Cochrane · systematic review · CD003006
Transient neurological symptoms (TNS) following spinal anaesthesia with lidocaine versus other local anaesthetics in adult surgical patients: a network meta‐analysis
Forget, P, Borovac, JA, Thackeray, EM, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
AnaesthesiaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 3 · 42.9%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Risk of transient neurological symptoms with spinal lidocaine compared to other local anaesthetic in adults undergoing surgery
Population: adult undergoing surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Presence of any TNS –lidocaine vs bupivacaine Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic | RR 0.16 [0.09, 0.28] | 12 studies · 1220 participants | Moderate Downgraded: risk of bias |
Presence of any TNS – lidocaine vs 2‐chloroprocaine Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic | RR 0.09 [0.01, 1.51] | 2 studies · 94 participants | Low Downgraded: risk of bias, publication bias |
Presence of any TNS – lidocaine vs levobupivacaine Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic | RR 0.13 [0.02, 0.69] | 2 studies · 120 participants | Low Downgraded: imprecision, inconsistency |
Presence of any TNS – lidocaine vs mepivacaine Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic | RR 1.01 [0.18, 5.82] | 4 studies · 274 participants | Very low Downgraded: imprecision, inconsistency, publication bias |
Presence of any TNS – lidocaine vs prilocaine Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic | RR 0.18 [0.07, 0.49] | 4 studies · 429 participants | Moderate Downgraded: risk of bias |
Presence of any TNS – lidocaine vs procaine Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic | RR 0.14 [0.04, 0.52] | 2 studies · 130 participants | Moderate Downgraded: inconsistency |
Presence of any TNS – lidocaine vs ropivacaine Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic | RR 0.1 [0.01, 0.78] | 2 studies · 90 participants | Low Downgraded: risk of bias, imprecision |