Cochrane · systematic review · CD007815
Quetiapine versus typical antipsychotic medications for schizophrenia
Suttajit, S, Srisurapanont, M, Xia, J, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 0 · 0%Moderate 6 · 85.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Quetiapine compared to Typical antipsychotics for schizophrenia
Population: patients with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global state No clinical significant response as defined by the individual studies Quetiapine vs Typical antipsychotics | RR 0.96 [0.75, 1.23] | 16 studies · 1607 participants | Moderate Downgraded: risk of bias |
Leaving the study early due to any reason Quetiapine vs Typical antipsychotics | RR 0.91 [0.81, 1.01] | 23 studies · 3576 participants | Moderate Downgraded: risk of bias |
Positive symptoms PANSS positive subscore Quetiapine vs Typical antipsychotics | no estimate extracted | 22 studies · 1934 participants | Moderate Downgraded: risk of bias |
Negative symptoms PANSS negative subscore Quetiapine vs Typical antipsychotics | no estimate extracted | 22 studies · 1934 participants | Moderate Downgraded: risk of bias |
Cognitive function Average endpoint scores as defined by the original studies Quetiapine vs Typical antipsychotics | no estimate extracted | 3 studies · 142 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Extrapyramidal effects Quetiapine vs Typical antipsychotics | RR 0.17 [0.09, 0.32] | 8 studies · 1095 participants | Moderate Downgraded: risk of bias |
Prolactin level Average level in ng/mL Quetiapine vs Typical antipsychotics | no estimate extracted | 4 studies · 1034 participants | Moderate Downgraded: risk of bias |