Cochrane · systematic review · CD012779
Prophylactic platelet transfusions prior to surgery for people with a low platelet count
Estcourt, LJ, Malouf, R, Doree, C, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
9
No studies
12
Included studies
NR
No studies 12 · 57.1%Ungraded 0 · 0%Very low 9 · 42.9%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Prophylactic platelet transfusion prior to surgery versus no prophylactic platelet transfusion prior to surgery
Population: people with a low platelet count
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality within 30 days of surgery Prophylactic platelet transfusion prior to surgery vs no prophylactic platelet transfusion prior to surgery | RR 0.78 [0.41, 1.45] | 1 study · 72 participants | Very low Downgraded: indirectness |
Mortality secondary to bleeding within 30 days of surgery – not reported Prophylactic platelet transfusion prior to surgery vs no prophylactic platelet transfusion prior to surgery | no estimate extracted | NR | No studies |
Mortality secondary to thromboembolism within 30 days of surgery – not reported Prophylactic platelet transfusion prior to surgery vs no prophylactic platelet transfusion prior to surgery | no estimate extracted | NR | No studies |
Mortality secondary to infection within 30 days of surgery – not reported Prophylactic platelet transfusion prior to surgery vs no prophylactic platelet transfusion prior to surgery | no estimate extracted | NR | No studies |
Number of participants with major bleeding within 7 days of surgery (surgical site bleeding requiring a second intervention or reoperation or surgical site bleeding that causes a haematoma or haemarthrosis of sufficient size to delay mobilisation ... Prophylactic platelet transfusion prior to surgery vs no prophylactic platelet transfusion prior to surgery | RR 1.6 [0.29, 8.92] | 1 study · 64 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
The number of participants with minor procedure‐related bleeding within 7 days of surgery Prophylactic platelet transfusion prior to surgery vs no prophylactic platelet transfusion prior to surgery | RR 1.29 [0.9, 1.85] | 1 study · 64 participants | Very low Downgraded: indirectness |
Serious adverse events (surgery‐related adverse effects within 30 days) Prophylactic platelet transfusion prior to surgery vs no prophylactic platelet transfusion prior to surgery | no estimate extracted | 1 study · 64 participants | Very low Downgraded: indirectness |
Prophylactic platelet transfusion prior to surgery versus alternative treatments
Population: people with a low platelet count
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality within 30 days of surgery – not reported Prophylactic platelet transfusion prior to surgery vs alternative treatments | no estimate extracted | NR | No studies |
Mortality secondary to bleeding within 30 days of surgery – not reported Prophylactic platelet transfusion prior to surgery vs alternative treatments | no estimate extracted | NR | No studies |
Mortality secondary to thromboembolism within 30 days of surgery – not reported Prophylactic platelet transfusion prior to surgery vs alternative treatments | no estimate extracted | NR | No studies |
Mortality secondary to infection within 30 days of surgery – not reported Prophylactic platelet transfusion prior to surgery vs alternative treatments | no estimate extracted | NR | No studies |
Number of participants with major bleeding within 7 days of surgery (bleeding that required ≥ 2 units of whole blood/red blood cells within 24 hours of the bleeding) Prophylactic platelet transfusion prior to surgery vs alternative treatments | no estimate extracted | 1 study · 36 participants | Very low Downgraded: risk of bias |
Number of participants with minor procedure‐related bleeding within 7 days of surgery Prophylactic platelet transfusion prior to surgery vs alternative treatments | RR 0.89 [0.06, 13.23] | 1 study · 36 participants | Very low Downgraded: risk of bias |
Serious adverse events (transfusion‐related adverse effects within 24 hours of the transfusion) Prophylactic platelet transfusion prior to surgery vs alternative treatments | RR 2.7 [0.12, 62.17] | 1 study · 36 participants | Very low Downgraded: risk of bias |
Different platelet count thresholds for administering a prophylactic platelet transfusion prior to surgery
Population: people with a low platelet count
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality within 30 days of surgery – not reported | no estimate extracted | NR | No studies |
Mortality secondary to bleeding within 30 days of surgery – not reported | no estimate extracted | NR | No studies |
Mortality secondary to thromboembolism within 30 days of surgery – not reported | no estimate extracted | NR | No studies |
Mortality secondary to infection within 30 days of surgery – not reported | no estimate extracted | NR | No studies |
Number of participants with major bleeding within 7 days of surgery | no estimate extracted | 1 study · 65 participants | Very low Downgraded: indirectness |
Number of participants with minor procedure‐related bleeding within 7 days of surgery | no estimate extracted | 1 study · 65 participants | Very low Downgraded: indirectness |
Serious adverse events – not reported | no estimate extracted | NR | No studies |