Cochrane · systematic review · CD013264
Single‐dose intravenous ibuprofen for acute postoperative pain in adults
Ferguson, MC, Schumann, R, Gallagher, S, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
10
No studies
2
Included studies
NR
No studies 2 · 16.7%Ungraded 0 · 0%Very low 9 · 75%Low 1 · 8.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of Findings Table ‐ Ibuprofen vs. Placebo for health problem or population
Population: health problem or population
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of participants with at least 50% pain relief at 4 hours Summary of Findings Table ‐ Ibuprofen vs Placebo | RR 1.44 [0.77, 2.66] | 1 study · 126 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Number of participants with at least 50% pain relief at 6 hours Summary of Findings Table ‐ Ibuprofen vs Placebo | RR 1.44 [0.77, 2.66] | 1 study · 126 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Number of participants using rescue medication over a 4‐hour period and over a 6‐hour period postintervention ‐ not reported Summary of Findings Table ‐ Ibuprofen vs Placebo | no estimate extracted | NR | No studies |
Median time to use of rescue medication (use of rescue medication) Summary of Findings Table ‐ Ibuprofen vs Placebo | no estimate extracted | 1 study · 126 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Number of participants reporting or experiencing any adverse event Summary of Findings Table ‐ Ibuprofen vs Placebo | RR 0.98 [0.81, 1.19] | 1 study · 126 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Number of participants reporting or experiencing a serious adverse event Summary of Findings Table ‐ Ibuprofen vs Placebo | no estimate extracted | 1 study · 1 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Summary of Findings Table ‐ Ibuprofen 300 mg compared to active comparator (acetaminophen) for adults with acute postoperative pain after bunionectomy (with osteotomy and internal fixation)
Population: health problem or population
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of participants with at least 50% pain relief at 4 hours Summary of Findings Table ‐ Ibuprofen 300 mg vs active comparator (acetaminophen) | RR 0.91 [0.58, 1.43] | 1 study · 151 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Number of participants with at least 50% pain relief at 6 hours Summary of Findings Table ‐ Ibuprofen 300 mg vs active comparator (acetaminophen) | RR 1.03 [0.64, 1.66] | 1 study · 151 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Number of participants using rescue medication over a 4‐hour period and over a 6‐hour period postintervention ‐ not reported Summary of Findings Table ‐ Ibuprofen 300 mg vs active comparator (acetaminophen) | no estimate extracted | NR | No studies |
Median time to use of rescue medication Summary of Findings Table ‐ Ibuprofen 300 mg vs active comparator (acetaminophen) | no estimate extracted | 1 study · 151 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Number of participants reporting or experiencing any adverse event Summary of Findings Table ‐ Ibuprofen 300 mg vs active comparator (acetaminophen) | RR 1.27 [1.02, 1.59] | 1 study · 151 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Number of participants reporting or experiencing a serious adverse event Summary of Findings Table ‐ Ibuprofen 300 mg vs active comparator (acetaminophen) | no estimate extracted | 1 study · 1 participants | Very low Downgraded: risk of bias, imprecision, indirectness |