Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

120 questions · 120 findings · 25 reviews · Anaesthesia

No studies found 17 · 14.2%GRADE not reported 6 · 5%Very low 23 · 19.2%Low 42 · 35%Moderate 29 · 24.2%High 3 · 2.5%

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS –lidocaine vs bupivacaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine probably leads to lower presence of any TNS –lidocaine vs bupivacaine compared with other local anaesthetic (moderate certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs 2‐chloroprocaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine showed no clear difference in presence of any TNS – lidocaine vs 2‐chloroprocaine compared with other local anaesthetic (low certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs levobupivacaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine may leads to lower presence of any TNS – lidocaine vs levobupivacaine compared with other local anaesthetic (low certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs mepivacaine · adults undergoing surgery

It is very uncertain whether risk of transient neurological symptoms with spinal lidocaine changes presence of any TNS – lidocaine vs mepivacaine compared with other local anaesthetic (very low certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs prilocaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine probably leads to lower presence of any TNS – lidocaine vs prilocaine compared with other local anaesthetic (moderate certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs procaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine probably leads to lower presence of any TNS – lidocaine vs procaine compared with other local anaesthetic (moderate certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs ropivacaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine may leads to lower presence of any TNS – lidocaine vs ropivacaine compared with other local anaesthetic (low certainty).

1 finding from 1 review

Buffered vs non‐buffered crystalloid intravenous fluid

Mortality (in‐hospital death and 30‐day mortality) · adults receiving intravenous fluids whilst undergoing any form of surgery

Buffered showed no clear difference in mortality (in‐hospital death and 30‐day mortality) compared with non‐buffered crystalloid intravenous fluid (low certainty).

1 finding from 1 review

Buffered vs non‐buffered crystalloid intravenous fluid

Organ system failure ‐ renal insufficiency requiring support · adults receiving intravenous fluids whilst undergoing any form of surgery

Buffered showed no clear difference in organ system failure ‐ renal insufficiency requiring support compared with non‐buffered crystalloid intravenous fluid (low certainty).

1 finding from 1 review