Cochrane · systematic review · CD010555
Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and non‐bleeding patients
Johansen, M, Wikkelsø, A, Lunde, J, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Prothrombin complex concentrate versus any comparator for reversal of vitamin K antagonist treatment in bleeding and non‐bleeding patients
Population: patients with vitamin K antagonist‐induced bleeding requiring acute intervention
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall mortality ‐ longest Prothrombin complex concentrate vs any comparator | RR 0.93 [0.37, 2.33] | 3 studies · 421 participants | Very low Downgraded: risk of bias, imprecision |
Number of new occurrences of RBC transfusion Prothrombin complex concentrate vs any comparator | RR 1.08 [0.82, 1.43] | 2 studies · 376 participants | Very low Downgraded: risk of bias |
Number of complications probably related to the intervention Prothrombin complex concentrate vs any comparator | RR 0.92 [0.78, 1.09] | 4 studies · 442 participants | Very low Downgraded: risk of bias, imprecision |
Transfusion of RBCs Prothrombin complex concentrate vs any comparator | no estimate extracted | 2 studies · 370 participants | Very low Downgraded: risk of bias |