Cochrane · systematic review · CD015091
Topical ophthalmic anesthetics for corneal abrasions
Sulewski, M, Leslie, L, Liu, S-H, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
8
No studies
2
Included studies
NR
No studies 2 · 20%Ungraded 0 · 0%Very low 8 · 80%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Topical ophthalmic anesthetic compared with placebo or NSAID
Population: corneal abrasion (post‐trauma or post‐surgical)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Changes in mean participant‐reported ocular pain from baseline to 24 hours Topical ophthalmic anesthetic vs placebo or NSAID | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision |
Changes in mean participant‐reported ocular pain from baseline to 48 hours Topical ophthalmic anesthetic vs placebo or NSAID | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, indirectness |
Changes in mean participant‐reported ocular pain from baseline to 72 hours Topical ophthalmic anesthetic vs placebo or NSAID | no estimate extracted | 1 study · 44 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Proportion of participants without complete resolution of epithelial defects by 24 to 72 hours Topical ophthalmic anesthetic vs placebo or NSAID | no estimate extracted | NR | Very low Downgraded: imprecision, inconsistency, indirectness |
Proportion of participants with complications at longest time point Up to 2 weeks Topical ophthalmic anesthetic vs placebo or NSAID | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, indirectness |
Topical ophthalmic anesthetic plus NSAID compared with placebo
Population: corneal abrasion (post‐surgical)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Changes in mean participant‐reported ocular pain from baseline to 24 hoursVAS (scale 0 to 10) Topical ophthalmic anesthetic plus NSAID vs placebo | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision |
Changes in mean participant‐reported ocular pain from baseline to 48 hours Topical ophthalmic anesthetic plus NSAID vs placebo | no estimate extracted | NR | No studies |
Changes in mean participant‐reported ocular pain from baseline to 72 hours Topical ophthalmic anesthetic plus NSAID vs placebo | no estimate extracted | NR | No studies |
Proportion of participants without complete resolution of epithelial defects by 24 to 72 hours Topical ophthalmic anesthetic plus NSAID vs placebo | RR 0.33 [0.04, 2.85] | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision |
Proportion of participants with complications at longest time point Up to 1 week Topical ophthalmic anesthetic plus NSAID vs placebo | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision |