Search review questions

Quality of life · People with established (manifest) MRONJ · 6 months

Early childhood caries (ECC) - association with genetically predicted expression of LINC02905 (C8orf49) (chr8p23.1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5… · Cross-sectional (ECC ascertained at the last dental exam before age 6), Population/community child cohorts: rural Appalachia (West Virginia, Pennsylvania) and Iowa (USA) and South West England; European / European non-Hispanic ancestry only, LINC02905 (C8orf49) (chr8p23.1); 9 (3) tissues; significant (Bonferroni p < 3.09x10-6) ; flagged possible false positive

Oral health-related quality of life · Children with dental caries · Network estimate

Retention of sealant (complete or partial retention) · 'Healthy' children with caries-free second primary molars, aged 3-5 years (schools and kindergartens, India and China) · 24 months

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · Burkina Faso (Africa), Country: Burkina Faso

Restoration failure · Children with carious primary teeth · 1.5 years, Not reported, Class II

Caries experience at the tooth level (dmft) · Children (mean age newborn to ~5.2 years) and their parents/carers · Primary care and community settings; interventions delivered by non-dental health workers (multiple countries: Australia, Brazil, Canada, India, UK, USA, etc.)

Adverse events · People aged 12 years and over with painful TMD lasting 3 months or longer

Dental caries measured by net increment in DMFT scores · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs) · Post-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer), Primary schools in low- and middle-income countries (Southeast Asia, Africa, the Americas, Europe, eastern Mediterranean), Age 9-12 years

Access to/visited dental services prevalence · Children in low- and middle-income countries (both with and without dental caries) · Low- and middle-income countries (Brazil, Nigeria, Cambodia, Tanzania, Mexico, Ethiopia)

Caries prevalence · 12-year-old children (permanent dentition) in Africa · Africa (cross-sectional surveys), Data collection period: >2015

Caries arrest rate (absolute proportion of lesions arrested) · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars · Follow-up >=12 months, Pediatric dental care in hospital, community/school and outpatient settings (Saudi Arabia, China, India, Brazil, Spain)

Restoration failure · Children (3-10 years) with dentine caries in primary molars · 1-5 years

Restoration failure · Children with carious primary teeth · 1 year, School setting, ART; Class I

Secondary caries · Patients with permanent dentition in need of restorations · 18 months to 2 years, University, private practice, primary school, and multicenter settings, All types of cavities

Caries prevalence · European adolescents aged 12–19 years · Europe (community, subnational and national dental surveys), Examination year: < 2010

Early childhood caries (ECC) - association at lead SNP rs76823412 (8:134690570; nearest gene(s) ST3GAL1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5… · Cross-sectional (ECC ascertained at the last dental exam before age 6), Population/community child cohorts: rural Appalachia (West Virginia, Pennsylvania) and Iowa (USA) and South West England; European / European non-Hispanic ancestry only, rs76823412 (8:134690570); effect/non-effect allele T/C; MAF 0.47; direction across 5 cohorts +++++

Dental attendance · School children, primary and secondary schools in the UK · 3 to 4 months

Contribution of dental care products to total daily fluoride intake (TDFI), by tap-water fluoride level · Children using fluoride-containing dental care products (majority of included studies) · Habitual daily intake, Multiple countries (28 studies; ~43% conducted in Brazil); community/general-population settings, Extreme-fluoridated tap water (>1.5 mg/L)

Caries prevalence · European adolescents aged 19 years · Europe, Exact age

Specificity for detecting enamel caries · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies) · General dental practice; in vitro (extracted teeth) and in vivo (clinical) studies, Analysis 2: network meta-analysis (all studies evaluating >=2 index tests)

Color change · Patients with post-orthodontic white spot lesions and permanent dentition · 6 months, Permanent teeth

Caries (DMFT/DMFS) in mixed/permanent dentition · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of… · Cohort studies (Netherlands, USA)

Caries experience in the primary dentition (dmft/dmfs/dfs/deft/ds; pooled as standardized mean difference) · Children in the primary dentition with non-syndromic cleft lip and/or palate (CL/P) and comparable children without CL/P · Children with CL/P and comparable non-CL/P children across 12 countries (India, Brazil, China, Sweden, UK, USA, Germany, Greece, Ireland, Netherlands, Jordan, Thailand); studies published 1989-2021, Overall (all dentition groups)

C-reactive protein (CRP) · People with periodontitis and metabolic syndrome (no CVD; primary prevention) · 12 months

Difference in summary specificity (NMA, Analysis 2) · Electrical conductance vs Visual

Difference in summary sensitivity (NMA, Analysis 2) · Electrical conductance vs Transillumination

Caries prevalence · 12-year-old children (permanent dentition) in Africa · Tanzania (Africa), Country: Tanzania

Caries arrest · Children with dentine carious lesions (ICDAS 4-5) in primary teeth · 24 months, Biannual vs annual application

Immediate bond strength (MPa) · Dental adhesives bonded to caries-affected dentin (in vitro) · Immediate bond strength, In vitro (laboratory bond-strength testing), Caries-affected dentin (without rinsing step)

Pain intensity at treatment completion · People aged 12 years and over with painful TMD lasting 3 months or longer · Treatment completion

Contribution of dental care products to total fluoride exposure · Pregnant and lactating women

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars) · Follow-up: median 7 days

Pain disability at follow-up · People aged 12 years and over with painful TMD lasting 3 months or longer · Follow-up

Dental caries measured by net increment in DMFS scores · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs) · Post-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer), Primary schools in low- and middle-income countries (Southeast Asia, Africa, the Americas, Europe, eastern Mediterranean)

Caries prevalence · 12-year-old children (permanent dentition) in Africa · Algeria (Africa), Country: Algeria

Contribution of dental care products to total daily fluoride intake (TDFI), by tap-water fluoride level · Children using fluoride-containing dental care products (majority of included studies) · Habitual daily intake, Multiple countries (28 studies; ~43% conducted in Brazil); community/general-population settings, Poor-fluoridated tap water (<0.3 mg/L)

MRONJ (incidence proportion) · People with cancer treated with intravenous bisphosphonates undergoing dental extractions (at risk of MRONJ) · 24 to 60 months

Postobturation pain at 1 week · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without… · 1 week postobturation

Middle SES prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries · Low- and middle-income countries (Brazil, Nigeria, Cambodia, Tanzania, Mexico, Ethiopia), Middle SES

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them · assistant level

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars) · Follow-up: median 7 days

Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) · Hospitals and AIDS outpatient centres in India, Brazil, and several Asian countries

Crown retention · Children with primary (deciduous) teeth requiring full-coverage crown restoration · 12 months, Pediatric dental clinical settings

Tooth loss · Adults with a clinical diagnosis of (chronic) periodontitis (1999 classification); studies of aggressive…

High SES prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries · Low- and middle-income countries (Brazil, Nigeria, Cambodia, Tanzania, Mexico, Ethiopia), High SES

Food preference · Children and adolescents aged 0-19 years · Crossover designs with binary outcomes

Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of… · Cohort studies (Sweden, USA)

Linear gingival erythema (WHO clinical stage 2) · Children and adolescents (<18 years) · Cross-sectional (case-control; single time point), HIV pediatric/ART clinics, AIDS centers, and hospitals in Brazil, India, Saudi Arabia, and West Africa (Cote d'Ivoire, Mali, Senegal)

Caries prevalence · 12-year-old children (permanent dentition) in Africa · Zambia (Africa), Country: Zambia