Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

119 questions · 121 findings · 22 reviews · Headline outcomes only

No studies found 12 · 9.9%GRADE not reported 7 · 5.8%Very low 36 · 29.8%Low 43 · 35.5%Moderate 19 · 15.7%High 4 · 3.3%

Cells vs no cells

All‐cause mortality ‐ short‐term · Anyone diagnosed with AMI

Cells showed no clear difference in all‐cause mortality ‐ short‐term compared with no cells (moderate certainty).

1 finding from 1 review

Cells vs no cells

All‐cause mortality ‐ long‐term · Anyone diagnosed with AMI

Cells showed no clear difference in all‐cause mortality ‐ long‐term compared with no cells (moderate certainty).

1 finding from 1 review

Cells vs no cells

Cardiovascular mortality · Anyone diagnosed with AMI

Cells showed no clear difference in cardiovascular mortality ‐ short‐term compared with no cells (moderate certainty).

2 findings from 1 review

Cells vs no cells

Composite death, reinfarction and hospitalisation for heart failure ‐ short‐term · Anyone diagnosed with AMI

Cells showed no clear difference in composite death, reinfarction and hospitalisation for heart failure… compared with no cells (moderate certainty).

1 finding from 1 review

Cells vs no cells

Composite death, reinfarction and hospitalisation for heart failure ‐ long‐term · Anyone diagnosed with AMI

Cells showed no clear difference in composite death, reinfarction and hospitalisation for heart failure… compared with no cells (moderate certainty).

1 finding from 1 review

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

All‐cause mortality ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes all‐cause mortality ( compared with control (very low certainty).

1 finding from 1 review

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Reduction in pain Various scales including VAS, PISQ; scales ranged from 0 to 4/10/100, where 0 = no pain ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
1 finding from 1 review

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Amputation · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes incidence of amputation ( compared with control (very low certainty).

1 finding from 1 review

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Angiographic analysis · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

The review found no eligible studies for this question.

1 finding from 1 review

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Increase in ABI An ABI ratio of 0.9 or less indicates PAD. Values between 0.9 and 1.0 are borderline, and above 1.0 is considered normal ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
1 finding from 1 review

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Complications and side effects · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes side effects and complications ( compared with control (very low certainty).

1 finding from 1 review

Lateral decubitus position vs sitting position

Successful lumbar puncture procedure at the first attempt, with < 10000 red blood cells/mm3№ of participants: 1249(2 RCTs) · lumbar puncture in newborn infants

Lateral decubitus position showed no clear difference in successful lumbar puncture procedure at the first attempt, with <… compared with sitting position (moderate certainty).

1 finding from 1 review

Intervention not reported

Proportion of participants with success, defined as 0 to trace cells or 2‐step decrease in activity SUN‐grading ( · Participants with a diagnosis of JIA and uveitis who are aged 2 to 18 years old

The intervention showed no clear difference in proportion of participants with success, defined as 0 to trace cells… (low certainty).

1 finding from 1 review