depth: >3, <5 mm in maxilla and mandible | SMD 3.47 [1.68, 5.25] GRADE not reported 2 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Study design: Parallel arms | SMD 2.27 [1.50, 3.04] GRADE not reported 17 studies |
| Human orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) of the alveolar cortical bone with fixed-appliance mechanics | Identical fixed-appliance mechanics without MOPs | Orthodontic tooth movement, baseline to 4 weeks Baseline to 4 weeks · Orthodontic treatment with fixed appliances · Jaw and type of tooth movement: mandibular alignment | SMD 1.71 [0.64, 2.78] GRADE not reported 5 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Measured distance: Little's Irregularity Index (LII) | MD 1.24 [1.06, 1.43] High 5 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to last follow-up (3 weeks to 10 months) · Meta-regression: study duration (weeks), MOP not repeated | Meta-regression coefficient -0.170 [-0.250, -0.087] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Golshah et al., 2021 | SMD 1.697 [1.220, 2.174] GRADE not reported 30 studies |
| Human orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) of the alveolar cortical bone with fixed-appliance mechanics | Identical fixed-appliance mechanics without MOPs | Orthodontic tooth movement, baseline to 4 weeks Baseline to 4 weeks · Orthodontic treatment with fixed appliances · Publication bias: Egger regression test Unresolved: the two extractors disagree on this row. | Egger test intercept 8.91 GRADE not reported Studies not reported |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Perforation depth: >=5 mm | SMD 0.63 [0.00, 1.26] GRADE not reported 9 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to last follow-up (3 weeks to 10 months) · Meta-regression: study duration (weeks), MOP repeated | Meta-regression coefficient -0.137 [-0.250, -0.024] GRADE not reported 9 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Depth and total perforations: >=5 mm and >3 | SMD 1.63 [-0.41, 3.67] GRADE not reported 3 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to last follow-up (3 weeks to 10 months) · Meta-regression: study duration (weeks), all studies | Meta-regression coefficient -0.168 [-0.228, -0.096] GRADE not reported 39 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Sensitivity: any calculated average or pooled SD | SMD 2.96 [1.97, 3.94] GRADE not reported 12 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Jaw, total perforations and depth: <=3, <5 mm in maxilla | SMD 1.45 [0.68, 2.21] GRADE not reported 8 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Malocclusion: Class II only | SMD 3.06 [1.33, 4.80] GRADE not reported 7 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Meta-regression: perforation diameter (mm) | Meta-regression coefficient -2.762 [-5.185, 0.338] GRADE not reported 27 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Immediate postoperative pain (VAS) Immediately after the procedure | SMD 0.37 [-0.35, 1.08] Very low Downgraded: risk of bias, imprecision, inconsistency 8 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Rashid et al., 2018 | SMD 1.661 [1.188, 2.135] GRADE not reported 30 studies |
| Human orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) of the alveolar cortical bone with fixed-appliance mechanics | Identical fixed-appliance mechanics without MOPs | Orthodontic tooth movement, baseline to 4 weeks Baseline to 4 weeks · Orthodontic treatment with fixed appliances · Type of bracket: Roth | SMD 0.51 [0.17, 0.85] GRADE not reported 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Depth and jaw: <5 mm in mandible | SMD 2.26 [0.36, 4.16] GRADE not reported 3 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Female proportion: >60% | SMD 1.30 [0.55, 2.05] GRADE not reported 9 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Al-Hayek et al., 2019 | SMD 1.675 [1.201, 2.149] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Alkebsi et al., 2018 | SMD 1.706 [1.238, 2.174] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Li et al., 2022 | SMD 1.585 [1.044, 2.127] GRADE not reported 22 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Depth and instrument: <5 mm with miniscrew/mini-implant | SMD 1.78 [1.22, 2.33] GRADE not reported 15 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Malocclusion: Mixed/multiple | SMD 1.21 [0.64, 1.78] GRADE not reported 11 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Jaw: Maxilla | SMD 1.43 [0.86, 2.00] GRADE not reported 20 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Singh et al., 2023 | SMD 1.559 [1.106, 2.012] GRADE not reported 30 studies |
