Search review questions

Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of… · 8-year follow-up, Cohort study, China (Li & Wang 2002), Upper incisors

Clinical and radiographic success rate (>=6 months) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure · >=6 months, Clinical (endodontic/dental), Pulp capping material: MTA vs calcium hydroxide

Diet-related noncommunicable diseases · Children and adolescents aged 0-19 years · Predominantly high-income countries

Contribution of dental care products to total daily fluoride intake (TDFI) · Humans using fluoride-containing dental care products; 28 included studies, mostly young children, only two studies in… · Habitual daily intake, Multiple countries (28 studies; ~43% conducted in Brazil); community/general-population settings

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them · assistant level

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them · operator level; aerobic cultures

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them · CPC vs water; operator level

Development of >=1 new carious lesion (caries incidence) · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department,… · 24 months

Caries experience - mean dmft (descriptive), primary dentition · CL/P vs no CL/P; Table 4 (15 groups/13 studies)

Gingivitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) · Hospitals and AIDS outpatient centres in India, Brazil, and several Asian countries

MRONJ after tooth extraction (incidence proportion) · People on antiresorptive therapy for cancer or osteoporosis undergoing dental extractions (at risk of MRONJ) · 6 months

Plaque quantity (plaque index or plaque weight) · Adults and children (predominantly adults; one study in children), with natural dentition · End of study (last reported time point; study durations 4 days to 2 years), Community, residential care homes, and schools; predominantly adults, Sensitivity analysis (pre-post correlation set to 0.95 for the SFG group)

Change in clinical attachment level (CAL) · Adults with a clinical diagnosis of (chronic) periodontitis (1999 classification); studies of aggressive… · 6 to 8 months (SoF); similar at 3 to 4 months

Oral health-related quality of life · Children with dental caries · Network estimate

Dental caries (association with low SES) · Children (deciduous and/or permanent dentition) in low- and middle-income countries · Low- and middle-income countries (Brazil, Nigeria, Cambodia, Tanzania, Mexico, Ethiopia), Low SES

Mean number of arrested caries surfaces · 38% SDF vs comparators (NaF/no treatment)

Contribution of dental care products to total daily fluoride intake (TDFI), by tap-water fluoride level · Children using fluoride-containing dental care products (majority of included studies) · Habitual daily intake, Multiple countries (28 studies; ~43% conducted in Brazil); community/general-population settings, Medium-fluoridated tap water (0.52-0.77 mg/L)

Restoration failure · Children with carious primary teeth · 1 year, University, Class II

Immediate bond strength (MPa) · Dental adhesives bonded to caries-affected dentin (in vitro) · Immediate bond strength, In vitro (laboratory bond-strength testing), Caries-affected dentin (with rinsing step)

Pain intensity at follow-up (6-12 months) · People aged 12 years and over with painful TMD lasting 3 months or longer · Follow-up (6-12 months)

Serum high-sensitivity C-reactive protein (hs-CRP) · People with cardiovascular disease and chronic periodontitis · 12 months

Dental caries (early childhood caries) · Healthy children under 6 years in South Africa · South Africa

Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of… · At least 24 months follow-up (3-12 years), School/community-based cohort studies (USA, China, Norway)

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them · assistant level

Treatment failure (annual failure rate) · Children with deep dentine caries in primary molars restored with composite resin (indirect pulp treatment; pulpotomy… · 36 months, University, Brazil (Liberman et al. 2020 / Franzon et al. 2015), Selective caries removal (SCR) arm

Cost implications of antibiotic provision · Adults or children at increased risk of bacterial endocarditis (pre-existing cardiac condition) undergoing an invasive…

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · Eritrea (Africa), Country: Eritrea

Psychological distress at treatment completion · People aged 12 years and over with painful TMD lasting 3 months or longer · Treatment completion

Dental caries measured by DMFS scores · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs) · Post-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer), Primary schools in low- and middle-income countries (Southeast Asia, Africa, the Americas, Europe, eastern Mediterranean), >3 intervention activities

Pain at 1 month · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without… · 1 month

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars) · Follow-up: median 7 days

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars) · Follow-up: median 7 days

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them · operator level

Cost · Dental patients undergoing aerosol-generating procedures (AGPs)

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · South Africa (Africa), Country: South Africa

HIV-related oral lesions · Children living with HIV receiving ART · CD4+ T-cell count below 250 cells/mm3

Mean caries increment (dmft) · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric… · 12 months

Overweight/obesity risk · Healthy children aged 6–24 months in Western industrialized countries · 24 months, Outpatient, BLISS RCTs

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · Africa (cross-sectional surveys), Data collection period: 2005-2009

Food purchasing · Vote counting by direction of effect; clear association of public health harm

Restoration failure · Children with carious primary teeth · 1 year, University, Class II

Change in bleeding on probing (BOP) · Adults with a clinical diagnosis of (chronic) periodontitis (1999 classification); studies of aggressive… · 6 to 8 months (SoF); similar at 3 to 4 months

Difference in summary specificity (NMA, Analysis 2) · Transillumination vs Visual

Chronic herpes simplex infection prevalence · Children and adolescents (<18 years) living with HIV (CLWH) · Hospitals and AIDS outpatient centres in India, Brazil, and several Asian countries

Treatment failure (annual failure rate) · Children with previously unrestored, vital carious lesions in primary teeth (no pulp therapy); aged 1.5-11 years · 12 months (El-Housseiny 2019), University (Saudi Arabia)

Caries arrest · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars · Follow-up up to 12 months (single application), Pediatric dental care in hospital, community/school and outpatient settings (Saudi Arabia, China, India, Brazil, Spain), SDF application frequency: single (one-time) application

Mineral loss (transversal microradiography) · Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by… · Median 21 days (range 14-28 days), In situ (intraoral appliance); net-remineralizing model, Net-remineralizing conditions

Dental caries detection accuracy · Dental images of human beings · India, Geetha et al., 2020; backpropagation

Caries incidence in first permanent molars · Schoolchildren aged 6-12 years with sound occlusal surfaces of the first permanent molars · 24 months, School-based caries prevention; schoolchildren (included trials aged 6-9 years)

Contribution of dental care products to total daily fluoride intake (TDFI), by tap-water fluoride level · Adults using fluoride-containing dental care products (two included studies [28,47]; aged 20-35) · Habitual daily intake, Multiple countries (28 studies; ~43% conducted in Brazil); community/general-population settings, Low-fluoridated tap water (0.3-0.51 mg/L)