Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,747 questions · 3,943 findings · 594 reviews

No studies found 784 · 19.9%GRADE not reported 530 · 13.4%Very low 1,040 · 26.4%Low 981 · 24.9%Moderate 444 · 11.3%High 164 · 4.2%

Early enteral nutrition vs delayed enteral nutrition

Feed intolerance or gastrointestinal complications (as defined by the authors) · critically ill adult patients

It is very uncertain whether early enteral nutrition changes feed intolerance or gastrointestinal complications (as defined by… compared with delayed enteral nutrition (very low certainty).

1 finding from 1 review

Natriuretic peptide‐guided treatment vs usual care

Ventricular dysfunction (as defined by trialists) · patients without heart failure

Natriuretic peptide‐guided treatment leads to lower ventricular dysfunction (as defined by trialists) compared with standard care (high certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Ventricular arrhythmias (within 30 days) · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

It is very uncertain whether perioperative beta‐blockers changes ventricular arrhythmias (within 30 days) compared with placebo or standard care (very low certainty).

1 finding from 1 review