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Evidence found and GRADE certainty

3,556 questions · 10,375 findings · 429 reviews · Oral Health

No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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Neocone vs Alvogyl

Mean time to resolution of pain · Adults (>18 years) with established dry socket following permanent tooth extraction

Neocone led to lower time to complete resolution of pain (days) compared with alvogyl; GRADE not reported.

1 finding from 1 review

Any preprocedural mouth rinse vs Placebo, no rinsing or control

Adverse events such as transient discolouration, altered taste, allergic reaction, hypersensitivity · People undergoing aerosol-generating procedures (AGPs) in a dental setting

The review found no eligible studies for this question.

1 finding from 1 review

Primary school-based interventions (one or more of: school health policy, oral health education, healthy school environment, access to oral health services, community involvement) vs usual practice

Dental caries prevalence measured by dmft or DMFT/S score greater than one · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs)

School-based interventions may reduce the prevalence of dental caries (RR 0.70, favouring intervention), but the certainty of evidence is very low.

3 findings from 1 review

Any preprocedural mouth rinse vs Placebo, no rinsing or control

Incidence of infection of dental healthcare providers · People undergoing aerosol-generating procedures (AGPs) in a dental setting

The review found no eligible studies for this question.

1 finding from 1 review

Amoxicillin + metronidazole + SRP vs Supragingival scaling (plus placebo)

Cardiovascular events · People with periodontitis and metabolic syndrome (no CVD; primary prevention)

It is very uncertain whether scaling and root planing (SRP) plus antibiotics (amoxicillin and… changes all cardiovascular events compared with supragingival scaling (plus placebo) (very low certainty).

1 finding from 1 review

Teriparatide 20 microg daily in addition to standard care vs placebo + standard care

Healing of MRONJ · People with established (manifest) MRONJ

Teriparatide 20 microg daily in addition to standard care showed no clear difference in healing of MRONJ (resolution of lesions) compared with placebo in addition to standard care (low certainty).

1 finding from 1 review

Socioeconomic status category vs Children without dental caries

Dental caries · Children (deciduous and/or permanent dentition) in low- and middle-income countries

High SES showed no significant association with dental caries (OR 1.03, 95% CI 0.81 to 1.31; 5 studies; not GRADE-rated).

2 findings from 1 review

Pulpotomy with Biodentine vs Pulpotomy with calcium hydroxide (Ca(OH)2)

Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure

Biodentine had a significantly higher pulpotomy success rate than calcium hydroxide (indirect comparison; numeric estimate not available); ungraded.

1 finding from 1 review

Chlorhexidine vs Ozonated water

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them

It is very uncertain whether chlorhexidine (CHX) changes reduction in level of contamination by particles >5 um (droplets) at… compared with ozonated water (very low certainty).

1 finding from 1 review

Hope-based intervention vs Pain education

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People aged 12 years and over with painful TMD lasting 3 months or longer

Hope-based intervention showed no clear difference in pain intensity compared with pain education; GRADE not reported.

1 finding from 1 review

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Swelling or flare-up · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption

It is very uncertain whether single-visit root canal treatment changes swelling or flare-up compared with multiple-visit root canal treatment (two or more visits) (very low certainty).

1 finding from 1 review

Fluoride-releasing resin-based sealant vs No sealant (control/no treatment)

Mean caries increment (mean number of new cavitated occlusal lesions) · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department, dental hospital, France)
1 finding from 1 review
  • Sealants for preventing dental caries in primary teeth 2022 · Cochrane All outcomes
    24 months
    Mean number of new cavitated occlusal lesions 0.23 (SD 0.06) in sealed molars vs 0.29 (SD 0.06) in control molars (Wilcoxon matched-pairs signed-rank test P = 0.42)
    1 study · 85 participants
    GRADE not reported

Sociodemographic / socioeconomic factors (single-parent family, low parental education, family income, socioeconomic status) vs Absence of the factor / reference socioeconomic category

Caries increment in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)

Evidence on the association between sociodemographic/socioeconomic factors and permanent-teeth caries is weak and inconsistent (3 studies; could not be pooled; not GRADE-rated).

1 finding from 1 review

High-viscosity glass-ionomer cement (HVGIC) restoration (conventional restorative approach) vs Compomer, composite resin, or another HVGIC

Treatment failure (annual failure rate) · Children with previously unrestored, vital carious lesions in primary teeth (no pulp therapy); aged 1.5-11 years

High-viscosity GIC had a wide annual failure rate (2.9-25.6%) and was outperformed by compomer/composite in some trials (3 RCTs); low quality of evidence (ungraded).

1 finding from 1 review

Periodontal treatment: scaling and root planing (SRP) plus advice vs Community care: advice only

All CVD-related death · Patients with cardiovascular disease and chronic periodontitis

The review found no eligible studies for this question.

1 finding from 1 review