HFNC vs NIPPV or NIV
- High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedVery low
It is very uncertain whether the intervention changes mortality at longest (very low certainty).
Corticosteroids showed no clear difference in long‐term mortalityc compared with placebo or usual care (low certainty).
Corticosteroids showed no clear difference in number of participants with adverse events ‐ superinfection (up to… compared with placebo or usual care (moderate certainty).
Corticosteroids leads to higher number of participants with adverse events ‐ muscle weakness (up to… compared with placebo or usual care (high certainty).
Omega‐3 fatty acids and antioxidants showed no clear difference in all‐cause mortality (longest period reported) compared with placebo or standard nutrition (low certainty).
It is very uncertain whether physical and cognitive therapy changes in‐hospital mortality at 30 days or at the longest compared with standard care (very low certainty).
The review found no eligible studies for this question.
PCT showed no clear difference in mortality at longest compared with non‐PCT (standard care or CRP: primary outcomes) (low certainty).
Thromboelastography (TEG) or thromboelastometry (ROTEM) may leads to lower mortality longest compared with any comparison (low certainty).
Early probably leads to lower mortality at longest compared with late tracheostomy (moderate certainty).
Mortality: prone position showed no clear difference in longer‐term mortality (LTM)Alive or dead compared with supine (low certainty).
Mortality: prone position probably leads to lower subgroup analysis of longer‐term mortality: severe hypoxaemiaAlive… compared with supine (moderate certainty).
Mortality: prone position probably leads to lower subgroup analysis of longer‐term mortality: lower tidal volume… compared with supine (moderate certainty).
Mortality: prone position showed no clear difference in subgroup analysis of longer‐term mortality: ARDS onlyAlive or dead compared with supine (moderate certainty).
Mortality: prone position probably leads to lower subgroup analysis of longer‐term mortality: ≥ 16 hours/d proneAlive… compared with supine (moderate certainty).
Mortality: prone position probably leads to lower subgroup analysis of longer‐term mortality: enrolment ≤ 48 hours… compared with supine (moderate certainty).
It is very uncertain whether prothrombin complex concentrate changes overall mortality ‐ longest compared with any comparator (very low certainty).
Glutamine‐supplemented nutrition showed no clear difference in long‐term mortality (closest to six month) compared with non‐supplemented nutrition (moderate certainty).