Cochrane · systematic review · CD008095
Prone position for acute respiratory failure in adults
Bloomfield, R, Noble, DW, Sudlow, A · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 5 · 71.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Mortality: prone position compared with supine for acute respiratory failure in adults requiring mechanical ventilation in intensive care
Population: adults with acute respiratory failure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Short‐term mortality (STM)Alive or dead Mortality: prone position vs supine | RR 0.84 [0.69, 1.02] | 8 studies · 2117 participants | Low Downgraded: risk of bias, inconsistency |
Longer‐term mortality (LTM)Alive or dead Mortality: prone position vs supine | RR 0.86 [0.72, 1.03] | 8 studies · 2141 participants | Low Downgraded: risk of bias, inconsistency |
Subgroup analysis of longer‐term mortality: severe hypoxaemiaAlive or dead Mortality: prone position vs supine | RR 0.77 [0.65, 0.92] | 7 studies · 977 participants | Moderate Downgraded: risk of bias |
Subgroup analysis of longer‐term mortality: lower tidal volume ventilationAlive or dead Mortality: prone position vs supine | RR 0.73 [0.55, 0.96] | 5 studies · 911 participants | Moderate Downgraded: risk of bias |
Subgroup analysis of longer‐term mortality: ARDS onlyAlive or dead Mortality: prone position vs supine | RR 0.85 [0.71, 1.01] | 8 studies · 1758 participants | Moderate Downgraded: risk of bias |
Subgroup analysis of longer‐term mortality: ≥ 16 hours/d proneAlive or dead Mortality: prone position vs supine | RR 0.77 [0.61, 0.99] | 5 studies · 1005 participants | Moderate Downgraded: risk of bias |
Subgroup analysis of longer‐term mortality: enrolment ≤ 48 hours after entry criteria/ventilationAlive or dead Mortality: prone position vs supine | RR 0.75 [0.59, 0.94] | 5 studies · 1024 participants | Moderate Downgraded: risk of bias |