Cochrane · systematic review · CD009582
Atypical antipsychotics for psychosis in adolescents
Kumar, A, Datta, SS, Wright, SD, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
19
current version
GRADE rated
19
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 5.3%Low 2 · 10.5%Moderate 7 · 36.8%High 9 · 47.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Atypical antipsychotics compared with placebo (only short term)
Population: individuals with psychosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight gain Atypical antipsychotics vs placebo (only short term) | no estimate extracted | 1 study · 107 participants | Moderate Downgraded: imprecision |
Weight gain ≥7% of baseline Atypical antipsychotics vs placebo (only short term) | no estimate extracted | 1 study · 106 participants | High |
High prolactin at any time during treatment Atypical antipsychotics vs placebo (only short term) | no estimate extracted | 1 study · 107 participants | High |
Change in corrected QT Atypical antipsychotics vs placebo (only short term) | no estimate extracted | 1 study · 107 participants | High |
Atypical compared with typical antipsychotics (only short term)
Population: individuals with psychosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Worse or no improvement Atypical vs typical antipsychotics (only short term) | no estimate extracted | 1 study · 21 participants | Low Downgraded: imprecision |
Anticholinergic adverse effects Atypical vs typical antipsychotics (only short term) | no estimate extracted | 1 study · 40 participants | Moderate Downgraded: risk of bias |
Drop in the absolute neutrophil count below 1500 per mm3 Atypical vs typical antipsychotics (only short term) | no estimate extracted | 1 study · 21 participants | Very low Downgraded: imprecision |
Leaving the study early because of adverse effects Atypical vs typical antipsychotics (only short term) | no estimate extracted | 1 study · 21 participants | Moderate Downgraded: imprecision |
Atypical vs atypical antipsychotics (only short term)
Population: individuals with psychosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
No improvement (risperidone vs olanzapine) Atypical vs atypical antipsychotics (only short term) | no estimate extracted | 2 studies · 111 participants | Moderate |
No improvement (clozapine vs olanzapine) Atypical vs atypical antipsychotics (only short term) | no estimate extracted | 1 study · 39 participants | High |
Use of other antipsychotics Atypical vs atypical antipsychotics (only short term) | no estimate extracted | 1 study · 28 participants | Moderate Downgraded: imprecision |
Drug‐induced diabetes (clozapine vs olanzapine) Atypical vs atypical antipsychotics (only short term) | no estimate extracted | 1 study · 28 participants | Moderate Downgraded: imprecision |
Elevated prolactin (risperidone vs quetiapine) Atypical vs atypical antipsychotics (only short term) | no estimate extracted | 1 study · 22 participants | Moderate Downgraded: risk of bias |
Weight gain in kg (risperidone vs olanzapine) Atypical vs atypical antipsychotics (only short term) | no estimate extracted | 1 study · 76 participants | High |
Leaving the study early because of weight gain (risperidone vs olanzapine) Atypical vs atypical antipsychotics (only short term) | no estimate extracted | 1 study · 19 participants | Low Downgraded: imprecision |
Atypical (standard‐dose) vs atypical (low‐dose) antipsychotics (only short term)
Population: individuals with psychosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
No response Atypical (standard‐dose) vs atypical (low‐dose) antipsychotics (only short term) | no estimate extracted | 1 study · 255 participants | High |
Symptomatic hyperprolactinaemia Atypical (standard‐dose) vs atypical (low‐dose) antipsychotics (only short term) | no estimate extracted | 1 study · 257 participants | High |
Use of antiparkinsonian medications Atypical (standard‐dose) vs atypical (low‐dose) antipsychotics (only short term) | no estimate extracted | 1 study · 257 participants | High |
Weight gain (standard‐dose vs low‐dose risperidone) Atypical (standard‐dose) vs atypical (low‐dose) antipsychotics (only short term) | no estimate extracted | 1 study · 257 participants | High |