| Human orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) of the alveolar cortical bone with fixed-appliance mechanics | Identical fixed-appliance mechanics without MOPs | Orthodontic tooth movement, baseline to 4 weeks Baseline to 4 weeks · Orthodontic treatment with fixed appliances · Measured distance: Little's Irregularity Index (LII) | SMD 1.71 [0.64, 2.78] Low Downgraded: inconsistency 5 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Depth and jaw: <5 mm in maxilla | SMD 1.42 [0.81, 2.03] GRADE not reported 12 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Jaw, total perforations and depth: <=3, >=5 mm in maxilla | SMD 0.30 [-0.01, 0.60] GRADE not reported 5 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Kumar et al., 2024 | SMD 1.700 [1.228, 2.173] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Probing pocket depth | SMD 0.60 [-2.00, 3.20] Very low Downgraded: imprecision, inconsistency 3 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Sensitivity: available average (no averaging across arms, sites or jaws) | SMD 1.00 [0.57, 1.43] GRADE not reported 19 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Feizbakhsh et al., 2018 | SMD 1.656 [1.180, 2.133] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Depth and jaw: >=5 mm in mandible | SMD 2.43 [-0.38, 5.24] GRADE not reported 2 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to last follow-up (3 weeks to 10 months) · Trim-and-fill (observed plus imputed studies; 0 imputed) | SMD 1.128 [0.994, 1.262] GRADE not reported 39 studies |
| Human orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) of the alveolar cortical bone with fixed-appliance mechanics | Identical fixed-appliance mechanics without MOPs | Orthodontic tooth movement, baseline to 4 weeks Baseline to 4 weeks · Orthodontic treatment with fixed appliances · Leave-one-out sensitivity analysis: omitting Fattori et al., 2020 | SMD 1.699 [1.229, 2.169] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · OTM measurement: Digital scanning | SMD 0.97 [0.46, 1.48] GRADE not reported 14 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Al-Hayek et al., 2019 | SMD 2.760 [1.430, 4.091] GRADE not reported 8 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Jaw and type of OTM: Maxillary canine retraction | SMD 1.60 [0.99, 2.22] GRADE not reported 18 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Total perforations and jaw: <=3 in maxilla and mandible | SMD 1.14 [0.23, 2.05] GRADE not reported 3 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to last follow-up (3 weeks to 10 months) · Repeat of MOP: Yes | SMD 1.04 [0.44, 1.64] GRADE not reported 9 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Measured distance: extraction space (EXT) | MD 0.33 [0.27, 0.39] High 3 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to El Awady et al., 2019 | SMD 2.266 [1.228, 3.304] GRADE not reported 11 studies |
| Human orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) of the alveolar cortical bone with fixed-appliance mechanics | Identical fixed-appliance mechanics without MOPs | Orthodontic tooth movement, baseline to 4 weeks Baseline to 4 weeks · Orthodontic treatment with fixed appliances · Cumulative meta-analysis ordered by year, after adding Mordente et al., 2024 | SMD 1.644 [1.183, 2.104] GRADE not reported 31 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to last follow-up (3 weeks to 10 months) | SMD 1.66 [1.27, 2.05] Moderate Downgraded: inconsistency 39 studies · 1025 participants |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Attachment loss | SMD -0.36 [-1.28, 0.56] Very low Downgraded: imprecision, inconsistency 6 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Babanouri et al., 2020 | SMD 2.173 [1.296, 3.050] GRADE not reported 13 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Alkebsi et al., 2018 | SMD 4.364 [-4.547, 13.274] GRADE not reported 2 