Periodontal disease - novel loci (meta-analysis) · Adults from Japanese and European cohorts (present study + GLIDE + UK Biobank + BioBank Japan); periodontal disease cases vs controls
The meta-analysis found no novel loci for periodontal disease; the European SIGLEC5/chr19 locus did not replicate in Japanese populations; ungraded.
1 finding from 1 review
Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomesLifelong (germline genotype) · Population-based genetic association study (Japanese + European cohorts) · Meta-analysis: present study + GLIDE + UKB + BBJ
Meta-analysis of periodontal disease identified only previously known loci; no novel loci. The chromosome-19 SIGLEC5 locus associated with periodontitis in Europeans was not replicated in Japanese populations (present…
4 studies · 764572 participants
GRADE not reported
Shear bond strength (SBS) of metallic orthodontic brackets · Extracted permanent human teeth (enamel); sound or demineralized
CPP-ACP enamel pre-treatment before bonding did not significantly affect the shear bond strength of metallic orthodontic brackets (MD 1.163 MPa, 95% CI -0.321 to 2.648; ungraded).
1 finding from 1 review
Shear bond strength (SBS) of metallic orthodontic brackets · Sound enamel of extracted permanent human teeth
When used to prevent white spot lesions on sound enamel, CPP-ACP pre-treatment did not significantly affect shear bond strength (MD 1.009, 95% CI -0.723 to 2.740; ungraded).
1 finding from 1 review
MD 1.009 [-0.723, 2.740]
7 studies
GRADE not reported
Shear bond strength (SBS) of metallic orthodontic brackets · Demineralized enamel of extracted permanent human teeth
When used to remineralize white spot lesions on demineralized enamel, CPP-ACP pre-treatment did not significantly affect shear bond strength (MD 1.501, 95% CI -0.630 to 3.632; ungraded).
1 finding from 1 review
MD 1.501 [-0.630, 3.632]
9 studies
GRADE not reported
Early childhood caries (ECC) · Children aged 0-5 years in North Africa
Tooth brushing method was associated with higher odds of ECC (OR 1.435).
1 finding from 1 review
OR 1.435 [1.207, 2.915]
1 study
GRADE not reported
Water samples with fluoride concentration below the acceptable range · Artificially fluoridated public water supply in Brazilian cities (water samples under external control)
In the Northeast Brazilian region, a pooled 79.7% of water samples had fluoride below the acceptable range; ungraded.
2 findings from 1 review
Water samples with fluoride concentration above the acceptable range · Artificially fluoridated public water supply in Brazilian cities (water samples under external control)
In the Southeast Brazilian region, a pooled 11.5% of water samples had fluoride above the acceptable range; ungraded.
2 findings from 1 review
Water samples with fluoride concentration outside the acceptable range · Artificially fluoridated public water supply in Brazilian cities (water samples under external control)
In Brazilian cities using external control, more than half of artificially fluoridated public water supply samples (pooled 56.6%, 95% CI 45.5 to 67.3) had fluoride concentrations outside the acceptable range, with very high heterogeneity (I2=99.5%); ungraded.
3 findings from 1 review
Death · Patients with severe malaria
The fixed-effect NMR reported a difference between artemether and quinine at ages 15 years or more; no GRADE assessment was reported.
2 findings from 1 review
no estimate extracted
Studies not reported
GRADE not reported
no estimate extracted
Studies not reported
GRADE not reported
Pulp necrosis · Vital teeth
The pooled incidence with radiographic assessment was 4.95%.
2 findings from 1 review
Proportion 4.95 [2.43, 8.29]
5 studies · 1853 participants
GRADE not reported
Proportion 5.66 [3.71, 7.99]
24 studies · 6581 participants
GRADE not reported
Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years
A trim-and-fill sensitivity analysis pooling every exposure estimate gave an overall OR of 0.17 (95% CI 0.13-0.21) after correcting for significant publication bias (Fig. 13); this combined estimate spans heterogeneous exposures and is a publication-bias sensitivity result (ungraded).
1 finding from 1 review
Enamel/dental hard-tissue changes and e-liquid cariogenic properties (demineralization, colour change, pH, sugar content, metals) · Oral bacteria (streptococci), dental hard tissue (enamel/dentin) and e-liquids studied in vitro/ex vivo (with a few clinical microbiome…
In vitro evidence suggests e-liquids are often acidic and sugar-containing and can alter enamel/dentin colour and properties, supporting a plausible cariogenic effect, but findings are heterogeneous and not pooled (ungraded, narrative).
1 finding from 1 review
Periodontal parameters (all measures pooled) in OC cases vs controls · Adults in case-control studies (oral cancer patients vs healthy controls)
Pooling all periodontal measures, oral cancer patients had worse periodontal status than controls (SMD 0.95, 95% CI 0.41-1.49; very high heterogeneity, I2=96.8%); ungraded. Note this pools clinically different measures.
1 finding from 1 review
Dental caries · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK Biobank European…
Meta-analysis identified a novel genome-wide-significant locus for dental caries at rs10974056 in GLIS3 (P=3.93E-08); ungraded.
1 finding from 1 review
Dental caries · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK Biobank European…
Meta-analysis identified a novel genome-wide-significant locus for dental caries at rs4801882 in SIGLEC5 (P=1.71E-08); ungraded.
1 finding from 1 review
Impaired OHRQoL measured with CPQ 11-14 (quantitative synthesis / meta-analysis) · Adolescents (10-19 years)
Malocclusion (DAI) probably increases the prevalence of impaired OHRQoL (CPQ 11-14) by about 15% in adolescents (RR/PR 1.15, 95% CI 1.12-1.18; moderate certainty).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · People or specimens with white spot lesions or early caries lesions
The NMA estimated an SMD of -0.78 for P11-4 + fluoride varnish versus CPP-ACP (95% CI -1.33 to -0.28).
1 finding from 1 review
SMD -0.78 [-1.33, -0.24]
Studies not reported
GRADE not reported
Intervention not reported
Calcific metamorphosis (adverse event)
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Unmet dental treatment need · Children aged 1-18 years
Narrative reports from 6 studies suggested greater unmet dental treatment need in children with learning disabilities (5 of 6 studies), but no quantitative data were available (certainty not graded).
1 finding from 1 review
Caries experience (mean DMFT) · Adults aged 19-60 years
Studies of older adults (mean age >33.4 years) had higher pooled DMFT than younger adults, but the age to DMFT meta-regression was not statistically significant; ungraded observational evidence.
5 findings from 1 review
Show 2 more findings