All‐cause mortality ‐ short‐term · Anyone diagnosed with AMI
Cells showed no clear difference in all‐cause mortality ‐ short‐term compared with no cells (moderate certainty).
1 finding from 1 review
All‐cause mortality ‐ long‐term · Anyone diagnosed with AMI
Cells showed no clear difference in all‐cause mortality ‐ long‐term compared with no cells (moderate certainty).
1 finding from 1 review
Cardiovascular mortality · Anyone diagnosed with AMI
Cells showed no clear difference in cardiovascular mortality ‐ short‐term compared with no cells (moderate certainty).
2 findings from 1 review
Composite death, reinfarction and hospitalisation for heart failure ‐ short‐term · Anyone diagnosed with AMI
Cells showed no clear difference in composite death, reinfarction and hospitalisation for heart failure… compared with no cells (moderate certainty).
1 finding from 1 review
Composite death, reinfarction and hospitalisation for heart failure ‐ long‐term · Anyone diagnosed with AMI
Cells showed no clear difference in composite death, reinfarction and hospitalisation for heart failure… compared with no cells (moderate certainty).
1 finding from 1 review
HIV-related oral lesions · Children and adolescents living with HIV on ART/HAART
Lower CD4+ counts (<250 cells/mm3) were associated with roughly twice the odds of HIV-related oral lesions in two studies (not pooled).
1 finding from 1 review
Oral Health Status of Children and Adolescents Living with HIV Undergoing Antiretroviral Therapy: A Systematic Review… 2022 All outcomesCross-sectional (case-control; single time point) · HIV pediatric/ART clinics, AIDS centers, and hospitals in Brazil, India, Saudi Arabia, and West Africa (Cote d'Ivoire, Mali, Senegal) · CD4+ T-cell count <250 cells/mm3 vs higher
CLWH with CD4+ <250 cells/mm3 were about twice as likely to have HIV-related oral lesions: Baghirath 2013 OR 1.916 (95% CI 0.613 to 2.513), p=0.001; Divakar 2015 OR 1.999 (95% CI 0.129 to 3.688), p=0.001. Not pooled.
2 studies
GRADE not reported
All‐cause mortality ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes all‐cause mortality ( compared with control (very low certainty).
1 finding from 1 review
Reduction in pain Various scales including VAS, PISQ; scales ranged from 0 to 4/10/100, where 0 = no pain ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
1 finding from 1 review
Amputation · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes incidence of amputation ( compared with control (very low certainty).
1 finding from 1 review
Angiographic analysis · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Increase in ABI An ABI ratio of 0.9 or less indicates PAD. Values between 0.9 and 1.0 are borderline, and above 1.0 is considered normal ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
1 finding from 1 review
Increase in PFWD (m) ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
1 finding from 1 review
Complications and side effects · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes side effects and complications ( compared with control (very low certainty).
1 finding from 1 review
HIV-related oral lesions · Children living with HIV receiving ART
One reported study did not show a clear difference in HIV-related oral lesions for children with CD4+ T-cell counts below 250 cells/mm3.
2 findings from 1 review
OR 1.916 [0.613, 2.513]
1 study
GRADE not reported
OR 1.999 [0.129, 3.688]
1 study
GRADE not reported
Successful lumbar puncture procedure at the first attempt, with < 10000 red blood cells/mm3№ of participants: 1249(2 RCTs) · lumbar puncture in newborn infants
Lateral decubitus position showed no clear difference in successful lumbar puncture procedure at the first attempt, with <… compared with sitting position (moderate certainty).
1 finding from 1 review
RR 0.99 [0.88, 1.12]
Studies not reported
Moderate
Intervention not reported
Proportion of participants with success, defined as 0 to trace cells or 2‐step decrease in activity SUN‐grading ( · Participants with a diagnosis of JIA and uveitis who are aged 2 to 18 years old
The intervention showed no clear difference in proportion of participants with success, defined as 0 to trace cells… (low certainty).
1 finding from 1 review
Intervention not reported
Change from baseline in blood eosinophils (cells x 10*9/L) · children and adults with asthma
1 finding from 1 review
Number of sickle cells, peripheral erythroblasts and reticulocytes · children with SCD
1 finding from 1 review
Major bleeding, requiring transfusion of packed red blood cells · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions
1 finding from 1 review
Conjunctival goblet cell density (cells per unit) at 6 months · people with dry eye
1 finding from 1 review