Cochrane · systematic review · CD010959
Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or septic shock
Andriolo, BNG, Andriolo, RB, Salomão, R, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
1
Included studies
NR
No studies 1 · 16.7%Ungraded 0 · 0%Very low 1 · 16.7%Low 3 · 50%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
PCT versus non‐PCT (standard care or CRP: primary outcomes) for reducing mortality in adult patients with sepsis, severe sepsis and septic shock
Population: adult patients with sepsis, severe sepsis and septic shock
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at longest PCT vs non‐PCT (standard care or CRP: primary outcomes) | RR 0.81 [0.65, 1.01] | 10 studies · 1156 participants | Low Downgraded: risk of bias |
Mortality at 28 days PCT vs non‐PCT (standard care or CRP: primary outcomes) | RR 0.89 [0.61, 1.31] | 4 studies · 316 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Mortality at ICU discharge PCT vs non‐PCT (standard care or CRP: primary outcomes) | RR 1.03 [0.5, 2.11] | 3 studies · 506 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Mortality at hospital discharge PCT vs non‐PCT (standard care or CRP: primary outcomes) | RR 0.98 [0.75, 1.27] | 7 studies · 805 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Time receiving antimicrobial therapy (days) ‐ mean (SD) PCT vs non‐PCT (standard care or CRP: primary outcomes) | no estimate extracted | 4 studies · 313 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Participants with antimicrobial regimen changed from a broad to a narrower spectrum PCT vs non‐PCT (standard care or CRP: primary outcomes) | no estimate extracted | NR | No studies |