Question · asked by 1 review
Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment): Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality)
- Population
- Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
- Intervention
- Higher number of lost teeth (per one additional lost tooth)
- Comparison
- Fewer lost teeth (continuous, per-tooth increment)
- Outcome
- Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality)
Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for ACVD-related events (13 studies, I2=75%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
What each review found
Include earlier review versionsNo studies found 0 · 0%GRADE not reported 2 · 66.7%Very low 0 · 0%Low 1 · 33.3%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment) Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report, Multivariable-adjusted Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for ACVD-related events (13 studies, I2=75%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) All outcomes | HR 1.02 [1.01, 1.03] | 13 studies · 4639644 participants | Low |
Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment) Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report, Crude Each additional lost tooth was associated with a crude HR of 1.01 (95% CI 0.99 to 1.03) for ACVD-related events (1 study, I2 not applicable (single study)), not statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) All outcomes | HR 1.01 [0.99, 1.03] | 1 study · 1385 participants | GRADE not reported |
Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment) Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report, Adjusted for age/sex Each additional lost tooth was associated with a age/sex-adjusted HR of 1.01 (95% CI 1.00 to 1.03) for ACVD-related events (7 studies, I2=79%), not statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) All outcomes | HR 1.01 [1.00, 1.03] | 7 studies · 4546574 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival Data. 2021 All outcomes | Before 17 June 2020 | 140 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.