Cochrane · systematic review · CD012498
Single‐dose intravenous diclofenac for acute postoperative pain in adults
McNicol, ED, Ferguson, MC, Schumann, R · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
11
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 8.3%Very low 2 · 16.7%Low 9 · 75%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intravenous diclofenac compared to placebo for acute postoperative pain in adults
Population: Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of participants with at least 50% pain relief at 4 hours Intravenous diclofenac vs placebo | RR 2.8 [2, 4] | 3 studies · 277 participants | Low Downgraded: risk of bias, inconsistency |
Number of participants with at least 50% pain relief at 6 hours Intravenous diclofenac vs placebo | RR 1.8 [1.4, 2.2] | 4 studies · 436 participants | Low Downgraded: risk of bias, inconsistency |
Median (or mean) time to use of rescue medication Intravenous diclofenac vs placebo | no estimate extracted | 5 studies · 542 participants | Low Downgraded: risk of bias, imprecision |
Number of participants using rescue medication over 4 to 6 hours postinterventions Intravenous diclofenac vs placebo | RR 0.59 [0.48, 0.73] | 2 studies · 235 participants | Low Downgraded: risk of bias |
Number of participants reporting any adverse event Intravenous diclofenac vs placebo | RR 0.99 [0.86, 1.1] | 2 studies · 296 participants | Low Downgraded: risk of bias |
Number of participants experiencing a serious adverse event Intravenous diclofenac vs placebo | RR 1 [0.15, 7.02] | 5 studies · 472 participants | Low Downgraded: risk of bias |
Intravenous diclofenac compared to another NSAID for acute postoperative pain in adults
Population: Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of participants with at least 50% pain relief at 4 hours Intravenous diclofenac vs another NSAID | no estimate extracted | 0 participants | Ungraded |
Number of participants with at least 50% pain relief at 6 hours Intravenous diclofenac vs another NSAID | RR 0.94 [0.83, 1.1] | 3 studies · 360 participants | Low Downgraded: risk of bias |
Median (or mean) time to use of rescue medication Intravenous diclofenac vs another NSAID | no estimate extracted | 1 study · 169 participants | Very low Downgraded: risk of bias, imprecision |
Number of participants using rescue medication over 4 to 6 hours postinterventions Intravenous diclofenac vs another NSAID | RR 1.8 [1, 3.3] | 1 study · 98 participants | Very low Downgraded: risk of bias |
Number of participants reporting any adverse event Intravenous diclofenac vs another NSAID | RR 0.93 [0.82, 1.1] | 2 studies · 265 participants | Low Downgraded: risk of bias |
Number of participants experiencing a serious adverse event Intravenous diclofenac vs another NSAID | RR 0.94 [0.13, 6.6] | 4 studies · 423 participants | Low Downgraded: risk of bias |