Cochrane · systematic review · CD010050
Glutamine supplementation for critically ill adults
Tao, KM, Li, XQ, Yang, LQ, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 5 · 71.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Glutamine‐supplemented nutrition compared to non‐supplemented nutrition for critically ill patients
Population: critically ill patients or receiving major surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Infectious complications Glutamine‐supplemented nutrition vs non‐supplemented nutrition | RR 0.79 [0.71, 0.87] | 33 studies · 2303 participants | Moderate Downgraded: publication bias |
Short‐term mortality (within hospital stay or closest to one month) Glutamine‐supplemented nutrition vs non‐supplemented nutrition | RR 0.89 [0.78, 1.02] | 36 studies · 3454 participants | Low Downgraded: risk of bias, publication bias |
Long‐term mortality (closest to six month) Glutamine‐supplemented nutrition vs non‐supplemented nutrition | RR 1 [0.89, 1.12] | 11 studies · 2277 participants | Moderate Downgraded: risk of bias |
Length of hospital stay Glutamine‐supplemented nutrition vs non‐supplemented nutrition | no estimate extracted | 36 studies · 2963 participants | Low Downgraded: risk of bias, inconsistency |
Length of ICU stay Glutamine‐supplemented nutrition vs non‐supplemented nutrition | no estimate extracted | 22 studies · 2284 participants | Moderate Downgraded: risk of bias |
Days on mechanical ventilation Glutamine‐supplemented nutrition vs non‐supplemented nutrition | no estimate extracted | 14 studies · 1297 participants | Moderate Downgraded: risk of bias |
Serious adverse events Glutamine‐supplemented nutrition vs non‐supplemented nutrition | RR 1.4 [0.77, 2.57] | 2 studies · 856 participants | Moderate |