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Measured distance: model-based custom references (C-Model) | MD 0.27 [0.01, 0.53] Low Downgraded: inconsistency 8 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Working wire dimension: 0.019 x 0.025 | SMD 1.72 [1.18, 2.26] GRADE not reported 18 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Bansal et al., 2019 | SMD 1.593 [1.130, 2.056] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Attri et al., 2018 | SMD 2.788 [0.476, 5.101] GRADE not reported 3 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Study design: Split mouth | SMD 1.08 [0.55, 1.61] GRADE not reported 14 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Martina et al., 2022 | SMD 1.673 [1.195, 2.152] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Jaw and type of OTM: Maxillary and mandibular alignment | SMD 2.24 [-2.14, 6.62] GRADE not reported 2 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Measured distance: canine to second premolar (C2P) | MD 0.51 [0.26, 0.76] Very low Downgraded: risk of bias, inconsistency 7 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Immediate postoperative pain (VAS) Immediately after the procedure | MD 0.96 [-0.08, 1.99] Very low Downgraded: risk of bias, imprecision, inconsistency 8 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Jaw: Maxilla and mandible | SMD 1.95 [0.92, 2.98] GRADE not reported 5 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Alqadasi et al., 2019 | SMD 2.394 [1.189, 3.599] GRADE not reported 9 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Female proportion: <=60% | SMD 1.77 [1.14, 2.40] GRADE not reported 18 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Total perforations: <=3 | SMD 1.45 [0.86, 2.05] GRADE not reported 18 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Risk of bias subgroup, Allocation concealment (RoB 1): Unclear risk | SMD 1.88 [1.29, 2.47] GRADE not reported 12 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Sahin et al., 2023 | SMD 1.586 [1.116, 2.057] GRADE not reported 27 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Kumar et al., 2024 | SMD 1.561 [1.104, 2.018] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Depth and total perforations: <5 mm and >3 | SMD 2.11 [1.18, 3.03] GRADE not reported 9 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Risk of bias subgroup, Random sequence generation (RoB 1): Low risk | SMD 1.55 [1.01, 2.10] GRADE not reported 23 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Pain change from baseline (VAS) 7 days | SMD 0.16 [-2.34, 2.66] Very low Downgraded: risk of bias, imprecision, inconsistency 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Sahin et al., 2023 | SMD 1.672 [1.196, 2.148] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting RAGHAV et al., 2020 | SMD 1.691 [1.210, 2.172] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks | SMD 1.64 [1.18, 2.10] Moderate Downgraded: inconsistency 31 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Thomas et al., 2021 | SMD 1.574 [1.010, 2.138] GRADE not reported 20 studies |
| Human orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) of the alveolar cortical bone with fixed-appliance mechanics | Identical fixed-appliance mechanics without MOPs | Orthodontic tooth movement, baseline to 4 weeks Baseline to 4 weeks · Orthodontic treatment with fixed appliances · Depth and jaw: 5 mm or more in maxilla | SMD 0.27 [-0.02, 0.56] GRADE not reported 6 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Meta-regression: mean age (years) | Meta-regression coefficient 0.170 GRADE not reported 31 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Singh et al., 2023 | SMD 1.679 [1.200, 2.157] GRADE not reported 28 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Root resorption (mm) | SMD 0.02 [-0.03, 0.07] Moderate Downgraded: imprecision 6 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Meta-regression: orthodontic force (g) | Meta-regression coefficient -0.037 [-0.057, -0.018] GRADE not reported 19 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Leave-one-out: omitting Babanouri et al., 2020 | SMD 1.634 [1.161, 2.107] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Risk of bias subgroup, Blinding of outcome assessment (RoB 1): High risk | SMD 7.53 [-3.07, 18.12] GRADE not reported 2 studies |
