Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

70 questions · 75 findings · 11 reviews · Pain, Palliative and Supportive Care

No studies found 14 · 18.7%GRADE not reported 1 · 1.3%Very low 35 · 46.7%Low 18 · 24%Moderate 4 · 5.3%High 3 · 4%

Application of heat vs application of cold

Adverse events due to treatment Minor adverse events, reported in studies as: exacerbation in pain after treatment; burn as a result of hot‐water immersion, or transient erythema, or adverse effects due to application of ice · people stung accidentally by bluebottle jellyfish (Physalia) and box jellyfish that do not cause Irukandji syndrome (Hawaiian box…

It is very uncertain whether application of heat changes adverse events due to treatment Minor adverse events, reported in… compared with application of cold (very low certainty).

1 finding from 1 review

Intervention not reported

Survival time from onset of inoperable MBO until death. · Adults 18 yrs and over with malignant bowel obstruction (MBO) as defined by the International Conference on MBO, with no indication for…

The review found no eligible studies for this question.

1 finding from 1 review

Summary of Findings Table ‐ Ibuprofen 300 mg vs paracetamol

Number of participants reporting an adverse event · health problem or population

It is very uncertain whether summary of Findings Table ‐ Ibuprofen 300 mg changes number of participants reporting or experiencing any adverse event compared with active comparator (acetaminophen) (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Ibuprofen 300 mg vs paracetamol

At least 50% reduction in pain · health problem or population

It is very uncertain whether summary of Findings Table ‐ Ibuprofen 300 mg changes number of participants with at least 50% pain relief at 4 hours compared with active comparator (acetaminophen) (very low certainty).

2 findings from 1 review

Intravenous diclofenac vs placebo

At least 50% reduction in pain · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

Intravenous diclofenac may leads to higher number of participants with at least 50% pain relief at 4 hours compared with placebo (low certainty).

2 findings from 1 review

Intravenous diclofenac vs NSAIDs

Number of participants using rescue medication over 4 to 6 hours postinterventions · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

It is very uncertain whether intravenous diclofenac changes number of participants using rescue medication over 4 to 6 hours… compared with another NSAID (very low certainty).

1 finding from 1 review

Intravenous diclofenac vs NSAIDs

Number of participants reporting an adverse event · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

Intravenous diclofenac showed no clear difference in number of participants reporting any adverse event compared with another NSAID (low certainty).

1 finding from 1 review

Intravenous diclofenac vs NSAIDs

Number of participants experiencing any serious adverse events · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

Intravenous diclofenac showed no clear difference in number of participants experiencing a serious adverse event compared with another NSAID (low certainty).

1 finding from 1 review

Intravenous diclofenac vs placebo

Number of participants using rescue medication over 4 to 6 hours postinterventions · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

Intravenous diclofenac may leads to lower number of participants using rescue medication over 4 to 6 hours… compared with placebo (low certainty).

1 finding from 1 review

Intravenous diclofenac vs placebo

Number of participants reporting an adverse event · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

Intravenous diclofenac showed no clear difference in number of participants reporting any adverse event compared with placebo (low certainty).

1 finding from 1 review