Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for ACVD-related events (13 studies, I2=75%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
3 findings from 1 review
Optical/esthetic improvement (DIAGNOdent reading) · Patients (mainly children) with white spot lesions (WSL)
Resin infiltration produced significantly greater optical improvement than fluoride varnish (MD 4.76, 95% CI 0.74 to 8.78; moderate certainty).
3 findings from 1 review
MD 4.76 [0.74, 8.78]
3 studies · 212 participants
Moderate
MD 3.65 [0.82, 6.48]
2 studies · 172 participants
GRADE not reported
MD 13.15 [3.98, 22.32]
1 study · 40 participants
GRADE not reported
Percentage of bleeding on probing (BOP) · Adults undergoing orthodontic treatment
No clear difference in bleeding on probing between aligners and fixed appliances in adults at 6-12 weeks (MD -0.26, 95% CI -0.77 to 0.26; very low certainty).
1 finding from 1 review
Occlusal caries detection accuracy · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces
No eligible QLF studies met the meta-analysis inclusion criteria (candidate QLF studies were identified but none had acceptable index/reference tests and reporting quality).
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Intervention not reported
Relative abundance of Veillonella spp.
The intervention showed no clear difference in relative abundance of Veillonella spp.; GRADE not reported.
1 finding from 1 review
Initiation of white spot lesions (WSL), visual-tactile assessment · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Sealant use reduced the incidence of new white spot lesions versus no sealant (very low certainty).
1 finding from 1 review
Intervention not reported
Dental caries prevalence · General population in Ethiopia (all ages, age range 6-100 years)
Caries prevalence was highest in the Tigray region at 46.59% (95% CI 24.64 to 68.54); certainty not graded.
1 finding from 1 review
Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, fibre-optic transillumination pooled sensitivity was 0.97 (95% CI -0.92 to 0.99) for occlusal caries at the caries detection level; ungraded.
4 findings from 1 review
Sensitivity 0.97 [-0.92, 0.99]
1 study
GRADE not reported
AUC 0.92
1 study
GRADE not reported
DOR 38.33 [10.15, 144.77]
1 study
GRADE not reported
Show 1 more finding
Intervention not reported
Dental caries prevalence · General population in Ethiopia (all ages, age range 6-100 years)
The pooled prevalence of dental caries in Ethiopia (2000-2020) was 40.98% (95% CI 31.62 to 50.34), with very high heterogeneity (I2=98.6%); certainty not graded.
1 finding from 1 review
Gingival inflammation-related index · Adolescents/teenagers undergoing orthodontic treatment
A single study reported lower simplified gingival index with aligners versus fixed appliances in adolescents at 1 month (MD -8.46, 95% CI -10.47 to -6.45; ungraded).
1 finding from 1 review
MD -8.46 [-10.47, -6.45]
1 study
GRADE not reported
Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo)
Under in vivo conditions, visual examination had a pooled specificity of 0.76 (95% CI 0.11, 0.99) for proximal caries detection at the dentin detection level; ungraded.
4 findings from 1 review
Show 1 more finding
Dental caries · Individuals in East Africa assessed for dental caries
Poor tooth brushing was associated with significantly higher odds of dental caries (OR 1.967, 95% CI 1.205 to 3.211); certainty not graded.
1 finding from 1 review
Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances
For compomer-based bonding agents, fluoride release did not significantly change WSL initiation (RR 0.71); subgroup not separately GRADE-rated.
1 finding from 1 review
Intervention not reported
Mean DMFT (decayed, missing, filled permanent teeth)
1 finding from 1 review
Intervention not reported
Water samples with fluoride concentration outside the acceptable range
1 finding from 1 review
Masking effect / color improvement · Patients with white spot lesions or developmental enamel defects
Two studies compared resin infiltration with microabrasion, but no pooled or comparative effect estimate was reported (ungraded).
1 finding from 1 review
no estimate extracted
2 studies
GRADE not reported
Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)
Under in vitro conditions, visual examination had a summary ROC AUC of 0.85 for proximal caries detection at the dentin detection level; ungraded.
4 findings from 1 review
Show 1 more finding
Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances
Among non-fluoride sealants, WSL initiation was significantly reduced versus no sealant (RR 0.69); subgroup not separately GRADE-rated.
1 finding from 1 review
Intervention not reported
Dental caries prevalence
1 finding from 1 review
Probing pocket depth (PPD/PD) · Adults undergoing orthodontic treatment
Aligners may reduce pocket depth compared with fixed appliances in adults at 6-12 weeks (MD -0.42 mm, 95% CI -0.71 to -0.12; very low certainty).
1 finding from 1 review