| Human orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) of the alveolar cortical bone with fixed-appliance mechanics | Identical fixed-appliance mechanics without MOPs | Orthodontic tooth movement, baseline to 4 weeks Baseline to 4 weeks · Orthodontic treatment with fixed appliances · Total perforations and jaw: more than 3 in maxilla and mandible | SMD 3.47 [1.68, 5.25] GRADE not reported 2 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Sensitivity: calculated average across jaws | SMD 2.36 [1.44, 3.29] GRADE not reported 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Total perforations: >3 | SMD 1.89 [1.15, 2.64] GRADE not reported 13 studies |
| Human orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) of the alveolar cortical bone with fixed-appliance mechanics | Identical fixed-appliance mechanics without MOPs | Orthodontic tooth movement, baseline to 4 weeks Baseline to 4 weeks · Orthodontic treatment with fixed appliances · Leave-one-out sensitivity analysis: omitting Li et al., 2022 | SMD 1.699 [1.227, 2.172] GRADE not reported 30 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Jaw, total perforations and depth: <=3, <5 mm in maxilla and mandible | SMD 1.62 [1.17, 2.07] GRADE not reported 2 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Immediate postoperative pain (VAS) Immediately after the procedure · Study design: Split mouth | MD 0.49 [0.26, 0.72] GRADE not reported 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Instrument for MOP: Miniscrew/mini-implant | SMD 1.52 [1.05, 1.99] GRADE not reported 22 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Alikhani et al., 2013 Unresolved: the two extractors disagree on this row. | SMD 9.030 [6.109, 11.952] GRADE not reported 1 study |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Kundi et al., 2018 | SMD 4.448 [2.205, 6.691] GRADE not reported 5 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Rashid et al., 2018 | SMD 3.787 [1.936, 5.638] GRADE not reported 6 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Immediate postoperative pain (VAS) Immediately after the procedure · Instrument: Propel | MD 1.33 [-1.47, 4.12] GRADE not reported 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Bansal et al., 2019 | SMD 2.472 [1.322, 3.622] GRADE not reported 10 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Martina et al., 2022 | SMD 1.548 [1.034, 2.063] GRADE not reported 23 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Cumulative meta-analysis up to Feizbakhsh et al., 2018 | SMD 2.223 [0.631, 3.815] GRADE not reported 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Depth and instrument: <5 mm with Propel | SMD 2.00 [0.45, 3.56] GRADE not reported 4 studies |
| Orthodontic patients treated with fixed appliances | Micro-osteoperforations (MOPs) | No MOP (identical fixed-appliance mechanics) | Orthodontic tooth movement (standardized, change from baseline) Baseline to 4 weeks · Malocclusion: Crowding | SMD 1.71 [0.64, 2.78] GRADE not reported 5 studies |
Included primary studies 39
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Kumar 2024 Effect of micro-osteoperforations (MOPs) on the rate of en masse orthodontic tooth retraction : A randomized controlled trial. PMID:36018346 | 2024 | 2 other reviews | not stated | not extracted yet |
| Singh 2023 Effect of Mini-implant assisted Micro-osteoperforation on the rate of orthodontic tooth movement-A randomized clinical trial. PMID:38234639 | 2023 | 2 other reviews | not stated | not extracted yet |
| Thomas 2021 Evaluation of physiodispenser assisted micro-osteoperforation on the rate of tooth movement and associated periodontal tissue status… PMID:34112627 | 2021 | 2 other reviews | not stated | not extracted yet |
| Aboalnaga 2019 Effect of micro-osteoperforation on the rate of canine retraction: a split-mouth randomized controlled trial. PMID:31155698 | 2019 | 1 other review | not stated | not extracted yet |
| Alikhani 2013 Effect of micro-osteoperforations on the rate of tooth movement. PMID:24182579 | 2013 | 1 other review | not stated | not extracted yet |
| Alkebsi 2018 Three-dimensional assessment of the effect of micro-osteoperforations on the rate of tooth movement during canine retraction in adults… PMID:29853235 | 2018 | 1 other review | not stated | not extracted yet |
