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Peripheral plus spectacle lenses · children with progressive myopia (38 studies, 6525 participants in analyses) Interventions: optical and…

Multifocal spectacle lenses · children with progressive myopia (38 studies, 6525 participants in analyses) Interventions: optical and…

Mean change in patient‐reported comfort score from baseline using CLDEQ‐8 · adults with refractive errors

Mean change in patient‐reported comfort score from baseline using OSDI, at 1 month (MD < 0 favored) · adults with refractive errors

Mean change in patient‐reported comfort score from baseline using VAS, at 1 week (MD > 0 favored) · adults with refractive errors

Proportion of participants who discontinued contact lens wear, at 1 week (RR < 1 favored) · adults with refractive errors

Corneal staining scores, at 1 week (MD < 0 favored) · adults with refractive errors

Conjunctival staining scores, at 1 month (MD < 0 favored) · adults with refractive errors

Proportion of participants with vision‐threatening adverse events (RR < 1 favored) · adults with refractive errors

Manifest keratoconus

Subclinical keratoconus

Mean change in BCVA from baseline · people with large macular hole

Mean postoperative BCVA (lower is better) · people with large macular hole

Overall closure of macular hole at end of · people with large macular hole

Speed of visual acuity improvement · people with large macular hole

Type 1 macular hole closure at end of · people with large macular hole

Postoperative retinal detachment at end of · people with large macular hole

Changes in mean participant‐reported ocular pain from baseline to 24 hours · corneal abrasion (post‐trauma or post‐surgical)

Proportion of participants with complications at longest time point Up to 1 week · corneal abrasion (post‐surgical)

Changes in mean participant‐reported ocular pain from baseline to 48 hours · corneal abrasion (post‐trauma or post‐surgical)

Changes in mean participant‐reported ocular pain from baseline to 72 hours · corneal abrasion (post‐trauma or post‐surgical)

Proportion of participants without complete resolution of epithelial defects by 24 to 72 hours · corneal abrasion (post‐trauma or post‐surgical)

Proportion of participants with complications at longest time point Up to 2 weeks · corneal abrasion (post‐trauma or post‐surgical)

Changes in mean participant‐reported ocular pain from baseline to 24 hoursVAS (scale 0 to 10) · corneal abrasion (post‐surgical)

Changes in mean participant‐reported ocular pain from baseline to 48 hours · corneal abrasion (post‐surgical)

Changes in mean participant‐reported ocular pain from baseline to 72 hours · corneal abrasion (post‐surgical)

Proportion of participants without complete resolution of epithelial defects by 24 to 72 hours · corneal abrasion (post‐surgical)

Proportion of participants with IOP control (higher number of events is better) · Participants with acute primary angle closure after initial medical treatment to lower intraocular pressure

Proportion of participants requiring further IOP‐lowering interventions (additional surgery, medications, or both) (lower number of events is better) · Participants with acute primary angle closure after initial medical treatment to lower intraocular pressure

Proportion of participants with 1 or more recurrent APAC episodes in the same eye (lower number of events is better) · Participants with acute primary angle closure after initial medical treatment to lower intraocular pressure

Mean number of IOP‐lowering medications required (lower number of medications is better) · Participants with acute primary angle closure after initial medical treatment to lower intraocular pressure

Mean IOP, measured by any method (mmHg) (lower IOP is better) · Participants with acute primary angle closure after initial medical treatment to lower intraocular pressure

Mean change in angle findings, measured by any method · Participants with acute primary angle closure after initial medical treatment to lower intraocular pressure

Adverse effects · Participants with acute primary angle closure after initial medical treatment to lower intraocular pressure

Visual acuity · children younger than two years of age with bilateral congenital cataracts

Visual axis opacification · children younger than two years of age with bilateral congenital cataracts

Amblyopia ‐ not reported · children younger than two years of age with bilateral congenital cataracts

Glaucoma at 5 years · children younger than two years of age with bilateral congenital cataracts

Retinal detachment ‐ not reported · children younger than two years of age with bilateral congenital cataracts

Reoperation rate ‐ not reported · children younger than two years of age with bilateral congenital cataracts

Adverse events · children younger than two years of age with bilateral congenital cataracts

Failure to control IOP (as defined by study investigators) · people with open‐angle glaucoma

Failure to stabilise optic neuropathy progression (as defined by study investigators) · people with open‐angle glaucoma

Quality of life · people with open‐angle glaucoma

Adverse effectsPAS formation · people with open‐angle glaucoma

Adverse effects: IOP spikes · people with open‐angle glaucoma

Failure to stabilise visual field progression (as defined by study investigators) · people with open‐angle glaucoma

Failure to stabilise optic neuropathy progression (as defined by study investigators) · people with open‐angle glaucoma

Quality of life measures · people with open‐angle glaucoma

Adverse effects:PAS formation · people with open‐angle glaucoma