Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,087 questions · 2,360 findings · 390 reviews

No studies found 224 · 9.5%GRADE not reported 603 · 25.6%Very low 555 · 23.5%Low 548 · 23.2%Moderate 312 · 13.2%High 118 · 5%

ANY INTERMITTENT DRUG TECHNIQUE vs MAINTENANCE THERAPY

Leaving the study early/ loss to · patients with schizophrenia

It is very uncertain whether INTERMITTENT (DRUG HOLIDAY) changes leaving the study early/ loss to compared with MAINTENANCE THERAPY (very low certainty).

2 findings from 1 review

DANCE THERAPY vs usual care

Clinical global response‐leaving the study early (short term) · patients with schizophrenia

DANCE THERAPY showed no clear difference in clinical global response‐leaving the study early (short term) compared with STANDARD CARE (moderate certainty).

1 finding from 1 review

DANCE THERAPY vs usual care

Clinical global response‐leaving the study early (long term) · patients with schizophrenia

DANCE THERAPY showed no clear difference in clinical global response‐leaving the study early (long term) compared with STANDARD CARE (low certainty).

1 finding from 1 review

Acupuncture vs placebo or sham acupuncture

Adverse events Adverse events includes withdrawal and drop‐outs that could be clearly identified as due to an adverse event · patients with fibromyalgia

Acupuncture showed no clear difference in adverse events Adverse events includes withdrawal and drop‐outs that… compared with placebo or sham acupuncture (moderate certainty).

1 finding from 1 review

SWITCHING ANTIPSYCHOTIC: TO OLANZAPINE vs MAINTENANCE RISPERIDONE/FGA

Leaving the study early · patients with sexual dysfunction due to antipsychotic drug therapy

It is very uncertain whether SWITCHING ANTIPSYCHOTIC: TO OLANZAPINE changes leaving the study early compared with MAINTENANCE RISPERIDONE/FGA (very low certainty).

1 finding from 1 review

Sildenafil vs placebo

Leaving the study early · patients with sexual dysfunction due to antipsychotic drug therapy

It is very uncertain whether ADJUNCTIVE TREATMENT ‐ SPECIFIC: SILDENAFIL changes leaving the study early compared with PLACEBO (very low certainty).

1 finding from 1 review

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

Unacceptability of treatment (drop-outs / leaving study early) · patients with schizophrenia

It is very uncertain whether ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS changes leaving the study early due to any reason (overall acceptability of… compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

Adverse effects (drop‐outs due to adverse effects4) · patients with schizophrenia

It is very uncertain whether ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS changes leaving the study early due to adverse effects (overall tolerability… compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

BENZODIAZEPINES AS SOLE TREATMENT vs placebo

Unacceptability of treatment (drop-outs / leaving study early) · patients with schizophrenia

It is very uncertain whether BENZODIAZEPINES AS SOLE TREATMENT changes leaving the study early due to any reason (overall acceptability of… compared with PLACEBO (very low certainty).

1 finding from 1 review