| Alqadasi 2024 Three-dimensional assessment of accelerating orthodontic tooth movement-micro-osteoperforations vs piezocision: A randomized,… PMID:33124098 | 2021 | 1 other review | not stated | not extracted yet |
| Attri 2018 Comparison of rate of tooth movement and pain perception during accelerated tooth movement associated with conventional fixed appliances… PMID:30281397 | 2018 | 1 other review | not stated | not extracted yet |
| Babanouri 2020 Effect of mini-screw-facilitated micro-osteoperforation on the rate of orthodontic tooth movement: a single-center, split-mouth,… PMID:32147751 | 2020 | 1 other review | not stated | not extracted yet |
| Bansal 2019 Effects of mini-implant facilitated micro-osteoperforations in alleviating mandibular anterior crowding: A randomized controlled clinical… PMID:31649899 | 2019 | 1 other review | not stated | not extracted yet |
| Fattori 2020 Micro-osteoperforation effectiveness on tooth movement rate and impact on oral health related quality of life. PMID:33378487 | 2020 | 1 other review | not stated | not extracted yet |
| Golshah 2021 Efficacy of micro-osteoperforation of the alveolar bone by using mini-screw for acceleration of maxillary canine retraction in young adult… PMID:34696998 | 2021 | 1 other review | not stated | not extracted yet |
| Gulduren 2020 Effects of micro-osteoperforations on intraoral miniscrew anchored maxillary molar distalization : A randomized clinical trial. PMID:32095922 | 2020 | 1 other review | not stated | not extracted yet |
| Gumus 2023 Effects of miniscrew-facilitated micro-osteoperforations on the rate of orthodontic tooth movement : A split-mouth, randomized controlled… PMID:35024875 | 2023 | 1 other review | not stated | not extracted yet |
| Joseph 2022 Comparison of Rate of Tooth Movement, Root Resorption and Pulp Vitality during En masse Anterior Retraction with Micro-osteoperforation… DOI:10.7860/jcdr/2022/55298.16802 | 2022 | 1 other review | not stated | not extracted yet |
| Kilinc 2023 Comparison of the effectiveness of piezocision and microosteoperforation in leveling mandibular anterior teeth. PMID:36517376 | 2023 | 1 other review | not stated | not extracted yet |
| Li 2022 The effect of micro-osteoperforations on orthodontic space closure investigated over 12 weeks: a split-mouth, randomized controlled… PMID:35134142 | 2022 | 1 other review | not stated | not extracted yet |
| Mordente 2024 The effect of micro-osteoperforations on the rate of maxillary incisors' retraction in orthodontic space closure: a randomized controlled… PMID:38342823 | 2024 | 1 other review | not stated | not extracted yet |
| Raghav 2022 Effect of micro-osteoperforations on the rate of orthodontic tooth movement and expression of biomarkers: a randomized controlled clinical… PMID:35674571 | 2022 | 1 other review | not stated | not extracted yet |
| Sahin 2023 The effect of micro-osteoperforation on the rate of tooth movement during the alignment stage in patients with mandibular crowding: a… PMID:37167078 | 2023 | 1 other review | not stated | not extracted yet |
| Venkatachalapathy 2022 Effect of Frequency of Micro-osteoperforation on Miniscrew- supported Canine Retraction: A Single-centered, Split-mouth Randomized… PMID:37283011 | 2022 | 1 other review | not stated | not extracted yet |
| Abdelhameed 2018 Evaluation of the Effect of Combined Low Energy Laser Application and Micro-Osteoperforations versus the Effect of Application of Each… PMID:30559886 | 2018 | this review only | not stated | not extracted yet |
| Ahsan 2021 THE USE OF MICRO-OSTEOPERFORATION CONCEPT FOR ACCELERATING DIFFERENTIAL TOOTH MOVEMENT DOI:10.51253/pafmj.v71i3.3341 | 2021 | this review only | not stated | not extracted yet |
| Al-Attar 2022 Effect of mini-implant facilitated micro-osteoperforations on the alignment of mandibular anterior crowding: A randomised controlled… PMID:35575069 | 2022 | this review only | not stated | not extracted yet |
| Al-Hayek 2019 CLINICAL EVALUATION OF THE EFFECT OF MICROOSTEOPERFORATIONS ON THE RATE OF TOOTH MOVEMENT DURING ALLEVIATION OF MANDIBULAR ANTERIOR CROWDING DOI:10.21608/asdj.2019.164531 | 2019 | this review only | not stated | not extracted yet |
