Cochrane · systematic review · CD013818
Tumor necrosis factor (TNF) inhibitors for juvenile idiopathic arthritis‐associated uveitis
Renton, WD, Jung, J, Palestine, AG · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 5 · 83.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings
Population: Participants with a diagnosis of JIA and uveitis who are aged 2 to 18 years old
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of participants with success, defined as 0 to trace cells or 2‐step decrease in activity SUN‐grading ( | RR 0.66 [0.21, 2.1] | 2 studies · 43 participants | Low Downgraded: imprecision |
Risk of failure defined as 2‐step increase in activity in SUN grading ( | RR 0.31 [0.01, 7.15] | 1 study · 31 participants | Low Downgraded: imprecision |
Risk of recurrence and mean time‐to‐recurrence after induction of remission at 2 or 6 months | no estimate extracted | NR | Very low Downgraded: imprecision |
Mean change from baseline in logMAR visual acuity at 6 months*2 | no estimate extracted | 1 study · 90 participants | Low Downgraded: imprecision |
Mean change from baseline in number of topical or systemic steroids at 6 months*2 | no estimate extracted | NR | Low Downgraded: imprecision |
Frequency and nature of adverse effects | no estimate extracted | 3 studies · 134 participants | Low Downgraded: imprecision |