Question · asked by 1 review
Amoxicillin + metronidazole + SRP vs Supragingival scaling (plus placebo): Cardiovascular events
- Population
- People with periodontitis and metabolic syndrome (no CVD; primary prevention)
- Intervention
- Amoxicillin + metronidazole + SRP
- Comparison
- Supragingival scaling (plus placebo)
- Outcome
- Cardiovascular events
It is very uncertain whether scaling and root planing (SRP) plus antibiotics (amoxicillin and… changes all cardiovascular events compared with supragingival scaling (plus placebo) (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Scaling and root planing (SRP) plus antibiotics (amoxicillin and metronidazole) vs Supragingival scaling (plus placebo) All cardiovascular events · People with periodontitis and metabolic syndrome (no CVD; primary prevention) · 12 months It is very uncertain whether scaling and root planing (SRP) plus antibiotics (amoxicillin and… changes all cardiovascular events compared with supragingival scaling (plus placebo) (very low certainty). Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis (2022) · Cochrane All outcomes | Peto OR 7.77 [1.07, 56.1] | 1 study · 165 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis 2022 · Cochrane All outcomes | 2021-11 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.