| Alfailany 2023 Effectiveness of Flapless Cortico-Alveolar Perforations Using Mechanical Drills Versus Traditional Corticotomy on the Retraction of… PMID:37641723 | 2023 | this review only | not stated | not extracted yet |
| Alqadasi 2019 The Effectiveness of Micro-osteoperforations during Canine Retraction: A Three-dimensional Randomized Clinical Trial. PMID:32039085 | 2019 | this review only | not stated | not extracted yet |
| Bavikati 2022 Effect of micro osteo-perforations (MOP) on the rate of tooth movement and levels of interleukin- 1β - a split mouth study. PMID:35720241 | 2022 | this review only | not stated | not extracted yet |
| El Awady 2019 EFFICACY OF MICRO-OSTEOPERFORATIONS ON THE RATE OF MAXILLARY CANINE RETRACTION: A RANDOMIZED CONTROLLED TRIAL DOI:10.21608/asdj.2019.164500 | 2019 | this review only | not stated | not extracted yet |
| Farag 2021 Evaluation of the Effect of Micro-osteoperforations versus Piezopuncture on the Rate of Orthodontic Tooth Movement Associated with Canine… DOI:10.3889/oamjms.2021.6173 | 2021 | this review only | not stated | not extracted yet |
| Feizbakhsh 2018 The use of micro-osteoperforation concept for accelerating differential tooth movement DOI:10.1016/j.ejwf.2018.04.002 | 2018 | this review only | not stated | not extracted yet |
| Gowda 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Hashem 2024 Clinical Evaluation of Single Versus Repeated Micro-Osteoperforations During Orthodontic Canine Retraction: A Randomized Clinical Trial. PMID:38344550 | 2024 | this review only | not stated | not extracted yet |
| Kundi 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mahmoudi 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Martina 2022 DOI:10.21307/aoj-2022-0038 | NR | this review only | not stated | not extracted yet |
| Ozkan 2021 The effect of different micro-osteoperforation depths on the rate of orthodontic tooth movement: A single-center, single-blind, randomized… PMID:33984223 | 2021 | this review only | not stated | not extracted yet |
| Rasheed 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Rashid 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Human orthodontic patients; patients with systemic bone-metabolism disorders excluded | Orthodontic patients, mostly aged 16 to 28 years, 39 trials (n=1025) |
| Intervention | Any MOP protocol regardless of instrument, perforation depth, number, site or repetition; trials with additional acceleration methods excluded | MOPs, mostly with miniscrews (Propel in a minority), 2 to 21 perforations per session, depth 1 to 8 mm, 29 trials single session and 10 repeated (n=39 trials) |
| Comparison | Identical fixed-appliance mechanics delivered without MOPs | No MOP (control side or control group) with the same fixed-appliance mechanics (n=39 trials) |
| Outcomes | Primary: orthodontic tooth movement (baseline to 4 weeks; baseline to last follow-up). Secondary: pain (VAS immediately after the procedure, change at 24 h and 7 days), root resorption, gingival index, probing pocket depth, anchorage loss; any outcome in 3 or more trials was pooled | Tooth movement SMD at 4 weeks (k=31) and at last follow-up (k=39); MD by measurement method (LII k=5, extraction space k=3, C2P k=7, CL k=6, model-based k=8, C-TAD k=2); root resorption (k=6); attachment loss (k=6); gingival index (k=4); pocket depth (k=3); pain immediate (k=8), 24 h (k=7), 7 days (k=4) |
| Study designs | Parallel-arm or split-mouth randomized controlled trials | 39 randomized controlled trials (about half split-mouth, remainder parallel-arm), 2013 to 2024 |
| Timing | Baseline to 4 weeks; baseline to each study's last follow-up | Follow-up from 3 to 4 weeks up to 12 months |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Yes | Partial Yes | no |
| 3Choice of study designs explained | No | Yes | no |
| 4Comprehensive literature searchcritical | Yes | Yes | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Yes | Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: Yes · NRSI: N/A | NRSI: N/A · RCT: Yes | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: Yes · NRSI: N/A | NRSI: N/A · RCT: Yes | no |
| 12Impact of risk of bias on the pooled results | Yes | Yes | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | Yes | Yes | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Low | Low | yes |