Cochrane · systematic review · CD002243
Corticosteroids for treating sepsis in children and adults
Annane, D, Bellissant, E, Bollaert, PE, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 3 · 42.9%High 3 · 42.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 3 versionsCorticosteroids compared to placebo or usual care for treating sepsis
Population: children and adults with sepsis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
28‐Day all‐cause mortalitya Corticosteroids vs placebo or usual care | RR 0.91 [0.84, 0.99] | 50 studies · 11233 participants | Moderate Downgraded: imprecision, inconsistency |
Long‐term mortalityc Corticosteroids vs placebo or usual care | RR 0.97 [0.91, 1.03] | 7 studies · 6236 participants | Low Downgraded: imprecision, inconsistency |
Hospital mortality Corticosteroids vs placebo or usual care | RR 0.9 [0.82, 0.99] | 26 studies · 8183 participants | Moderate Downgraded: imprecision, inconsistency |
Length of intensive care unit stay for all participants in days Corticosteroids vs placebo or usual care | no estimate extracted | 21 studies · 7612 participants | High |
Length of hospital stay for all participants in days Corticosteroids vs placebo or usual care | no estimate extracted | 22 studies · 8795 participants | High |
Number of participants with adverse events ‐ superinfection (up to longest Corticosteroids vs placebo or usual care | RR 1.06 [0.95, 1.19] | 25 studies · 5356 participants | Moderate Downgraded: imprecision, inconsistency |
Number of participants with adverse events ‐ muscle weakness (up to longest Corticosteroids vs placebo or usual care | RR 1.21 [1.01, 1.44] | 6 studies · 6145 participants | High |