Cochrane · systematic review · CD012041
Immunonutrition for acute respiratory distress syndrome (ARDS) in adults
Dushianthan, A, Cusack, R, Burgess, VA, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 6 · 85.7%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Omega‐3 fatty acids and antioxidants compared with placebo or standard nutrition for acute respiratory distress syndrome (ARDS)
Population: adults (aged 18 years or older), mechanically ventilated participants with ARDS as defined by the Berlin definition of ARDS or, for older studies, the American‐European Consensus Criteria for both ARDS and acute lung injury
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality (longest period reported) Omega‐3 fatty acids and antioxidants vs placebo or standard nutrition | RR 0.79 [0.59, 1.07] | 10 studies · 1015 participants | Low Downgraded: risk of bias |
ICU LOS (days) Omega‐3 fatty acids and antioxidants vs placebo or standard nutrition | no estimate extracted | 8 studies · 639 participants | Very low Downgraded: risk of bias |
Ventilator days (days) Omega‐3 fatty acids and antioxidants vs placebo or standard nutrition | no estimate extracted | 7 studies · 581 participants | Very low Downgraded: risk of bias |
Indices of oxygenation (measured as PaO₂/FiO₂ ratio at day 4) Omega‐3 fatty acids and antioxidants vs placebo or standard nutrition | no estimate extracted | 7 studies · 659 participants | Very low Downgraded: risk of bias |
Cardiac adverse events (study author reported anytime during study period) Omega‐3 fatty acids and antioxidants vs placebo or standard nutrition | RR 0.87 [0.09, 8.46] | 3 studies · 339 participants | Very low Downgraded: risk of bias |
Gastrointestinal adverse events (study author reported anytime during study period) Omega‐3 fatty acids and antioxidants vs placebo or standard nutrition | RR 1.11 [0.71, 1.75] | 4 studies · 427 participants | Very low Downgraded: risk of bias |
Total number of adverse events (study author reported anytime during study period) Omega‐3 fatty acids and antioxidants vs placebo or standard nutrition | RR 0.91 [0.67, 1.23] | 5 studies · 517 participants | Very low Downgraded: risk of bias |