Cochrane · systematic review · CD008347
Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia
Moazzami, B, Mohammadpour, Z, Zabala, ZE, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
VascularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 5 · 71.4%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intramuscular injection of bone marrow mononuclear cells (BMMNC) compared to control for treatment of critical lower limb ischaemia (CLI)
Population: people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality ( Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control | RR 1 [0.15, 6.63] | 3 studies · 123 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Reduction in pain Various scales including VAS, PISQ; scales ranged from 0 to 4/10/100, where 0 = no pain ( Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control | no estimate extracted | 4 studies · 176 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Incidence of amputation ( Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control | RR 0.52 [0.27, 0.99] | 4 studies · 176 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Angiographic analysis Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control | no estimate extracted | NR | No studies |
Increase in ABI An ABI ratio of 0.9 or less indicates PAD. Values between 0.9 and 1.0 are borderline, and above 1.0 is considered normal ( Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control | no estimate extracted | 4 studies · 176 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Increase in PFWD (m) ( Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control | no estimate extracted | 1 study · 53 participants | Low Downgraded: imprecision, inconsistency |
Side effects and complications ( Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control | RR 2.13 [0.5, 8.97] | 4 studies · 176 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |